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BCPS study guide

Seizures

QuestionAnswer
target phenytoin level 10-20 mg/dL
HLA-B*1502 and HLA-A*3101 are gene mutations associated with increased risk of using which seizure medication CBZ - HLA-B*1502 increases risk of steven johnson syndrome. most common in asians and indian patients TESTING RECOMMENDED. HLA-A*3101 increase in hypersensitivity syndrom e and maculopapular rash. north european and japanese mnostly. TESTING NOT REC.
conversion of fosphenytoin to phenytoin equivalents 1 mg phenytoin = 1.5 mg fosphenytoin= 1 mg phenytoin equivalents
max infusion rate for phenytoin 150 mg PE/min
emergent drugs for status epilepticus. give to stop seizure. diazepam, lorazepam or midazolam
urgent drugs for status epilepticus. give after emergent meds to prevent further seizures phenytoin, fosphenytoin, phenobarbital, valproic acid, levetiracetam, lacosamide,
options for refractory status epilepticus pentobarb infusion, thiopental infusion, midazolam infusion, propofol infusion
common adverse effects for carbamazepine hyponatremia, delayed rash, blood dyscrasias. SIADH
Created by: mjuhlin
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