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Drugs Affecting the Parasympathetic/Sympathetic Nervous System

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Question
Answer
Muscarinic Agonists prototype?   Bethanechol  
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Bethanechol Routes?   Po(will need larger dose) or SQ(has more adr effects)  
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The antidote of Muscarinic Agonist toxicity? Why?   Atropine...it is a Muscarinic Antagonists and will indirectly give the opposite effect of Bethanechol.  
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Muscarinic Antagonists prototype?   Atropine  
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Atropine Routes?   Topical, PO, IV, IM, SQ  
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The antidote of Muscarinic Antagonists toxicity?   Physostigmine...it is an cholinesterase inhibitor, will stop the breakdown of ACh.  
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What two Muscarinic Antagonists drugs will tx OAB?   Tolterodine/Detrol (Get off the toilet) and Oxybutynin/Ditropan (stop the running)  
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Cholinesterase Inhibitors Reversible prototype?   Neostigmine(short neo)  
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Neostigmine Routes?   PO(need larger dose), SQ, IV, IM. note that it cannot cross the BBB  
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What is the antidote for TX Cholinesterase Inhibitors Reversible OD?   Atropine...because it will stop the muscarinic receptor from being excessively stimulated.  
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What are the four treatment steps from irreversible cholinesterase inhibitors?   1.Ventilation 2.Atropine(stimulate muscarinic) 3.Pralidoxime(reverse effects) 4.Diazepam  
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Prototype for Nondepolarizing neuromuscular blockers?   Tubocuraine  
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Tubocuraine Routes?   IV, IM  
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What is the antidote for Atropine OD   Physostigmine  
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What is the prototype for Depolarizing neuromuscular blockers?   Succinylcholine  
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Succinylcholine routes?   IV, IM  
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What enzyme breaks down Succinylcholine?   pseudocholinesterase  
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Cholinesterase inhibitors enhance the effects of Succinylcholine?   cholinesterase inhibitors delay the degradation of succinylcholine  
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Ganglionic Stimulating Agents prototype?   Nicotine  
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Nicotine Effects?   CV, CNS, GI, and Dependence  
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Ganglionic Blocking Agents prototype?   Mecamylamine  
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Catecholamines Drugs?   Epinephrine, Norepinephrine, Dopamine, Dobutamine and Isoproterenol  
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Noncatecholamine Drugs?   Ephdrine, Phenylephrine and terbutaline  
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Catecholamine Routes?   not PO, must be given by infusion  
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Adrenergic Agonist Prototype?   Epinephrine  
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Epinephrine activates which receptors?   Alpha 1-2 and Beta 1-2  
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What Nursing Intervention should be done with Epinephrine given IV?   Monitor IV site for infiltration, could have loss of blood flow and cause necrosis.  
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Epinephrine Routes?   Topical, Injection and Inhalation  
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Norepinephrine activates which receptors?   Alpha 1-2, Beta 1  
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Isoproternol activates which receptors?   Beta 1-2  
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Dopamine activates which receptors?   Alpha 1, Beta 1 and Dopamine, dependent on the dose  
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Dobutamine activates which receptors?   Beta 1  
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Prototype of Selective Alpha Adrenergic Antagonist?   Prazosin, blocks alpha 1 only  
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Prototype of Nonselective Alpha Adrenergic Antagonist?   Phentolamine, blocks alpha 1 and 2  
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Phenoxybenzamine treats?   Phenochromocytoma  
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Prototype of Nonselective Beta Adrenergic Antagonist?   Propranolol, blocks beta 1 and beta 2  
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Prototype of Selective Beta Adrenergic Antagonist?   Metoprolol  
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Drug interactions with Propranolol   Calcium Channel Blockers, can mask hypoglycemia  
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Types of Adrenergic neuron blocking agents?   Respirine and Guanethidine  
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Respirine treats?   hypertension, schizophrenia and psychotic patients.  
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Guanethidine treats?   hypertension only  
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Centrally acting alpha 2 agonist types?   Clondine and Methyldopa  
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Clondine treats?   hypertension and pain for cancer patients  
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Methyldopa treats?   Hypertension  
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