512-Vaughn-Williams
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| beta blockers | 2 | treat tachyarrhythmias, slow ventricular response in atrial arrythmias, prevent remodeling in HF | fatigue, bronchospasm, hypotension, impotence, mask hypoglycemic Sx in DM, abrupt D/C leads to rebound HTN | SA or AV node dysfunction, asthma, PVD, hypoglycemia
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| amiodarone | 3 | K+ block, beta block, Ca++ block | Oral/IV | skin discoloration, bradycardia/AV block, corneal microdeposits, GI, hepatitis, hypotension, hyperthyroidism, hypothyroidism, insomnia, LFT abnormality, optic neuritis, peripheral neuropathy, photosensitivty, pulmonary fibrosis, Torsades, tremor/ataxia | SV arrhythmia, ventricular arrhythmia | hepatic | CYP2C8, CYP3A4, CYP2C9, CYP2D6, QT prolongation, beta-blockade, warfarin, statins | SA or AV node dysfunction, Prolonged QT interval, lung disease
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| dofetilide | 3 | K+ block | Oral | HA, DZ, Torsades | SV arrhythmias, acute conversion of AF, maintain sinus rhythm in AF | renal | CYP3A4, QT prolongation, metformin, verapamil, trimethoprim | Prolonged QT interval
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| dronedarone | 3 | K+ block, beta block, Ca++ block | Oral | GI, increase SCr, bradycardia, Torsades | SV arrhythmias | NONE | CYP2D6, CYP3A4, QT prolongation, beta blockers, non-DHP CCB | HF, SA or AV node dysfunction, Prolonged QT interval
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| ibutilide | 3 | K+ block | IV | HA, lowers BP, Torsades | SV arrhythmias, acute conversion of AF | NONE | QT prolongation | Prolonged QT interval
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| sotalol | 3 | K+ block, beta block | Oral/IV | DZ, fatigue, GI, bradycardia/AV block, Torsades | SV arrhythmias, ventricular arrhythmias | renal, QT interval | QT prolongations, beta blockade | Prolonged QT interval
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| verapamil | 4 | non-DHP CCB | hypotension, sinus bradycardia, AV block, constipation | SV tachyarrhythmias > ventricular arrhythmias, Afib, PSVT | SA or AV node dysfunction, WPW, constipation
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| diltiazem | 4 | non-DHP CCB | hypotension, sinus bradycardia, AV block, constipation | SV tachyarrhythmias > ventricular arrhythmias, Afib, PSVT | SA or AV node dysfunction, WPW, constipation
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| adenosine | Misc | slows sinus rate & AV node conduction, increase AV node refractoriness | IV push or drip | minimal | PSVT | Cardiac transplant
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| magnesium | Misc | unknown | Torsades |
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| disopyramide | 1a | Na+ block, K+ block, alpha block | Oral | anticholinergic, GI, Torsades, HF | SV arrhythmia, ventricular arrhythmia | hepatic, renal | anticholinergic, QT prolongation, CYP3A4 | HF, Prolonged QT interval, prostatism, glaucoma
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| procainamide | 1a | Na+ block, K+ block | IV | lowers BP, Torsades | SV arrhythmia, ventricular arrhythmia | hepatic, renal | QT prolongation, CYP2D6 | Prolonged QT interval, arthritis
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| quinidine | 1a | Na+ block, K+ block | Oral/IV | GI, lowers BP, Torsades, hepatitis, thrombocytopenia, hemolytic anemia, anticholinergic | SV arrhythmia, ventricular arrhythmia | hepatic, renal | QT prolongation, CYP3A4, CYP2C9, DHP CCB | Prolonged QT interval, diarrhea
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| lidocaine | 1b | Na+ block | IV | sedation, paresthesia, seizures, GI, sinus arrest | ventricular arrythmias > SV arrythmias | hepatic | CYP3A4, CYP2D6, CYP1A2, CYP2C9, antiarrhythmics, beta blockers |
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| mexiletine | 1b | Na+ block | Oral | sedation, paresthesia, GI, ventricular arrythmias | ventricular arrythmias > SV arrythmias | hepatic | CYP2D6, CYP1A2, SSRIs | tremor
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| flecainide | 1c | Na+ block | Oral | blurred vision, DZ, HA, nausea, HF, ventricular arrythmias | SV arrhythmia, ventricular arrhythmia | hepatic, renal | CYP2D6, CYP1A2, QT prolongation, verapamil | HF, Hx of MI
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| propafenone | 1c | Na+ block, beta block | Oral | DZ, bronchospasm, HA, GI, HF, bradiacardia/AV block, ventricular arrhythmias | SV arrhythmia, ventricular arrhythmia | hepatic | CYP2D6, CYP1A2, beta blockers, QT prolongation, SSRIs | asthma, PVD, hypoglycemia
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| digoxin | Misc | increase AV node refractoriness | NTI, hyperkalemia | Afib | SA or AV node dysfunction, WPW
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