Top 200 #6
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| NSAID, Analgesic, Oxicam | Mobic | Meloxicam | Juvenile RA, osteoarthritis, RA | Oral Susp: 7.5mg/5ml Oral Tablet: 7.5 or 15 mg | Oral | 7.5mg QD Max: 15mg QD | Juvenile RA: 2YO+: 0.125mg/kg QD, Max: 7.5mg/day (dose should be individualized based on weight) | Action may be related to prostaglandin synthetase (COX) inhibition
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| NSAID, Analgesic, Propionic Acid | Motrin | Ibuprofen | Fever, HA, migraine, osteoarthritis, pain, primary dysmenorrhea, RA | Capsule: 200mg Oral Susp: 100mg/5ml, 50mg/1.25ml, 40mg/ml; Oral Tablet: 100, 200, 400, 600, 800mg; IV Soln: 100mg/ml Chewable Tablet: 100mg | Oral, IV | Varies 200-800mg q6h | Varies 6mo+: 10mg/kg q6h | Exhibits analgesic & antipyretic activities by inhibiting prostaglandin synthesis
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| NSAID, Analgesic, Propionic Acid | Naprosyn; Anaprox | Naproxen | Ankylosing spondylitis, bursitis, gout (acute), osteoarthritis, pain, primary dysmenorrhea, RA, tendinitis (acute) | Oral Susp: 125mg/5ml Oral Tablet: 250, 375, 500mg Enteric Coated Tablet (DR): 375, 500mg | Oral | Varies Max= 1500 mg/day | 2YO+: Indicated for RA: 15mg/kg/day | MOA is unknown but thought to be related to inhibition of prostaglandin synthetase
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| Aliphatic; Antihistamine; GI Agent; Phenothiazine | Phenergan | Promethazine | Administration of analgesic; allergy; motion sickness; N/V; postoperatice pain (adjunct); sedation | Inj. Soln: 25mg/ml, 50mg/ml Oral Syrup: 6.25mg/5ml; Oral Tablet: 12.5, 25, 50mg; Rectal Suppository: 12.5, 25, 50mg | Oral, IM, IV, Rectal | Varies 12.5-50mg q4-6h | Varies 2YO+: 6.25-25mg q4-6h | Competitively blocks histamine H(1) receptors without blocking the secretion of histamine
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| Skeletal Muscle Relaxant, (Centrally Acting) | Flexeril; Amrix | Cyclobenzaprine | Skeletal muscle spasm | ER Capsule: (amrix) 15 or 30mg Tablet: (flexeril) 5, 7.5, 10mg | Oral | IR Tablets: 5mg TID, may increase to 10mg TID for up to 2 to 3 weeks; ER Capsules: 15mg QD, may increase to 30mg QD for up to 2 to 3 weeks | 15YO+: Adult Dosing | Acts primarily at the brain stem within the CNS as opposed to the spinal cord. It influences both gamma & alpha motor systems by reducing tonic somatic motor activity.
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| Skeletal Muscle Relaxant | Soma | Carisoprodol | Disorder of musculoskeletal system | Oral Tablet: 250, 350mg | Oral | 250-350mg TID & HS | 16YO+: Adult dosing | Blocks interneuronal activity in descending reticular formation and spinal cord, resulting in muscle relaxation
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| Opioid Dependency | Subutex; Suboxone; Butrans | Buprenorphine; Buprenorphine/ Naloxone | Opioid Dependence | SL Tablet: 2mg, 8mg SL Film: (suboxone) 2mg/0.5mg, 4/1, 8/2, 12/3 Trans Patch: (butrans) 5, 7.5, 10, 15, 20mcg/hr | Sub-lingual | Varies | 16YO+: Adult dosing | Mu-opioid receptor partial agonist & kappa-opioid receptor antagonist
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| Analgesic; Opioid | Duragesic | Fentanyl Transderm | Breakthrough cancer pain (in opioid-tolerant pts); chronic pain | 12, 25, 50, 75, or 100 mcg/hr | Topical/Transderm | Varies | Varies 2YO+ | Works primarily with opioid mu-receptors in the CNS
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| Analgesic; Opioid | Oxycontin; Roxicodone | Oxycodone | Chronic pain (moderate to severe) | Oral Capsule: 5mg Oral Soln: 5mg/5ml, 20mg/ml Oral Tablet: 5, 10, 15, 20, 30mg ER Tablet: 10, 15, 20, 30, 40, 60, 80mg | Oral | Varies | N/A | Pure opioid agonist relatively selective for the mu receptor.
