Spasticity Article
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| Spasticity affects how many people world wide? | 12 mill
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| Following a stroke, what percentage of people experience spasticity? | 65%
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| Historically what are the most common oral meds used to treat spasticity? | diazepam, dantrolene sodium, and baclofen
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| What is the oldest med still used for spasticity? | diazepam(valium)
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| How does diazepam work? | it increase inhibitory effects of GABA
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| Diazepam can produce fatigue and drowsiness at the higher dosages required to manage spasticity because why? | b/c of its depressive CNS effects
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| What are the effects of diazepam? | provoke sedation,
reduced motor coordination, and impair intellect, attention, and memory, and physiological addiction
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| What is the site of action for diazepam? | Brainstem reticular formation and spinal
polysynaptic pathways.
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| What is the site of action for dantrolene sodium? | Skeletal muscle calcium stores
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| Dantrolene sodium is a peripherally acting _________. | skeletal muscle relaxant
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| What is the main risk associated with dantrolene sodium? | hepatoxicity
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| Drowsiness, confusion, headache, and lethargy are adverse effects of what drug? | Oral baclofen
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| What is the site of action for oral baclofen? | GABA-b receptors
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| The ultimate effect of baclofen is what? | decreased activation of the alpha motorneuron.
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| Why is oral administration of baclofen frequently ineffective in controlling severe spasticity? | because of its systemic side effects
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| Why is intrathecal Baclofen more effective than oral baclofen? | it is more effective at crossing the blood brain barrier, and has fewer systemic side effects
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Created by:
txst spr 2009
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