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512-Vaughn-Williams

DrugClassMOAFormulationsSide EffectsIndicationsDose AdjustmentD/IC/I
beta blockers 2 treat tachyarrhythmias, slow ventricular response in atrial arrythmias, prevent remodeling in HF fatigue, bronchospasm, hypotension, impotence, mask hypoglycemic Sx in DM, abrupt D/C leads to rebound HTN SA or AV node dysfunction, asthma, PVD, hypoglycemia
amiodarone 3 K+ block, beta block, Ca++ block Oral/IV skin discoloration, bradycardia/AV block, corneal microdeposits, GI, hepatitis, hypotension, hyperthyroidism, hypothyroidism, insomnia, LFT abnormality, optic neuritis, peripheral neuropathy, photosensitivty, pulmonary fibrosis, Torsades, tremor/ataxia SV arrhythmia, ventricular arrhythmia hepatic CYP2C8, CYP3A4, CYP2C9, CYP2D6, QT prolongation, beta-blockade, warfarin, statins SA or AV node dysfunction, Prolonged QT interval, lung disease
dofetilide 3 K+ block Oral HA, DZ, Torsades SV arrhythmias, acute conversion of AF, maintain sinus rhythm in AF renal CYP3A4, QT prolongation, metformin, verapamil, trimethoprim Prolonged QT interval
dronedarone 3 K+ block, beta block, Ca++ block Oral GI, increase SCr, bradycardia, Torsades SV arrhythmias NONE CYP2D6, CYP3A4, QT prolongation, beta blockers, non-DHP CCB HF, SA or AV node dysfunction, Prolonged QT interval
ibutilide 3 K+ block IV HA, lowers BP, Torsades SV arrhythmias, acute conversion of AF NONE QT prolongation Prolonged QT interval
sotalol 3 K+ block, beta block Oral/IV DZ, fatigue, GI, bradycardia/AV block, Torsades SV arrhythmias, ventricular arrhythmias renal, QT interval QT prolongations, beta blockade Prolonged QT interval
verapamil 4 non-DHP CCB hypotension, sinus bradycardia, AV block, constipation SV tachyarrhythmias > ventricular arrhythmias, Afib, PSVT SA or AV node dysfunction, WPW, constipation
diltiazem 4 non-DHP CCB hypotension, sinus bradycardia, AV block, constipation SV tachyarrhythmias > ventricular arrhythmias, Afib, PSVT SA or AV node dysfunction, WPW, constipation
adenosine Misc slows sinus rate & AV node conduction, increase AV node refractoriness IV push or drip minimal PSVT Cardiac transplant
magnesium Misc unknown Torsades
disopyramide 1a Na+ block, K+ block, alpha block Oral anticholinergic, GI, Torsades, HF SV arrhythmia, ventricular arrhythmia hepatic, renal anticholinergic, QT prolongation, CYP3A4 HF, Prolonged QT interval, prostatism, glaucoma
procainamide 1a Na+ block, K+ block IV lowers BP, Torsades SV arrhythmia, ventricular arrhythmia hepatic, renal QT prolongation, CYP2D6 Prolonged QT interval, arthritis
quinidine 1a Na+ block, K+ block Oral/IV GI, lowers BP, Torsades, hepatitis, thrombocytopenia, hemolytic anemia, anticholinergic SV arrhythmia, ventricular arrhythmia hepatic, renal QT prolongation, CYP3A4, CYP2C9, DHP CCB Prolonged QT interval, diarrhea
lidocaine 1b Na+ block IV sedation, paresthesia, seizures, GI, sinus arrest ventricular arrythmias > SV arrythmias hepatic CYP3A4, CYP2D6, CYP1A2, CYP2C9, antiarrhythmics, beta blockers
mexiletine 1b Na+ block Oral sedation, paresthesia, GI, ventricular arrythmias ventricular arrythmias > SV arrythmias hepatic CYP2D6, CYP1A2, SSRIs tremor
flecainide 1c Na+ block Oral blurred vision, DZ, HA, nausea, HF, ventricular arrythmias SV arrhythmia, ventricular arrhythmia hepatic, renal CYP2D6, CYP1A2, QT prolongation, verapamil HF, Hx of MI
propafenone 1c Na+ block, beta block Oral DZ, bronchospasm, HA, GI, HF, bradiacardia/AV block, ventricular arrhythmias SV arrhythmia, ventricular arrhythmia hepatic CYP2D6, CYP1A2, beta blockers, QT prolongation, SSRIs asthma, PVD, hypoglycemia
digoxin Misc increase AV node refractoriness NTI, hyperkalemia Afib SA or AV node dysfunction, WPW
Created by: kcapizzi
 

 



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