Seizures
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| target phenytoin level | 10-20 mg/dL
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| HLA-B*1502 and HLA-A*3101 are gene mutations associated with increased risk of using which seizure medication | CBZ - HLA-B*1502 increases risk of steven johnson syndrome. most common in asians and indian patients TESTING RECOMMENDED. HLA-A*3101 increase in hypersensitivity syndrom e and maculopapular rash. north european and japanese mnostly. TESTING NOT REC.
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| conversion of fosphenytoin to phenytoin equivalents | 1 mg phenytoin = 1.5 mg fosphenytoin= 1 mg phenytoin equivalents
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| max infusion rate for phenytoin | 150 mg PE/min
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| emergent drugs for status epilepticus. give to stop seizure. | diazepam, lorazepam or midazolam
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| urgent drugs for status epilepticus. give after emergent meds to prevent further seizures | phenytoin, fosphenytoin, phenobarbital, valproic acid, levetiracetam, lacosamide,
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| options for refractory status epilepticus | pentobarb infusion, thiopental infusion, midazolam infusion, propofol infusion
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| common adverse effects for carbamazepine | hyponatremia, delayed rash, blood dyscrasias. SIADH
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