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HIV brand/generic
HIV brand/generic review for CPJE 2016
Question | Answer | Dose | Drug Class |
---|---|---|---|
Truvada | tenofovir 300mg/ emtricitabine 200mg | q 24h | 2 NRTIs |
Epzicom | lamivudine 300mg/abacavir 600mg | q 24h | 2 NRTIs |
NRTI class toxicities | Severe hepatomegaly with steatosis and Lactic acidosis | ||
HLA-B*5701 | Abacavir risk for hypersensitivity | ||
NRTIs which case pancreatitis, peripheral neuropathy, and higher risk of lactic acidosis | "D" drugs Stavudine and didanosine | ||
Retrovir | Zidovudine | 300mg BID | NRTI without regards to meals |
Epivir | Lamivudine | 300mg daily or 150mg BID | NRTI without regards to meals |
Ziagen | Abacavir | 600mg daily or 300mg BID | NRTI without regards to meals |
Videx | Didanosine | > 60kg 400mg daily < 60 kg 250mg daily Tenofovir increases levels | NRTI Take 30 min before or 2 hours after meals |
Zerit | Stavudine | > 60 kg 400mg BID; < 60 kg 30mg BID | NRTI without regards to meals |
Viread | Tenofovir | 300mg daily | NRTI without regards to meals |
Emtriva | Emtricitabine | 200mg daily | NRTI without regards to meals |
NNRTI class toxicities | rash and hepatic impairment | all must be dose adj for hepatic impairment | All are CYP inducers or inhibitors |
Sustiva | Efavirenz | 600mg qhs | NNRTI empty stomach |
Viramune | Nevirapine | 200mg BID | NNRTI without regards to meals |
Intelence | Etravirine | 200mg BID | NNRTI Following a meal |
Rescriptor | Delavirdine | 400mg q8h | NNRTI without regards to meals |
Protease Inhibitor class toxicities | fat maldistribution, hyperglycemia, hyperlipidemia, hypertriglyceridemia | ||
Kaletra | Lopinavir 200mg/ ritonavir 100mg | 400mg/100mg BID or 800mg/200mg once daily (naive pts only) | PI tab: without regards to meals liquid: with food |
Viracept | Nelfinavir | 1250mg BID | PI with food |
Reyataz | Atazanvir | ATV 300mg + RTV 100mg once daily or 400mg unboosted once daily (naive) | PI with food |
Lexiva | Fosamprenavir | 1400mg BID or 1400mg + RTV100mg once daily (naive) 700mg + RTV 100mg BID (exp) | PI without regards to meals |
Invirase | saquinavir | 1000mg + RTV 100mg BID | PI within 2 hours of meal |
Prezista | darunavir | 800mg + RTV 100mg once daily (naive) 600mg + RTV 100mg BID (exp) | PI with food |
Aptivus | tipranavir | 500mg + RTV 200mg BID | PI without regards to meals Keep refrigerated |
Norvir | Ritonovir | 600mg BID as single PI | PI take with food Keep refrigerated |
Crixivan | Indinavir | 800mg q8h or 800mg + 100mg RTV q 12h | PI when boosting, without regards to meals; otherwise without food |
Fuzeon | Enfuvirtide | 90mg SQ q 12h | Entry inhibitor |
HARRT in pregnancy | Drugs to avoid: efavirenz, stavudine, didanosine | IV zidovudine should be given during labor | |
Triumeq | Lamivudine 300mg/ Abacavir 600mg/ Dolutegravir50mg | 1 tab daily | integrase inhibitor |
Atripla | Tenofovir 300mg/ Emtricitabine 200mg/ Efavirenz 600mg | 1 tab daily | 2 NRTIs 1 NNRTI take on empty stomach |
Complera | Tenofovir 300mg/ Emtricitabine 200mg/ Rilpivirine 25mg | 1 tab daily | 2 NNRTIs 1 NNRTI take with food |
Stribild | Tenofovir 300mg/ Emtricitabine 200mg/ Elvitegravir 150mg/ cobicistat 150mg | 1 tab daily | 2 NNRTIs 1 Integrase inhibitor take with food |
Genvoya | Tenofovir alafenamide 10mg/ Emtricitabine 200mg/ Elvitegravir 150mg/ cobicistat 150mg | 1 tab daily | 2 NNRTIs 1 Integrase inhibitor take with food |
Edurant | Rilpivirine 25mg | 1 tab daily | NNRTI with food keep in original container |
Vitekta | Elvitegravir150mg | 150mg daily with ritonavir or cobicistat | Integrase inhibitor |
Tivicay | dolutegravir | 50mg once daily (naive) 50mg BID (exp) | Integrase inhibitor |
Isentress | Raltegravir | 400mg BID | Integrase inhibitor with food |
Dutrebis | Raltegravir/lamivudine | 150/300mg | Integrase inhibitor and NRTI |
Combivir | zidovudine 300mg/ lamivudine 150mg | q 12h | 2 NRTIs |
Trizivir | Zidovudine 300mg/ lamivudine 150mg/ Abacavir 300mg | q12h | 3 NRTIs |