Electrolytes & Acid-Base Balances
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FLUID | water that contains dissolved or suspended substances such as glucose, mineral salts, & proteins
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BODY FLUIDS ARE DISTRIBUTED IN 2 MAJOR COMPONENTS | Intracellular fluid (ICF) - inside cells 2/3 body water
Extracellular fluid (ECF) - outside cells 1/3 body water
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INTRACELLULAR | inside cells
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EXTRACELLULAR | out cells
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INTRAVASCULAR | within blood vessels
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INTERSTITIAL | within tissues
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TRANSCELLULAR | minor
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ELECTROLYTES | mineral salts, separates into ions when dissolved in water; measured in milliequivalents (mEq)
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IONS | charged particles
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CATIONS | + positively charged ions
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ANIONS | - negatively charged ions
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NA | Sodium 135 - 145 mEq/L
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K | Potassium 3.5 - 5 mEq/L
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Ca | Calcium 8.4 - 10.5 mg/dL
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Mg | Magnesium 1.5 - 2.5 mEq/L
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ACTIVE TRANSPORT | energy-requiring movement of electrolytes or other substances across cell membranes against a concentration gradient --> low concentration to high concentration --> requires ATP
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DIFFUSION | passive movement of electrolytes or other particles from an area of high concentration to one of low concentration
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OSMOSIS | movement of water across a semipermeable membrane from a compartment of low particle concentration to high particle conentration
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OSMOTIC PRESSURE | inward-pulling force of a particle in any fluid compartment to more concentrated side
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HYPERTONIC | pull fluid out of the cells by osmosis; causing them to shrink
3% sodium chloride
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ISOTONIC SOLUTION | same osmolality as normal blood; no shift in or out of cells
0.9% sodium chloride
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HYPOTONIC SOLUTION | less concentrated than normal blood; causing then to swell
5% in water/dextrose (simple sugar)
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FILTRATION | net effect of several forces that tend to move fluid across a membrane
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HYDROSTATIC PRESSURE | the force of a fluid pressing outward against the walls of its container
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COLLOID OSMOSTIC PRESSURE | an inward pulling force caused by the presence of protein molecules
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OSMORECEPTORS | continued monitor plasma osmolality; when osmolality increases, the hypothalamus stimulates thirst
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INSENSIBLE WATER LOSS | fluid loss in the lungs & skin
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ADH | regulates osmolality of body fluids by influencing how much water is excreted in urine (prevents body to save water)
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ALDOSTERONE | regulates ECV by influencing how much sodium & water are excreted in urine (water retention)
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ANGIOTENSIN | polypeptide occurring in the blood, causing vasoconstriction, increased blood pressure & the release of aldosterone from the adrenal cortex
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RENIN | produces A1 which converts to AZ & causes vasocontriction
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ATRIAL NATRIURETIC PEPTIDE (ANP) | a hormone that opposes the action of aldosterone & promotes vasodilation
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CHLORIDE | 95 - 105 mEq/L
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BICARBONATE | normal arterial 22 - 26 mEq/L
normal venous 24 - 30 mEq/L
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PHOSPHATE | 2.7 - 4.5 mg/dL
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BUFFERS | pairs of chemicals that work together to maintain normal pH of body fluids
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THE BODY HAS 2 ACID EXCRETION MECHANISMS: | 1. lungs (excrete carbonic acid ) CO2
2. kidneys (excrete metabolic acid)
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CONCENTRATION | osmolality
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ECV EXCESS | to much isotonic fluid in the extracellular tissue
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HYPOVOLEMIA | the decreased vascular volume in ECV deficit (eg: hemorrhage)
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HYPERNATREMIA | abnormally high NA (salt) concentration in ECF caused by loss of relatively more water than salt or gain of relatively more salt than water
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HYPOKALEMIA | abnormally high blood K (potassium) concentration
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HYPERKALEMIA | abnormally high CA concentration in the blood
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FLUID OUT REGULATION; FLUID IS LOST FROM: | kidneys
skin
lung
GI tract
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HYPONATREMIA | abnormally low Na (salt) in the ECF, occurs from gaining relatively more water than salt or losing more salt than water
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HYPERMAGNESEMIA | abnormally high Mg (magnesium)
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HYPOMAGNESEMIA | abnormally low Mg (magnesium)
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HYPOCHLOREMIA | abnormally low blood chloride level (eg: alkalosis)
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HYPERCHLOREMIA | abnormally high blood chloride level (eg: acidosis)
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ARTERIAL BLOOD GAS (ABG) | method of evaluating acid-base balance & oxygenation
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pH | 7.35 - 7.45
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PaCO2 | 35 - 45
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PaO2 | 80 - 100
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FLUID VOLUME DEFICIT | fluid/electrolyte disorder caused by failure of the body's homeostatic mechanism to regulate the retention & excretion of body fluids
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FLUID VOLUME EXCESS | fluid/electrolyte disorder by an increase in fluid retention & edema, failure of body's retention & excretion of fluids
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