pathophysiology exam one material
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show | Pathophysiology
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show | Etiology
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The "sequence of cellular and tissue events that take place from the time of initial contact with the etiologic agents until the ultimate expression of a disease" (origin) | show 🗑
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show | morphological changes
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"describes the effects an illness has on a person's life" | show 🗑
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show | Mortality
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Smoking is responsible for approximately ____% of all deaths in the US | show 🗑
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High blood pressure is responsible for _____% deaths in adults | show 🗑
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show | 17
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show | 45
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High blood pressure (hypertension) kills ____x as many women as breast cancer | show 🗑
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show | 70
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show | 3
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BMI 25.0 to 29.99 ___% more likely to die during study | show 🗑
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BMI 30.0 to 34.99 (grade 1 obesity) _____% more likely to die during study | show 🗑
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BMI 35.0 to 39.99 (grade 2 obesity) _____% more likely to die during study | show 🗑
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BMI > 40 (grade 3 obesity; morbid obesity) more likely to die ___% | show 🗑
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show | 18
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_____ signaling relies on hormones carried in the bloodstream to cells throughout the body | show 🗑
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show | paracrine
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______signaling occurs when a cell releases a chemical into the extracellular fluid that affects its own activity (self-stimulatiing) | show 🗑
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show | synaptic
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Movement of water across membrane- from an area of lesser concentration to area of greater concentration | show 🗑
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gas and other substances move- from an area of greater concentration to an area of lesser concentration | show 🗑
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show | Facilitated Diffusion
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show | Active transport
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show | resting membrane potential
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show | threshold potential
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show | depolarization
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polarity of resting potential is reestablished | show 🗑
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______ is avascular, supported by basement membrane; for covering | show 🗑
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_____: decrease in size of body bart (cell, tissues, organs) 1. due to disease, denervation, lack of endocrine stimulation, decreased nutrition, ischemia (reversible) | show 🗑
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show | Hypertrophy
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Increased in number of cells | show 🗑
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show | metaplasia
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show | dysplasia
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DNA to RNA | show 🗑
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RNA to protein | show 🗑
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show | messenger
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show | Ribosomal
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show | transfer
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genetic information stored in the base sequence triplet code | show 🗑
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"expression of the gene"- recognizable traits physical, or biochemical associated with specific genotype | show 🗑
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____ refers to the manner in which the gene is expressed in the phenotype, which can range from mild to severe | show 🗑
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____ represents the ability of a gene to express its function (statistics in population of how many people express that gene) | show 🗑
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show | homozygotes
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have different alleles at gene locus | show 🗑
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_____ trait is one expressed only in a homozygous pairing (hides itself) | show 🗑
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show | Dominant
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____ is a person who is herozygous for a recessive trait and does not manifest the trait | show 🗑
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Alternate forms of a gene at gene locus | show 🗑
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Genetic? | show 🗑
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show | congenital and Birth Defect
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50% chance of transmitting disorder | show 🗑
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show | familial hypercholesterolemia
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show | Cystic fibrosis
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#1 ARN among African Americans? | show 🗑
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show | G6PD dificiency
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Most common chromosome disorder? | show 🗑
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show | 15-60 days (8weeks)
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what is the product of altered cell growth? usually are classified as benign or malignant? | show 🗑
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neoplasm that contain well-differentiated cells that are clustered together in a single mass | show 🗑
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_____. are less well differentiated and have the ability to break loose, enter the circulatory or lymphatic system and form secondary ____ tumors at other sites | show 🗑
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_____cells are essential or functional elements of an organ (distinguished from stroma or framework) | show 🗑
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show | Papilloma
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growth protruding from mucous membrane (common in uterus) usually benign | show 🗑
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Something that procedes (oncogenic) | show 🗑
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the study of tumors (sum of knowledge) | show 🗑
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production or causation of tumors | show 🗑
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show | anaplasia
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show | doubling time
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describe the development of a secondary tumor in a location distant from the primary tumor | show 🗑
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show | paraneoplastic syndrome
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show | grading
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show | staging
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show | stressor
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show | Heat cramps
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heat _____ increased body temperatures leading to hypothalamic responses of vasodilation and increased perspiration | show 🗑
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show | stroke
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As core temperature exceeds _____degrees neuroendocrine control becomes lost as tissue damage occurs (damage to hypothalamus) | show 🗑
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show | 105.8
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death (neural death) with brain temperature over _____ | show 🗑
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show | Hypothermia
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show | Mild
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_______ hypothermia < 32.2'C down to 28'C (90-82.5'F) SX: atrial dysrhythmias, decreased HR, RR, LOC, pupils dilate, hyporeflexia | show 🗑
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______ hypothermia <28'C (<82.4) SX: apnea, coma, decreased to absent HR, nonreactive pupils, oliguria, pulmonary edema, dysrhythmias, death at something below 50'F | show 🗑
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diseases that produce body dysfunction because of the presence of another living agent in or on the human body | show 🗑
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show | Commensalism
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Some relationships are actually beneficial to both the host and parasite - bacteria in GI tract make vitamin K | show 🗑
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Infecting organism causes damage to the host-pathogens | show 🗑
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show | carrier state
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show | Opportunistic pathogenicity
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period of pathogenesis (how long until virus becomes symptomatic) | show 🗑
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show | predromal stage
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show | acute stage
