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17mech of breathing,18gas exchg/transport,19kidneys 20 fluid/elec balance

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Question
Answer
4 functions of the respiratory system   exchange gases, regulate pH, protect pathogens/irritants, vocalization  
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upper respiratory system   mouth, nasal cavity, larynx, pharynx  
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lower respiratory system   trachea, primary bronchioles, alveloi  
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inspiratory muscles   external intercostals, sternocleidomastoids, scalenes  
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expiratory muscles   internal intercostals, abdominals  
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processes of external respiration   3exchanges-air between lungs & atm, O2& CO2 lungs and blood,gases blood & cells Transport O2 & CO2 by blood  
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Oxygen molecule from air to lung   mouth, nose, pharynx, larynx,trachea, primary bronchi, branching bronchi, bronchioles, alveoli  
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functions of pleural fluid   allow membranes to slide across each other, holds lungs tight against thoracic wall  
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Alveolar type I cells   exchange gases  
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Alveolar type II cells   secrete surfactant  
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Boyle's Law   breathing decrease volume=increase pressure  
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Law of Laplace   Larger Alveoli have Lower pressure  
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Dalton's Law   EGAD-exchange of gas is dalton's  
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respiratory system created volume change   diaphram contracts, volume up, relaxes, volume down  
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The maximum volume of air that can be forcibly expired after normal expiration   expiratory reserve volume  
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The maximum volume of air that can be forcibly ispired after normal inspiration   inspiratory reserve volume  
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The volume of air that remains in the respiratory system afer a forced expiration   residual volume  
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The volume of air moved during normal quiet breathing   tidal volume  
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Vital capacity(VC) air moved in/out per min   IRV+ERV+TV  
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Total lung capacity(TLC)vol air in lungs after max inhalation   IRV+TV+ERV+RV  
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Functional residual capacity(FRC) vol air left after tidal exhalation   ERV+RV  
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Inspiratory capacity(IC) vol inhaled after tidal expiration   IRV+TV  
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components to conditioning air before reaches alveoli   warm air, add moisture, filter foreign mat.  
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physical properties of lungs   compliance(stretch)elasticity(recoil)surface tension(pressure w/in alveoli)  
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Air moves from   high to low pressure  
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forced expiration muscles   internal intercostals, abs  
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function of surfactant   prevents surface tension from collapsing alveoli  
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bronchoconstriction   decreased diameter & increased resistance  
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bronchodialation   increased diameter & decreased resistance  
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parameters that regulate diameter of bronchiles   paracrines, nervous system control, hormones  
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CO2 & epi   bronchodialation  
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histamine & parasympathetic NS   bronchoconstriction  
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receptor epi binds to in brochioles   B2  
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total pulmonary ventilation   volume of air moved into & out of lungs/min  
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alveolar ventilation   volume of air reaching alveoli/min  
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anatomic dead space   volume of air that does NOT reach alveoli  
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Ventilation-perfusion matching in lungs   local regulation of airflow & blood flow changing diameter of arterioles & bronchioles  
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bronchiole diameter as CO2 increases   bronchodialation  
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pulmonary arteriole diameter as O2 decreases   contstrict  
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apnea   cessation of breathing  
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dyspnea   difficulty breathing  
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factors that influend diffusion of gases between alveoli & blood   surface areas of alveoli, diffusion distance, membrance thickness, [c] gradient of gas  
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O2 transported to the blood   98% bound to Hb, 2% in plasma  
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structure of Hb   4 globular protein + 1 heme  
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chemical element essential for Hb synthesis   Fe  
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hypoxia   too little O2  
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hypercapnia   too much CO2  
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categories of problems from hypoxia   inadequate O2 to alveoli, prob O2 exchange between alveoli & pulm caps, inadequate transport O2 in blood  
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Alveolar PO2 low because of   high altitude or hypoventilation  
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relationship between altitude and PO2   increase in altitude, decrease in PO2  
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anemic hypoxia   Hb with low O2(blood loss, anemia, CO poisoning)  
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ischemic hypoxia   reduction in blood flow (heart failure,shock)  
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histotoxic hypoxia   failure of cells to use O2 properly(cyanide poisoning)  
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oxyhemoglobin dissociation curve   gives % Hb sites that have bound O2 at diff PO2 loading and unloading of O2x=resting cell y= % O2 sat of Hb  
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causes shift to left on oxyhemoglobin curve   O2 not bound to Hb-O2 increased affinity of Hb for O2  
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causes shift to right on oxyhemoglobin curve   increase in CO2-decreased affinity of Hb for O2  
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3 ways CO2 transported in blood   HCO3, dissolved CO2(plasma, carbaminohemoglobin(binds to)  
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equation in which CO2 converted into HCO3   Co2 + H2O yields H2Co3 yeilds H + HCO3  
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enzyme that catalyzes CO2 conversion   carbonic anhydrase(CA)  
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chloride shift   CO2 diffuses into RBC ain in Cl ion inside blood, shifts rxn right RBC become more + HCO3 diffuses into blood  
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where reverse chloride shift occurs   alveoli  
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relationship between CO2 and pH levels in blood   CO2 increases pH decreases-inverse relationship  
