Adenosine
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| Adenosine | Adenocard
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| Machanism of Action | Naturally occurring nucleoside that decreases conduction through the AV node and interrupts AV and SA re-entry pathways thus restoring normal sinus rhythm in patients with SVT
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| Indications | SVT refractory to Vagal maneuvers including Wolff-Parkinson-White (WPW)
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| Contraindications | 2nd and 3rd Degree AV heart blocks, symptomatic Bradycardia, sick sinus syndrome, hypersensitivity
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| Precautions | Place patient in Semi-Fowler position as patients will typically develop arrhythmias at the time of conversionUse caution in patients with Asthma
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| Side Effects | Syncope, dizziness, dyspnea, N/V, headaches, palpitations, chest pain, hypotention and dysrhythmiasSide effects are usually self-limiting due to short half-life
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| Interactions | Patients taking caffeine or xanthines (aminophylline or theophylline) may require larger doses as these drugs antagonize adenosine. Patients on dipyridamole(Persantine) and carbamazepine (tegretol) may need smaller doses of adenosine as these drugs poten
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| Dosage and Route | Adult: 6 mg rapid IVP followed by 10-20ml NS flush (if no conversion after 1-2 min administer) 12mg rapid IVP followed by 10-20ml NS flush (if no conversion after 1-2 min administer) Repeat 12mg rapid IVP followed by 10-20 ml NS flush
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