PULMONARY ARTERIAL HYPERTENSION
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| Remodulin (SC OR IV infusion) Tyvaso (inhaler) Orenitram (ER tablet) | Treprostinil | MOA:- same as Flolan/veletri
CI:- oral tab -severe hepatic impairment
side effects:- hypotension, headache, dizziness, N/V/D , jaw pain, infusion site reaction (IV/SC infusion), cough and mouth throat irritation (inhaler)
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| ventavis (inhaler) | Iioprost | MOA - same as Floan/veletri
side effects:- hypotension, headache, dizziness, N/V/D , jaw pain,
cough and mouth throat irritation
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| Tracleer | Bosentan | MOA:- works by antagonizing endothelin receptor.CI- pregnancy, hepatotoxicity, use with cyclosporine and glyburide
side effects:- Hypersensitivity reactions,headache, upper respiratory infections, hypotension, flushing
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| Uptravi (tablet) | Selexipag | MOA:- prostacyclin analogues (potent vasodilator).Side effects:- hypotension, headache, dizziness, N/V/D , jaw pain,
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| Letairis | Ambrisentan | MOA:- works by antagonizing endothelin receptor.CI- pregnancy, idiopathic pulmonary fibrosis. Side effects:-headache, upper respiratory infections, hypotension, flushing
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| Opsumit | Macitentan | MOA:-works by antagonizing endothelin receptor. CI:- pregnancy. Side effects:- headache, upper respiratory infections, hypotension, flushing
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| Revatio | Sildenafil | MOA- works by inhibiting Phosphodiesterase-5 (PDE-5). CI:- use with nitrates or riociguat or HIV protease inhibitors. Side effects:- Headache, flushing, dyspepsia, extremity or back pain, N/D, epistaxis
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| Adcirca | Tadalafil | MOA:- works by inhibiting Phosphodiesterase-5 (PDE-5).CI:- use with nitrates or riociguat or HIV protease inhibitors. Side effects:- Headache, flushing, dyspepsia, extremity or back pain, N/D, epistaxis
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| Adempas | Riociguat | MOA:- works by stimulating soluble guanylate cyclase which is receptor for endogenous nitric oxide. CI:- pregnancy, use of PDE-5 inhibitors or nitrates. Side effect:- headache, hypotension, bleeding, pulmonary edema, dyspepsia, dizziness, N/V/D.
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| Flolan, Veletri | Epoprostenol | MOA- works as prostacyclin analogues (potent vasodilator) and also by inhibiting platelet aggregation.CI - heart failure with low left ventricular ejection fraction
SIDE EFFECTS - hypotension, headache, dizziness, N/V/D , jaw pain
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Popular Pharmacology sets