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Anti Inflam Drugs

What is Anti-inflamation Anti-inflammation or anti inflammatory refers to the property of a substance or treatment that reduces inflammation or swelling.
Five cardinal signs of inflammation Erythema (red) Edema (swollen) Heat (hot) Pain Loss of function
What is Cyclooxygennase (COX) ENZYME pathway COX enzymes convert Arachadonic acid to prostaglandins(which triggers pain).
COX 1 prostaglandins mechanism 1.Protects Stomach lining (maintain kidney function, in the ovary and GI tract) 2.Regulates platelet aggregation
COX 2 prostaglandins mechanism 1.Trigger inflammation and pain (play a main role in inflammation and pain) 2.Inhibit platelet aggregation 3. Fever
Whats the primary function of NSAIDS To inhibit COX 1 and 2....(prostaglandins levels lower)
NSAIDS DRUGS (NON-SELECTIVE) AFFECTS COX 1 AND COX 2 1.Decrease platelet aggregation 2.Anti Inflammatory effects 3.Anti pyretic effect 4.Analgesic effects eg Alleve, Motrin(ibuprophin) ,Ketorolac
Aspirin blocks COX 1 by 1.Loss of stomach lining =ulcer 2.Prevents blood clotting 3. kidney dysfunction
NSAIDS block COX 2 by 1. Reducing pain 2.Suppressing inflamation
Created by: amoniffa



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