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Pharmacology

Spasticity Article

QuestionAnswer
Spasticity affects how many people world wide? 12 mill
Following a stroke, what percentage of people experience spasticity? 65%
Historically what are the most common oral meds used to treat spasticity? diazepam, dantrolene sodium, and baclofen
What is the oldest med still used for spasticity? diazepam(valium)
How does diazepam work? it increase inhibitory effects of GABA
Diazepam can produce fatigue and drowsiness at the higher dosages required to manage spasticity because why? b/c of its depressive CNS effects
What are the effects of diazepam? provoke sedation, reduced motor coordination, and impair intellect, attention, and memory, and physiological addiction
What is the site of action for diazepam? Brainstem reticular formation and spinal polysynaptic pathways.
What is the site of action for dantrolene sodium? Skeletal muscle calcium stores
Dantrolene sodium is a peripherally acting _________. skeletal muscle relaxant
What is the main risk associated with dantrolene sodium? hepatoxicity
Drowsiness, confusion, headache, and lethargy are adverse effects of what drug? Oral baclofen
What is the site of action for oral baclofen? GABA-b receptors
The ultimate effect of baclofen is what? decreased activation of the alpha motorneuron.
Why is oral administration of baclofen frequently ineffective in controlling severe spasticity? because of its systemic side effects
Why is intrathecal Baclofen more effective than oral baclofen? it is more effective at crossing the blood brain barrier, and has fewer systemic side effects
Created by: txst spr 2009