HIV
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show | Truvada (emtricitabine/tenofovir) 300mg/200mg QD
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show | zidovudine
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normal CD4 count | show 🗑
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show | 30%
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show | increase 50-100/mm^3 annually
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CD4 count diagnostic of AIDS (stage 3 HIV) | show 🗑
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show | documentation of an AIDS defining condition along with laboratory confirmation of HIV
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symptoms of acute/primary HIV infection | show 🗑
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show | if CD4 count <200
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show | flu, pneumococcal (once), Hep B (in all susceptible) and Hep A (if at high risk)
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show | 6 weeks with zidovudine 4 mg/kg/dose Q12H. if mom didn't take ART during preggers add nevirapine at birth and repeat at 48 hours then 96 hours after the second dose, repeat.
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what HIV drug should be avoided in women of childbearing age to avoid first trimester exposure | show 🗑
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how long should post exposure prophylaxis continue and how soon after exposure should it start | show 🗑
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show | raltegravir PLUS Truvada (emtricitabine/tenofovir) [occupational]. no preference for ART if non-occupational other than that it be potent combination ART.
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in a low risk HIV positive pt, when should ART be initiated | show 🗑
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what are the principles of HIV opportunistic infections | show 🗑
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preferred treatment for PCP | show 🗑
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show | 150-PCO2-PO2
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show | clinda + primaquine; pentamidine; trimethoprim + dapsone; atovaquone
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show | fluconazole 200 mg QD
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show | positive CSF cultures, CSF india ink, CSF cryptococcal antigen titer, elevated opening pressure >20, serum cryptococcal antigen more than 1:8
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preferred treatment for cryptococcus meningitis | show 🗑
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treatment for CMV infections | show 🗑
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show | secondary is required fo rall. can d/c when CD4 ct is >100 for 3-6 months or longer with ART. primary ppx not recommended but if cd4 ct is <50 recommend funduscopic exam regularly
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standard therapy for toxoplasmosis | show 🗑
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prophylaxis for toxoplasmosis | show 🗑
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treatment for latent TB in pts NOT coinfected with HIV | show 🗑
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treatment for latent TB in pts coinfected with HIV | show 🗑
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show | isoniazid, rifampin, pyrazinamide and ethambutol for 2 months followed by isoniazid and rifampin for 4 more months
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treatment for active TB in pt coinfected with HIV | show 🗑
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show | 1 L NS for 24 hrs or 500 ml before and after dose. avoid diuretics and liberalize salt intake
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show | dilute to 0.1 mg/ml and infuse over at least 4 hours. use a central site and may add heparin
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show | amp B induces PGE synthesis. hydrocortisone or ibuprofen may help. ASA/APAP/benadryl have not been shown to help but were also not specifically studied
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treatment of rigors for amp B | show 🗑
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why is there no renal adjustment dose for voriconazole? | show 🗑
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show | rifampin, rifabutin, carbamazepine, barbituates, sirolimus
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show | tac decrease dose by 2/3. cyclosporine decrease dose by 1/2
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