HIV brand/generic review for CPJE 2016
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| Truvada | tenofovir 300mg/ emtricitabine 200mg | q 24h | 2 NRTIs
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| Epzicom | lamivudine 300mg/abacavir 600mg | q 24h | 2 NRTIs
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| NRTI class toxicities | Severe hepatomegaly with steatosis and Lactic acidosis |
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| HLA-B*5701 | Abacavir risk for hypersensitivity |
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| NRTIs which case pancreatitis, peripheral neuropathy, and higher risk of lactic acidosis | "D" drugs Stavudine and didanosine |
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| Retrovir | Zidovudine | 300mg BID | NRTI
without regards to meals
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| Epivir | Lamivudine | 300mg daily or 150mg BID | NRTI
without regards to meals
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| Ziagen | Abacavir | 600mg daily or 300mg BID | NRTI
without regards to meals
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| Videx | Didanosine | > 60kg 400mg daily < 60 kg 250mg daily Tenofovir increases levels | NRTI
Take 30 min before or 2 hours after meals
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| Zerit | Stavudine | > 60 kg 400mg BID; < 60 kg 30mg BID | NRTI
without regards to meals
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| Viread | Tenofovir | 300mg daily | NRTI
without regards to meals
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| Emtriva | Emtricitabine | 200mg daily | NRTI
without regards to meals
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| NNRTI class toxicities | rash and hepatic impairment | all must be dose adj for hepatic impairment | All are CYP inducers or inhibitors
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| Sustiva | Efavirenz | 600mg qhs | NNRTI
empty stomach
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| Viramune | Nevirapine | 200mg BID | NNRTI
without regards to meals
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| Intelence | Etravirine | 200mg BID | NNRTI
Following a meal
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| Rescriptor | Delavirdine | 400mg q8h | NNRTI
without regards to meals
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| Protease Inhibitor class toxicities | fat maldistribution, hyperglycemia, hyperlipidemia, hypertriglyceridemia |
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| Kaletra | Lopinavir 200mg/ ritonavir 100mg | 400mg/100mg BID or 800mg/200mg once daily (naive pts only) | PI
tab: without regards to meals
liquid: with food
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| Viracept | Nelfinavir | 1250mg BID | PI
with food
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| Reyataz | Atazanvir | ATV 300mg + RTV 100mg once daily or 400mg unboosted once daily (naive) | PI
with food
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| Lexiva | Fosamprenavir | 1400mg BID or 1400mg + RTV100mg once daily (naive) 700mg + RTV 100mg BID (exp) | PI
without regards to meals
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| Invirase | saquinavir | 1000mg + RTV 100mg BID | PI
within 2 hours of meal
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| Prezista | darunavir | 800mg + RTV 100mg once daily (naive) 600mg + RTV 100mg BID (exp) | PI
with food
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| Aptivus | tipranavir | 500mg + RTV 200mg BID | PI
without regards to meals
Keep refrigerated
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| Norvir | Ritonovir | 600mg BID as single PI | PI
take with food
Keep refrigerated
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| Crixivan | Indinavir | 800mg q8h or 800mg + 100mg RTV q 12h | PI
when boosting, without regards to meals; otherwise without food
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| Fuzeon | Enfuvirtide | 90mg SQ q 12h | Entry inhibitor
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| HARRT in pregnancy | Drugs to avoid: efavirenz, stavudine, didanosine | IV zidovudine should be given during labor |
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| Triumeq | Lamivudine 300mg/ Abacavir 600mg/ Dolutegravir50mg | 1 tab daily | integrase inhibitor
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| Atripla | Tenofovir 300mg/ Emtricitabine 200mg/ Efavirenz 600mg | 1 tab daily | 2 NRTIs
1 NNRTI
take on empty stomach
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| Complera | Tenofovir 300mg/ Emtricitabine 200mg/ Rilpivirine 25mg | 1 tab daily | 2 NNRTIs
1 NNRTI
take with food
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| Stribild | Tenofovir 300mg/ Emtricitabine 200mg/ Elvitegravir 150mg/ cobicistat 150mg | 1 tab daily | 2 NNRTIs
1 Integrase inhibitor
take with food
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| Genvoya | Tenofovir alafenamide 10mg/ Emtricitabine 200mg/ Elvitegravir 150mg/ cobicistat 150mg | 1 tab daily | 2 NNRTIs
1 Integrase inhibitor
take with food
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| Edurant | Rilpivirine 25mg | 1 tab daily | NNRTI
with food
keep in original container
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| Vitekta | Elvitegravir150mg | 150mg daily with ritonavir or cobicistat | Integrase inhibitor
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| Tivicay | dolutegravir | 50mg once daily (naive) 50mg BID (exp) | Integrase inhibitor
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| Isentress | Raltegravir | 400mg BID | Integrase inhibitor
with food
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| Dutrebis | Raltegravir/lamivudine | 150/300mg | Integrase inhibitor and NRTI
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| Combivir | zidovudine 300mg/ lamivudine 150mg | q 12h | 2 NRTIs
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| Trizivir | Zidovudine 300mg/ lamivudine 150mg/ Abacavir 300mg | q12h | 3 NRTIs
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