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show | convalescent stage
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show | Resolution
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show | cadherins
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show | Selectins
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show | Integrins
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show | Immunoglobulin Seperfamily of proteins
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Cell death in an organ or tissue that is still part of a living organisms | show 🗑
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show | liquefaction
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show | coagulation
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show | caseous
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show | gangrene
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___ gangrene: arterial insufficiency- skin wrinkles-black-brown color, line of demarcation-never gets infected | show 🗑
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___ gangrene: cold, swollen, pulseless skin, moist, black and under tension (no line of demarcation- often gets infected- results from interference with venous return from part | show 🗑
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show | Gene expression
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show | induction
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show | G1 phase
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Dna synthesis and replication of chromosomes | show 🗑
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show | G2 phase
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Formation of meiotic spindle and cell division with formation of two daughter cells | show 🗑
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show | intermittent
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show | remittent
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_____fever: tempe remains above normal with minimal variations | show 🗑
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____fever: one or more episodes of fever (each as long as several days) with one or more days with normal temperature in between | show 🗑
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show | 100.4
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elderly often have a lower baseline temperature- so a slight fever can indicate bad infection | show 🗑
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show | anorexia, myalgia, arthralgia, fatigue
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-rapid- serves as a protective mechanism- occurs more in deconditioned muscles (bed rest) | show 🗑
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Possible causes of chronic fatigue: | show 🗑
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Cardiac response to bed rest: | show 🗑
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show | atelactasis, hypoxemia, and pneumonia
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Urinary tract response: | show 🗑
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acquired from hosts own microbial flora, as in an opportunistic infections | show 🗑
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show | exogenous
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inanimate objects that carry an infectious agent | show 🗑
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show | congenital infections
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passed from animals to humans | show 🗑
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develop while in hospital | show 🗑
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acquired outside of health care facilities | show 🗑
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show | symptomatology
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Do not contain proteins, not actively released from bacteria, composed of lipids, and polysaccharides, no enzymatic activity | show 🗑
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contain proteins released from bacterial cell during growth; enzymatically inactive or modify key cellular constituents leading to cell death and dysfunction | show 🗑
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site to which microorganisms adhere | show 🗑
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show | ligands or adhesions
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ligands that bind to specific carbohydrates | show 🗑
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encodes for many of the components of the complement system and play an important role in the innate immunity process | show 🗑
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show | HLA
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early (almost immediate) reaction of local tissues and their blood vessels to injury | show 🗑
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show | chemotaxis
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produce anti platelet and antithrombotic agents that maintain vessels latency and vasodilators and vasoconstrictors that regulate blood flow | show 🗑
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cell fragments circulating in the blood that are involved in the cellular mechanisms of primary hemostasis | show 🗑
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show | neutrophils
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show | eosinophils
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contain histamine and other mediators of inflammation, bind IgE by plasma cells through receptors on there cells surface | show 🗑
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contain functioning cells of an organ or body part | show 🗑
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consists of supporting connective tissue, blood volume, ECM and nerve fibers | show 🗑
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show | labile cells
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show | stable cells
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cannot undergo mitotic division- fibrous scar | show 🗑
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begins at time of injury with formation of blood clot and the migration of phagocytic WBC into wound site: first cello to arrive are neutrophils then macrophages | show 🗑
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focus on the building of new tissue to fill wound space, key cells is fibroblast which secrete collagen and other things needed for wound healing; also produce growth factors which initiate angiogensis (growth of new blood vessel) | show 🗑
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occurs 3 weeks, after injury with development of a fibrous scar, decreased vascularity and continuous remodeling of scar tissue by simultaneous synthesis of collage by fibroblast and lysis increased tensile strength | show 🗑
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_______ reactions have IgE mediated reactions that develop rapidly upon exposure to an antigen, represents the classic allergic response: antigens are referred to as allergens in this context | show 🗑
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show | Oligodendrocytes
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show | astrocytes
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show | microglial
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ependymal cell- forms the lining of neural tube cavity | show 🗑
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show | satellite cells
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show | schwann cells
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show | first
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____ order neurons; communicate with various networks (directly to thalamus) | show 🗑
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show | third
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show | histamine, prostaglandins, bradykinins
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show | neutrophils, macrophages, and lysosomal enzymes
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Infl. mediators of chemotaxis, WBC attracted to bacteria | show 🗑
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Infla. mediators for pain: | show 🗑
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inflammation mediators of fever: | show 🗑
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inflammation mediators of leukocytosis: | show 🗑
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_____exudate: water, low in protein | show 🗑
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show | fibrinous
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show | membranous
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____exudate: contains pus, abscess vs. cellulitis | show 🗑
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____ exudate: blood | show 🗑
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____exudate: combination of serous and blood | show 🗑
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show | vasodilation
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show | swelling
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show | tissue swelling and release of chemical mediators
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Cellular response: ____ ready to leave vascular system | show 🗑
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Cellular response:______ into tissue spaces | show 🗑
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Cellular response:______ positive (attracts WBC) or negative (repel WBC) | show 🗑
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show | phagocytosis
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Type __ allergic response: IgE mediated, allergic conditions that usually have familial predisposition | show 🗑
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show | 2
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show | III
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show | IV
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