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respiratory acidosis   increased CO2 retention-accum of carbonic acid & drop in pH  
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respiratory alkalosis   too little CO2 increase in pH (hyperventilate)  
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central chemoreceptors   medulla-CO2, PO2, pH- increases ventilation  
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peripheal chemoreceptors   carotid/aortic bodies-PO2, pH, PCO2-increase ventilation  
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respiratory center   located in medulla and pons (CNS)  
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central chemoreceptors respond to increased PCO2   increase PCO2=decreased pH of CSF receptors in medulla send messages to respiratory center medulla send signal via motor neurons to resp nucleus and ventilation increases  
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functions of kidneys   regulate extracellular fluid volume & BP, reg somolarity, mainain ion balance, homeostatic reg of pH, excrete wasited, produce hormones  
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structures of urinary system in sequence   kids, ureters, bladder, urethra  
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3 filtration barriers cross move from plasma into Bowman's cap   glomeruli consists of fenestrated caps, basal lamina, podocytes  
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forces promote glomerular filtration   hydrostatic of glomerus  
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forces oppose glomerular filtration   colloid pressure, hydrostatic fluid pressure inside Bowman's cap  
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GCF   Glomerular Filtration Rate - 125mL/min or 180L/day  
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cortical nephrons   almost completely contained w/in cortex  
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juxtamedullary nephrons   long loops of H dip down into medulla, vasta recta here  
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renal corpuscle   combo of glomerulus and Bowman's cap  
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renal portal system   afferent art to glomeruli to efferent art to peritubular caps  
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average amount of urine leaves body per day   1-2L min 400 mL  
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filtration fraction   % of total plasma volume that is filtered into nephron  
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factors that influence GFR most   net filtration pressure, filtration coefficient  
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relationship between BP and GFR   BP up GFR up  
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mechanisms that goven autoregulation of GFR   myogenic response, tubloglomerular feedback, hormones & automoatic hormones  
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myogenic response   maintain constant GFR at local level  
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hormones that influence arteriolar resistance   Angiotensin II, prostoglandin  
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NS that innvervates afferent arteriole   sympathetic  
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ion that plays key role in bulk reabsorption proximal tubule   Na+  
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transepithelial transport   substances cross both apical and basolateral membrane  
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paracellular pathway   substances pass through th junction between two adjacent cells  
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properites of mediated transport   saturation, competition, specificity  
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below saturation, the rate of transport is propotional to   [substrate]  
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The rated of trasnport at saturation is also know as   transport maximum  
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For a particular substance, plasma concentration at which that substrate first appears in the urine is known as the   renal threshold  
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does filtration exhibit saturation   NO  
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glucose in the urine   glycosuria  
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renal excretion formula   filtration - reabsorption + secretion  
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In renal secretion, molecules move from the ___ to the ____   EC fluid, nephron  
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renal clearance   rate at which a solute disappears from the body by excretion on metabolism  
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micturition   urination  
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NS involved in micturition reflex   Parasymp-contracts bladder, somatic moroe-controls external sphincter  
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2 sphincters in micturition   internal, external  
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electolytes that must be regulated by body   Na, K, Ca, H, HCO3  
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Ascending L of H permeability to H2O & NaCl   permeable to NaCl and K+, impermeable to H2O  
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Descending L of H permeability to H2O & NaCl   only H2O absorbed  
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ion primary determinant of ECF volume   Na+  
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ion primary determinant of pH   H--makes more acidic  
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Vasopressin   net result=h2O reabsorp acts in collecting duct  
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What causes vasopressin to be released from post. pit   decreased BP or increased ECF osmolarity  
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countercurrent multiplier   arrangement of L of H that concentrates solute in renal medulla.  
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addition of NaCl raises osmolarity   triggers vasopressin & thirst  
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vasa recta   surrounds loop and removes H2O and NaCl is recycled  
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effects of angiotensin II beyond stimulating aldosterone secretion   affects BP, vasoconstrictor, stimulates thirst,increases symp activity to heart & bv  
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ANP   Atrial Natriuretic Peptide produced in atria of heart  
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stimulus for ANP secretion and effects   stretch of atria stimulates and it enhances Na+ and H2O loss  
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hyperkalemia   too much K+  
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hypokalemia   too little K+  
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what happens when K concentrations are out of balance   cardiac arrhythmias  
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how does body compensate for decrease in BP(dehydration)   baroreceptors increase by vasoconstriction increase HR, increase contraction of heart, vasopressin released decreases BP  
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mechanisms body uses to cope with pH changes   1st-buffers 2nd-ventilation 3rd renal regulation of H+ and HCO3  
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how kidneys alter pH   acidosis-secrete H+ and reabsorb HCO3 alkadosis-reabsorb H+ and secrete HCO3  
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mechanisms activated when blood osmolarity increases(dehydration)   hypo stimulates vasopressin reabsorbtion of H2O(collecting duct) to blood conserve H2O and thirst initiated  
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