Antipsoriatic drugs
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| Tazarotene | (most common)
receptor-selectted retinoid
-normalize epidermal differentiation, reduce the influx of inflammatory cells into the skin
*Tx of plaque psoriasis & mild-severe facial acne
*preg X cat. :(
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| Tar-Containing products | 1st meds used to treat psoriasis
-antiseptic, antibacterial, antiseborrheic property & works to soften and loosen scally of crusted areas of the skin.
A/E: skin burning, photosensitivity, irritations
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| anthralin | -Inhibits DNA synthese & mitosis w/i the epidermis to reduce psoriatic lesions
-preg C category
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| Calcipotriene | synthetic Vit D3 analogue, works by binding to Vit B3 receptors in skin cells
- helps to regulate the growth & reproduction of keratinocytes
A/E: skin irritation, worsening psoriasis, skin atrophy, folliculitis
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| Etanercept | Decrease progression S&S's of rheumatoid arthritis
-binds to tumor necrosis, making it inactive
-60% absorbed after subcute injection
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| Alefacept | given IM
-used to Tx mod-severe chronic plaque psoriasis
-Immunosuppressant(works by stopping the action of certain cells in the body)
A/E: dizziness, pain, redness, swelling, and bleeding where meds were injected
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| Ustekinumab (Stelara) | *newest (given subcute)
injectable for plaque psoriasis
pt must receive FDA approval
A/E: increased risk for infection
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