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pathophysiology exam one material

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
show Pathophysiology  
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show Etiology  
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The "sequence of cellular and tissue events that take place from the time of initial contact with the etiologic agents until the ultimate expression of a disease" (origin)   show
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show morphological changes  
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"describes the effects an illness has on a person's life"   show
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show Mortality  
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Smoking is responsible for approximately ____% of all deaths in the US   show
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High blood pressure is responsible for _____% deaths in adults   show
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show 17  
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show 45  
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High blood pressure (hypertension) kills ____x as many women as breast cancer   show
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show 70  
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show 3  
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BMI 25.0 to 29.99 ___% more likely to die during study   show
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BMI 30.0 to 34.99 (grade 1 obesity) _____% more likely to die during study   show
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BMI 35.0 to 39.99 (grade 2 obesity) _____% more likely to die during study   show
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BMI > 40 (grade 3 obesity; morbid obesity) more likely to die ___%   show
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show 18  
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_____ signaling relies on hormones carried in the bloodstream to cells throughout the body   show
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show paracrine  
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______signaling occurs when a cell releases a chemical into the extracellular fluid that affects its own activity (self-stimulatiing)   show
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show synaptic  
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Movement of water across membrane- from an area of lesser concentration to area of greater concentration   show
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gas and other substances move- from an area of greater concentration to an area of lesser concentration   show
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show Facilitated Diffusion  
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show Active transport  
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show resting membrane potential  
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show threshold potential  
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show depolarization  
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polarity of resting potential is reestablished   show
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______ is avascular, supported by basement membrane; for covering   show
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_____: decrease in size of body bart (cell, tissues, organs) 1. due to disease, denervation, lack of endocrine stimulation, decreased nutrition, ischemia (reversible)   show
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show Hypertrophy  
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Increased in number of cells   show
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show metaplasia  
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show dysplasia  
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DNA to RNA   show
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RNA to protein   show
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show messenger  
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show Ribosomal  
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show transfer  
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genetic information stored in the base sequence triplet code   show
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"expression of the gene"- recognizable traits physical, or biochemical associated with specific genotype   show
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____ refers to the manner in which the gene is expressed in the phenotype, which can range from mild to severe   show
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____ represents the ability of a gene to express its function (statistics in population of how many people express that gene)   show
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show homozygotes  
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have different alleles at gene locus   show
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_____ trait is one expressed only in a homozygous pairing (hides itself)   show
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show Dominant  
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____ is a person who is herozygous for a recessive trait and does not manifest the trait   show
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Alternate forms of a gene at gene locus   show
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Genetic?   show
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show congenital and Birth Defect  
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50% chance of transmitting disorder   show
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show familial hypercholesterolemia  
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show Cystic fibrosis  
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#1 ARN among African Americans?   show
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show G6PD dificiency  
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Most common chromosome disorder?   show
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show 15-60 days (8weeks)  
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what is the product of altered cell growth? usually are classified as benign or malignant?   show
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neoplasm that contain well-differentiated cells that are clustered together in a single mass   show
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_____. are less well differentiated and have the ability to break loose, enter the circulatory or lymphatic system and form secondary ____ tumors at other sites   show
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_____cells are essential or functional elements of an organ (distinguished from stroma or framework)   show
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show Papilloma  
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growth protruding from mucous membrane (common in uterus) usually benign   show
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Something that procedes (oncogenic)   show
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the study of tumors (sum of knowledge)   show
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production or causation of tumors   show
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show anaplasia  
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show doubling time  
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describe the development of a secondary tumor in a location distant from the primary tumor   show
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show paraneoplastic syndrome  
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show grading  
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show staging  
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show stressor  
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show Heat cramps  
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heat _____ increased body temperatures leading to hypothalamic responses of vasodilation and increased perspiration   show
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show stroke  
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As core temperature exceeds _____degrees neuroendocrine control becomes lost as tissue damage occurs (damage to hypothalamus)   show
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show 105.8  
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death (neural death) with brain temperature over _____   show
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show Hypothermia  
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show Mild  
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_______ hypothermia < 32.2'C down to 28'C (90-82.5'F) SX: atrial dysrhythmias, decreased HR, RR, LOC, pupils dilate, hyporeflexia   show
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______ hypothermia <28'C (<82.4) SX: apnea, coma, decreased to absent HR, nonreactive pupils, oliguria, pulmonary edema, dysrhythmias, death at something below 50'F   show
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diseases that produce body dysfunction because of the presence of another living agent in or on the human body   show
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show Commensalism  
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Some relationships are actually beneficial to both the host and parasite - bacteria in GI tract make vitamin K   show
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Infecting organism causes damage to the host-pathogens   show
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show carrier state  
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show Opportunistic pathogenicity  
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period of pathogenesis (how long until virus becomes symptomatic)   show
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show predromal stage  
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show acute stage  
