From ANCC Review
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Cholinesterase inhibitors | cognex, aricept, razadyne, exelon
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| initiation of cholinesterase inhibitor | start low and go slow
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| anticipate this with this population | greater sensitivity to medication side effects
be alert to impact on general medical conditions
employ polypharm with care
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| initiate medication based on | severity of symptoms
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| When do you treat psychosis and agitation pharmacologically | when behavior is dangerous or upsetting
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| should treat this with dementia | depression
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| this should be given to help cognitive faculties in addition | Vitamin E at 2000IU/day
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| NPs should educate these individuals | caregivers as well
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| stabilization and maintenance of dementia | alzheimer dementia is progressive so needs will continually need to be reassessed
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| if pt is experiencing GI problem, there is less of one with this medication | patch
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| for mild to moderate alzheimers give this | cholinesterase inhibitor
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| a cholinesterase inhibitor works by | making more ACh available.
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| a cholinesterase inhibitor treats these issue | behavioral, psychological and cognitive symptoms
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| adverse effects of cholinesterase inhibitors | N/V/D appetite loss and increased gastric acid secretion
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| donepezil (Aricept) dosage | 5-10mg HS with slow titration
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| First line treatment for dementia | Aricept
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| Aricept does this | increase LFTs
less GI upset
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| tacrine (Cognex) dosage | 40-160mg/day
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| tacrine (Cognex) monitoring | monitor LFTs
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| tacrine (Cognex) is not the first line anymore because | hepatotoxic
many drug interactions
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| galantamine (Razadyne ) dosing | 16-24mg/day
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| rivastigmine (Exelon) | 6-12mg in two doses orally
9.5mg/24 hrs for the patch
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| treat agitation associated with dementia with these drugs | SSRIs
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| for severe alzheimers use | NMDA glutamate receptor antagonist
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| An NMDA glutamate receptor antagonist example | Namenda
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| Namenda works by | blocking low level overexcitation of glutamate receptors and stabilizes neurodegenerative process
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| Namenda is nice because | it is well tolerated and low incidence of adverse effects.
it promotes synaptic plasticity
can be used in combination with cholinesterase inhibitors
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| memantine (Namenda) dosage | 10mg BID
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jonquil
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