Pharm. Ch 17-18 by lilk8tob
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| drugs that stimulate the sympathetic nervous system. | adrenergics
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| Adrenergics are also called: (2) | adrenergic agonists or sympathomimetics because they mimic the effects of the sympathetic neurotransmitters norepinephrine and epinephrine
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| adrenergic receptors that are further divided into alpha1- and alpha2-adrenergic receptors and are differentiated by their location on nerves | alpha-adrenergic receptors
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| Bodily functions that are involuntary and result from physiologic activity of the ANS. | autonomic functions
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| Controls autonomic bodily functions | autonomic nervous system (ANS)
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| Located on postsynaptic effector cells- the cells, muscles, and organs that the nerves stimulate. | Beta-adrenergic receptors
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| Beta1-adrenergic receptors are primarily in: | the heart
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| beta2-adrenergic receptors are located in the: | smooth muscle of the bronchioles and arterioles and in visceral organs
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| substances that can produce a sympathomimetic response. They are either endogenous catecholamines (such as epinephrine, norepinephrine, and dopamine) or synthetic catecholamines. | catecholamines
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| adrenergic receptors that, when stimulated by dopamine, cause the renal, mesenteric, coronary, and cerebral arteries to dilate and the flow of blood to increase | dopaminergic receptors
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| pupillary dilation, whether natural (physiologic) or drug-induced | mydriasis
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| topically applied eye medications | ophthalmics
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| refers to an increased heart rate | positive chronotropic effect
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| causes an increase in conduction through the atrioventricular node | positive inotropic effect
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| the space between the nerve ending and the effector organ | synaptic cleft
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| paroxysmal chest pain caused by myocardial ischemia | angina
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| drugs that bind to adrenergic receptors and inhibit or block neurotransmitters | antagonists
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| the characteristic of beta-blockers to inhibit stimulation of the heart by circulating catecholamines | cardioprotective
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| beta-blocking drugs that are selective for beta1-adrenergic receptors. | cardioselective beta-blockers
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| cardioselective beta-blockers are also called: | beta1-blocking agents
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| irregular heartbeat | dysrhythmia
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| leaking of fluid from the blood vessel into the tissues | extravasation
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| the production of glucose from glycogen in the liver, which is reduced by beta-blockers | glycogenolysis
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| action of agents within the beta-blocking class. A drug that mimics the activity of the adrenergic system | intrinsic sympathomimetic activity (ISA)
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| attraction to lipid or fat | lipophilicity
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| beta-blocking drugs that block both beta1- and beta2-adrenergic receptors | nonselective beta-blockers
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| abnormally low blood pressure occuring when a person assumes the standing position | orthostatic hypotension
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| drugs used to treat postpartum and postabortion bleeding caused by uterine relaxation and enlargement. They stimulate the smooth muscle of the uterus to contract | oxytocics
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| vascular tumor that secretes norepinephrine and stimulates the CNS | pheochromocytoma
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| another name for adrenergic antagonists | sympatholytics
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| system of classifying antidysrhythmic agents | Vaughan Williams classification
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| Albuterol (*) | Ventolin
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| Epinephrine (*) | Adrenalin
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| Pseudoephedrine (*) | Afrin
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| Dobutamine (*) | Dobutrex
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| Albuterol is a (category) | selective beta2 adrenergic
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| Epinephrine is a (cat.) | natural mixed alpha and beta
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| Pseudoephedrine is a (cat.) | stereoisomer of ephedrine
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| Dobutamine is a (cat.) | beta1-selective vasoactive adrenergic drug similar to natural dopamine
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| Albuterol effect | bronchodilator
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| Epiniphrine effects | vasoconstriction, increased BP, cardiac stimulation, dilation of bronchioles
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| Pseudoephedrine effect | nasal decongestant
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| Dobutamine effect | increases cardiac output by increasing contractility (positive inotropy), which increases stroke volume
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| metaprolol (*) | Lopressor
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| propranolol (*) | Inderal
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| sotalol (*) | Betapace
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| phentolamine (cat.) | alpha blocker
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| prazosin (cat.) | alpha1-adrenergic blocker
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| metaprolol (cat.) | beta1-blocker
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| propranolol (cat.) | nonselective beta1 and beta2 blocker
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| sotalol (cat.) | nonselective beta blocker
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| phentolamine effect | reduces peripheral vascular resistance
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| phentolamine used to treat | hypertension, pheochromocytoma, extravasation of vasopressors
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| prazosin effect | relaxes & dilates the vasculature & smooth muscle around the prostate
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| prazosin uses | hypertension, urinary obstruction in men w/ BPH
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| metaprolol uses | post-MI, hypertension, early MI
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| propranolol uses | angina, hypertension, dysrhythmias, post MI, migraine, tremor, pheochromocytoma
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| sotalol effect | antidysrhythmic
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| sotalol uses | difficult to treat dysrhythmias
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lilk8tob
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