Anti Inflam Drugs
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| What is Anti-inflamation | Anti-inflammation or anti inflammatory refers to the property of a substance or treatment that reduces inflammation or swelling.
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| Five cardinal signs of inflammation | Erythema (red)
Edema (swollen)
Heat (hot)
Pain
Loss of function
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| What is Cyclooxygennase (COX) ENZYME pathway | COX enzymes convert Arachadonic acid to prostaglandins(which triggers pain).
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| COX 1 prostaglandins mechanism | 1.Protects Stomach lining (maintain kidney function, in the ovary and GI tract)
2.Regulates platelet aggregation
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| COX 2 prostaglandins mechanism | 1.Trigger inflammation and pain (play a main role in inflammation and pain)
2.Inhibit platelet aggregation
3. Fever
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| Whats the primary function of NSAIDS | To inhibit COX 1 and 2....(prostaglandins levels lower)
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| NSAIDS DRUGS (NON-SELECTIVE) | AFFECTS COX 1 AND COX 2
1.Decrease platelet aggregation
2.Anti Inflammatory effects
3.Anti pyretic effect
4.Analgesic effects
eg Alleve, Motrin(ibuprophin) ,Ketorolac
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| Aspirin blocks COX 1 by | 1.Loss of stomach lining =ulcer
2.Prevents blood clotting
3. kidney dysfunction
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| NSAIDS block COX 2 by | 1. Reducing pain
2.Suppressing inflamation
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Created by:
amoniffa
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