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Valdeny Article

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Liver size and blood flow decreases with age by __ to ___%   17-46  
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The CYP system metabolizes over ______ of all drugs?   half  
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Why are older adults at higher risk for CYP450-related drug interactions and adverse effects?   because of polypharmacy  
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The CYP3A4 isozyme decline by approximately ___% annualy.   8  
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Why is the decline of the CYP3A4 isozyme clinically relevant?   Because more than 50% of drugs metabolized by the CYP system require the CYP3A4 isozyme.  
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Renal function declines by __ to __% with age.   35-50  
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Creatinine clearance in older adults id a good measure for what?   glomerular filtration rate  
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T or F. For older adults lower doses of opioids are recommended.   True  
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Acetaminophen increases hepatic toxicity if the total amount exceeds_________.   4 grams in 24 hours  
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Antihistamines, antipsychotics, antidepressants, antihypertensives, anticonvulsants, and opiods are considered to be _____ depressants.   CNS  
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What is the most common hypnotic used by older adults?   benzodiazepine  
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Acutely benzodiazepines can cause what?   anterograde amnesia, delirium, paradoxical agitation  
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Chronic use of benzodiazapine can result in what?   falls and resultant fractures  
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the most prevalent form of drug induced osteoporosis is caused by which drug?   glucocorticoids  
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The elderly make up ___% of the population yet consume ____ of prescription meds and over _____ of OTC meds.   12, one third, half  
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In elderly patients, are the effects of drugs longer or shorter in duration and why?   longer due to the decrease in hepatic and renal function  
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In elderly patients, are the effects of drugs more or less dramatic?   more  
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Created by: txst spr 2009
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