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nctc 2nd sem final

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– Signs of hyperglycemia   • Fruity/acetone smell to breath, increased pulse, abnormal breathing, etc  
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– Signs of hypoglycemia   • Confusion, irritability, sweating, nervousness, etc  
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• Type I Diabetes Mellitus   • Type I Diabetes Mellitus – Absolute lack of insulin or production of defective insulin – Classic symptoms • Polydipsia • Polyphagia • Polyuria – Results from autoimmune reaction that destroys betal cells of the pancreas – Treated with insulin  
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Type II Diabetes Mellitus   – Insulin deficiency or insulin resistance – Accompanies: obesity, lipid abnormalities, hypertension – Initial treatment is weight loss, life-style changes, regular exercise – Treated with oral antidiabetic meds +/or insulin  
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Digoxin   Most commonly prescribed cardiac glycoside Derived from the digitalis plant Contraindicated in patients with hypersensitivity, ventricular tachycardia and fibrillation, Beriberi heart disease or hypersensitive carotid sinus syndrome  
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Digoxin Available in:   Oral: 125 - 500 mcg (0.125 - 0.5 mg) tablets 50 - 200 mcg (0.05 - 0.2 mg) liquid-filled capsules Parenteral: 100- and 200 mcg (0.1 - 0.2 mg) IV injection  
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Digitalizing:   Administration of loading dose to rapidly bring digoxin levels up to a desirable therapeutic level  
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Maintenance dose after digitalizing   0.125 - 0.5 mg / d  
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Digoxin immune Fab (Digibind)   Antidote for severe toxicity Contraindicated in patients with known hypersensitivity Only available in parenteral form as a 40 mg vial Dose depends on digitoxin level of the blood in conjunction with the patient's weight  
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Common Dig side effects:   CV: arrhythmias (brady- or tachycardia) GI: anorexia, nausea, vomiting, diarrhea CNS: headache, fatigue, malaise, confusion, convulsions Visual: colored vision (green, yellow, or purple), halos, flickering lights  
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