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show convalescent stage  
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show Resolution  
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show cadherins  
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show Selectins  
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show Integrins  
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show Immunoglobulin Seperfamily of proteins  
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Cell death in an organ or tissue that is still part of a living organisms   show
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show liquefaction  
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show coagulation  
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show caseous  
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show gangrene  
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___ gangrene: arterial insufficiency- skin wrinkles-black-brown color, line of demarcation-never gets infected   show
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___ gangrene: cold, swollen, pulseless skin, moist, black and under tension (no line of demarcation- often gets infected- results from interference with venous return from part   show
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show Gene expression  
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show induction  
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show G1 phase  
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Dna synthesis and replication of chromosomes   show
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show G2 phase  
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Formation of meiotic spindle and cell division with formation of two daughter cells   show
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show intermittent  
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show remittent  
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_____fever: tempe remains above normal with minimal variations   show
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____fever: one or more episodes of fever (each as long as several days) with one or more days with normal temperature in between   show
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show 100.4  
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elderly often have a lower baseline temperature- so a slight fever can indicate bad infection   show
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show anorexia, myalgia, arthralgia, fatigue  
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-rapid- serves as a protective mechanism- occurs more in deconditioned muscles (bed rest)   show
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Possible causes of chronic fatigue:   show
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Cardiac response to bed rest:   show
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show atelactasis, hypoxemia, and pneumonia  
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Urinary tract response:   show
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acquired from hosts own microbial flora, as in an opportunistic infections   show
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show exogenous  
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inanimate objects that carry an infectious agent   show
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show congenital infections  
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passed from animals to humans   show
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develop while in hospital   show
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acquired outside of health care facilities   show
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show symptomatology  
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Do not contain proteins, not actively released from bacteria, composed of lipids, and polysaccharides, no enzymatic activity   show
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contain proteins released from bacterial cell during growth; enzymatically inactive or modify key cellular constituents leading to cell death and dysfunction   show
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site to which microorganisms adhere   show
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show ligands or adhesions  
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ligands that bind to specific carbohydrates   show
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encodes for many of the components of the complement system and play an important role in the innate immunity process   show
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show HLA  
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early (almost immediate) reaction of local tissues and their blood vessels to injury   show
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show chemotaxis  
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produce anti platelet and antithrombotic agents that maintain vessels latency and vasodilators and vasoconstrictors that regulate blood flow   show
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cell fragments circulating in the blood that are involved in the cellular mechanisms of primary hemostasis   show
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show neutrophils  
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show eosinophils  
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contain histamine and other mediators of inflammation, bind IgE by plasma cells through receptors on there cells surface   show
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contain functioning cells of an organ or body part   show
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consists of supporting connective tissue, blood volume, ECM and nerve fibers   show
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show labile cells  
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show stable cells  
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cannot undergo mitotic division- fibrous scar   show
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begins at time of injury with formation of blood clot and the migration of phagocytic WBC into wound site: first cello to arrive are neutrophils then macrophages   show
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focus on the building of new tissue to fill wound space, key cells is fibroblast which secrete collagen and other things needed for wound healing; also produce growth factors which initiate angiogensis (growth of new blood vessel)   show
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occurs 3 weeks, after injury with development of a fibrous scar, decreased vascularity and continuous remodeling of scar tissue by simultaneous synthesis of collage by fibroblast and lysis increased tensile strength   show
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_______ reactions have IgE mediated reactions that develop rapidly upon exposure to an antigen, represents the classic allergic response: antigens are referred to as allergens in this context   show
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show Oligodendrocytes  
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show astrocytes  
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show microglial  
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ependymal cell- forms the lining of neural tube cavity   show
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show satellite cells  
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show schwann cells  
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show first  
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____ order neurons; communicate with various networks (directly to thalamus)   show
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show third  
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show histamine, prostaglandins, bradykinins  
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show neutrophils, macrophages, and lysosomal enzymes  
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Infl. mediators of chemotaxis, WBC attracted to bacteria   show
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Infla. mediators for pain:   show
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inflammation mediators of fever:   show
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inflammation mediators of leukocytosis:   show
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_____exudate: water, low in protein   show
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show fibrinous  
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show membranous  
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____exudate: contains pus, abscess vs. cellulitis   show
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____ exudate: blood   show
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____exudate: combination of serous and blood   show
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show vasodilation  
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show swelling  
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show tissue swelling and release of chemical mediators  
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Cellular response: ____ ready to leave vascular system   show
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Cellular response:______ into tissue spaces   show
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Cellular response:______ positive (attracts WBC) or negative (repel WBC)   show
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show phagocytosis  
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Type __ allergic response: IgE mediated, allergic conditions that usually have familial predisposition   show
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show 2  
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show III  
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show IV  
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