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| Analgesic; Opioid | Ultram; Ultram ER; Ryzolt; Rybix | Tramadol | Chronic pain (moderate to moderately-severe) | ER Capsule: 150mg Tablet: 50mg ER Tablet: 100, 200, 300mg; Oral Susp: 10mg/ml | Oral | Varies | 16YO+ ER tabs not for <18YO | Centrally-acting synthetic opioid analgesic that exerts its effects through the mu-receptor
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| Opioid/ Acetaminophen Combo | Tylenol W/ Codeine | Acetaminophen/ Codeine | Pain (mild to moderately severe) | Oral Elixir/Soln: 120mg-12mg/5ml; Oral Tablet: 300/15, 300/30, 300/60mg | Oral | Tablets: 300-1000mg APAP/15-60mg Codeine Q4hrs PRN (max 4000mg APAP/360mg Codeine daily) Soln/Susp: 15ml (360mg APAP/36mg Codeine) Q4 hrs PRN | 3YO+: 3-6 YO: 5ml (120mg APAP/12mg Codeine) 3-4 times daily; 7-12 YO: 10ml (240mg APAP/24mg Codeine) 3-4 times daily; 12 YO+: 15ml (360mg APAP/36mg Codeine) QID PRN | Combo of peripherally acting analgesic (APAP) and a centrally acting analgesic (codeine)
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| Opioid/ Acetaminophen Combo | Vicodin; Lortab; Lorcet; Norco; Zydone | Hydrocodone/ APAP | Hydrocodone/ APAP | Oral Elixir/Soln: Many strengths Oral Tablet: 5mg/300mg, 7.5/300, 10/300, 2.5/300, 5/325, 7.5/325, 10/325 | Oral | Varies | Varies 2YO+ | APAP works on the hypothalamic heat regulating center as well as inhibits prostaglandin synthesis;
Hydrocodone is an opioid analgesic & antitussive with unknown MOA but thought to be related to the presence of opiate receptors in the CNS
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| Opioid/ Acetaminophen Combo | Percocet | Oxycodone/APAP | Pain (moderate to moderate-severe) | Tablet: 2.5/325, 5/325, 7.5/325, 10mg/325mg | Oral | Varies | N/A | Oxycodone is a semisynthetic pure opioid agonist; APAP is an analgesic/antipyretic
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| NSAID; Analgesic; COX-2 Inhibitor | Celebrex | Celecoxib | Ankylosing spondylitis, juveniles RA, osteoarthritis, pain (acute), primary dysmenorrhea, RA | Capsule: 50, 100, 200, 400mg | Oral | Typically 100-200mg BID; loading dose of 400mg if needed in certain indications | 2YO+ Juvenile RA: 10-25 kg = 50mg BID; >25 kg= 100mg BID | NSAID that selectively inhibits COX-2 enzyme activity
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| Adrenal Glucocorticoid; Endocrine-Metabolic Agent | Deltasone | Prednisone | Adrenal insufficiency; Allergic disorder (severe); asthma; cerebral edema; disorders of eye, GI tract, endocrine system, respiratory system, skin; exacerbation of MS, Hodgkin’s disease, inflamm disorder of musculoskeletal system | Oral soln: 5mg/mL; Tablet: 1, 2.5, 5, 10, 20, 50mg | Oral | Varies | Varies 0-11YO: 1-2mg/kg/day 12YO+: Adult dosing | Adrenocorticol steroid with salt-retaining properties; causes anti-inflammatory effects in diff disorders of many organ systems
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| Butalbital/ Acetaminophen Combo | Fioricet; Esgic | Butalbital/APAP/ Caffeine | HA, complex tension or muscle contraction | Capsule:(fioricet) 50/300/40 or 50/325/40 mg; Tablet:(esgic) 50/325/40 | Oral | 1-2 tablets Q4 hrs (max of 6 doses/day) | 12YO+: Adult dosing | Non-opiate, non-salicylate analgesic & antipyretic. Butalbital is a short to intermediate-acting barbiturate, while caffeine is a CNS stimulant
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| Amino Amide; Anesthetic (local) | Lidoderm | Lidocaine | Local Anesthesia, postherpetic neuralgia | 5% ER Topical Patch | Topical | Apply up to 3 patches for up to 12 hours within a 24-hr period (12 HRS on, 12 HRS off) | N/A | Blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to Na+ ions, which results in inhibition of depolarization with resultant blockade of conduction
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| Analgesics; Gamma aminobutyric acid; neuropathic pain agent (Anticonvulsant) | Lyrica | Pregabalin | Diabetic neuropathy, fibromyalgia, neuropathic pain, partial seizures, spinal cord injury | Oral Soln: 20mg/mL Capsule: 25, 50, 75, 100, 150, 200, 225, 300 mg | Oral | Varies Max: 450mg/day | N/A | GABA (gamma-aminobutyric acid) analog that strongly binds to the α2-delta site in CNS tissues
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| Anticonvulsant; Gamma Aminobutyric Acid | Neurontin; Horizant; Gralise | Gabapentin | Partial seizure (adjunct); postherpetic neuralgia | Horizant ER Tabs: 300, 600mg Neurontin Tab: 600, 800mg Neurontin Cap: 100, 300, 400mg Neurontin Soln: 250mg/5ml Gralise Tabs: 300, 600mg | Oral | Varies 300-1800mg/day | Varies Partial Seizure: 3-11YO: 10-15 mg/kg/day in 3 div doses 12YO+: Adult dosing Gralise: N/A | Does not bind to GABA-a or GABA-b receptors, but MOA is unknown
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| Adrenal Glucocorticoid; Endocrine-Metabolic Agent | Medrol | Methylprednisolone | Allergic disorder; asthma; collagen, crohn’s, neoplastic disease; disorder of endocrine system, eye, hematopoietic structure, respiratory system, skin; exacerbation of MS, hypercalcemia of malignancy, inflamm disorder of musculoskeletal system; | Oral tablet: 2, 4, 8, 16, 32mg | Oral | Varies 4-48mg per day | Varies 4-48mg per day | Synthetic glucocorticoid, has potent anti-inflammatory activity in disorders of many organ systems and has Na+ retaining properties
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