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specialty pharmacy

PULMONARY ARTERIAL HYPERTENSION

BRANDGENERICMOA, CI, SIDE EFFECTS
Remodulin (SC OR IV infusion) Tyvaso (inhaler) Orenitram (ER tablet) Treprostinil MOA:- same as Flolan/veletri CI:- oral tab -severe hepatic impairment side effects:- hypotension, headache, dizziness, N/V/D , jaw pain, infusion site reaction (IV/SC infusion), cough and mouth throat irritation (inhaler)
ventavis (inhaler) Iioprost MOA - same as Floan/veletri side effects:- hypotension, headache, dizziness, N/V/D , jaw pain, cough and mouth throat irritation
Tracleer Bosentan MOA:- works by antagonizing endothelin receptor.CI- pregnancy, hepatotoxicity, use with cyclosporine and glyburide side effects:- Hypersensitivity reactions,headache, upper respiratory infections, hypotension, flushing
Uptravi (tablet) Selexipag MOA:- prostacyclin analogues (potent vasodilator).Side effects:- hypotension, headache, dizziness, N/V/D , jaw pain,
Letairis Ambrisentan MOA:- works by antagonizing endothelin receptor.CI- pregnancy, idiopathic pulmonary fibrosis. Side effects:-headache, upper respiratory infections, hypotension, flushing
Opsumit Macitentan MOA:-works by antagonizing endothelin receptor. CI:- pregnancy. Side effects:- headache, upper respiratory infections, hypotension, flushing
Revatio Sildenafil MOA- works by inhibiting Phosphodiesterase-5 (PDE-5). CI:- use with nitrates or riociguat or HIV protease inhibitors. Side effects:- Headache, flushing, dyspepsia, extremity or back pain, N/D, epistaxis
Adcirca Tadalafil MOA:- works by inhibiting Phosphodiesterase-5 (PDE-5).CI:- use with nitrates or riociguat or HIV protease inhibitors. Side effects:- Headache, flushing, dyspepsia, extremity or back pain, N/D, epistaxis
Adempas Riociguat MOA:- works by stimulating soluble guanylate cyclase which is receptor for endogenous nitric oxide. CI:- pregnancy, use of PDE-5 inhibitors or nitrates. Side effect:- headache, hypotension, bleeding, pulmonary edema, dyspepsia, dizziness, N/V/D.
Flolan, Veletri Epoprostenol MOA- works as prostacyclin analogues (potent vasodilator) and also by inhibiting platelet aggregation.CI - heart failure with low left ventricular ejection fraction SIDE EFFECTS - hypotension, headache, dizziness, N/V/D , jaw pain
Created by: Briovastudent
 

 



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