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Top 200 #6

ClassBrandGenericIndicationsDose FormsRouteAdult DosePed. DoseMOA
NSAID, Analgesic, Oxicam Mobic Meloxicam Juvenile RA, osteoarthritis, RA Oral Susp: 7.5mg/5ml Oral Tablet: 7.5 or 15 mg Oral 7.5mg QD Max: 15mg QD Juvenile RA: 2YO+: 0.125mg/kg QD, Max: 7.5mg/day (dose should be individualized based on weight) Action may be related to prostaglandin synthetase (COX) inhibition
NSAID, Analgesic, Propionic Acid Motrin Ibuprofen Fever, HA, migraine, osteoarthritis, pain, primary dysmenorrhea, RA Capsule: 200mg Oral Susp: 100mg/5ml, 50mg/1.25ml, 40mg/ml; Oral Tablet: 100, 200, 400, 600, 800mg; IV Soln: 100mg/ml Chewable Tablet: 100mg Oral, IV Varies 200-800mg q6h Varies 6mo+: 10mg/kg q6h Exhibits analgesic & antipyretic activities by inhibiting prostaglandin synthesis
NSAID, Analgesic, Propionic Acid Naprosyn; Anaprox Naproxen Ankylosing spondylitis, bursitis, gout (acute), osteoarthritis, pain, primary dysmenorrhea, RA, tendinitis (acute) Oral Susp: 125mg/5ml Oral Tablet: 250, 375, 500mg Enteric Coated Tablet (DR): 375, 500mg Oral Varies Max= 1500 mg/day 2YO+: Indicated for RA: 15mg/kg/day MOA is unknown but thought to be related to inhibition of prostaglandin synthetase
Aliphatic; Antihistamine; GI Agent; Phenothiazine Phenergan Promethazine Administration of analgesic; allergy; motion sickness; N/V; postoperatice pain (adjunct); sedation Inj. Soln: 25mg/ml, 50mg/ml Oral Syrup: 6.25mg/5ml; Oral Tablet: 12.5, 25, 50mg; Rectal Suppository: 12.5, 25, 50mg Oral, IM, IV, Rectal Varies 12.5-50mg q4-6h Varies 2YO+: 6.25-25mg q4-6h Competitively blocks histamine H(1) receptors without blocking the secretion of histamine
Skeletal Muscle Relaxant, (Centrally Acting) Flexeril; Amrix Cyclobenzaprine Skeletal muscle spasm ER Capsule: (amrix) 15 or 30mg Tablet: (flexeril) 5, 7.5, 10mg Oral IR Tablets: 5mg TID, may increase to 10mg TID for up to 2 to 3 weeks; ER Capsules: 15mg QD, may increase to 30mg QD for up to 2 to 3 weeks 15YO+: Adult Dosing Acts primarily at the brain stem within the CNS as opposed to the spinal cord. It influences both gamma & alpha motor systems by reducing tonic somatic motor activity.
Skeletal Muscle Relaxant Soma Carisoprodol Disorder of musculoskeletal system Oral Tablet: 250, 350mg Oral 250-350mg TID & HS 16YO+: Adult dosing Blocks interneuronal activity in descending reticular formation and spinal cord, resulting in muscle relaxation
Opioid Dependency Subutex; Suboxone; Butrans Buprenorphine; Buprenorphine/ Naloxone Opioid Dependence SL Tablet: 2mg, 8mg SL Film: (suboxone) 2mg/0.5mg, 4/1, 8/2, 12/3 Trans Patch: (butrans) 5, 7.5, 10, 15, 20mcg/hr Sub-lingual Varies 16YO+: Adult dosing Mu-opioid receptor partial agonist & kappa-opioid receptor antagonist
Analgesic; Opioid Duragesic Fentanyl Transderm Breakthrough cancer pain (in opioid-tolerant pts); chronic pain 12, 25, 50, 75, or 100 mcg/hr Topical/Transderm Varies Varies 2YO+ Works primarily with opioid mu-receptors in the CNS
Analgesic; Opioid Oxycontin; Roxicodone Oxycodone Chronic pain (moderate to severe) Oral Capsule: 5mg Oral Soln: 5mg/5ml, 20mg/ml Oral Tablet: 5, 10, 15, 20, 30mg ER Tablet: 10, 15, 20, 30, 40, 60, 80mg Oral Varies N/A Pure opioid agonist relatively selective for the mu receptor.
Analgesic; Opioid Ultram; Ultram ER; Ryzolt; Rybix Tramadol Chronic pain (moderate to moderately-severe) ER Capsule: 150mg Tablet: 50mg ER Tablet: 100, 200, 300mg; Oral Susp: 10mg/ml Oral Varies 16YO+ ER tabs not for <18YO Centrally-acting synthetic opioid analgesic that exerts its effects through the mu-receptor
Opioid/ Acetaminophen Combo Tylenol W/ Codeine Acetaminophen/ Codeine Pain (mild to moderately severe) Oral Elixir/Soln: 120mg-12mg/5ml; Oral Tablet: 300/15, 300/30, 300/60mg Oral Tablets: 300-1000mg APAP/15-60mg Codeine Q4hrs PRN (max 4000mg APAP/360mg Codeine daily) Soln/Susp: 15ml (360mg APAP/36mg Codeine) Q4 hrs PRN 3YO+: 3-6 YO: 5ml (120mg APAP/12mg Codeine) 3-4 times daily; 7-12 YO: 10ml (240mg APAP/24mg Codeine) 3-4 times daily; 12 YO+: 15ml (360mg APAP/36mg Codeine) QID PRN Combo of peripherally acting analgesic (APAP) and a centrally acting analgesic (codeine)
Opioid/ Acetaminophen Combo Vicodin; Lortab; Lorcet; Norco; Zydone Hydrocodone/ APAP Hydrocodone/ APAP Oral Elixir/Soln: Many strengths Oral Tablet: 5mg/300mg, 7.5/300, 10/300, 2.5/300, 5/325, 7.5/325, 10/325 Oral Varies Varies 2YO+ APAP works on the hypothalamic heat regulating center as well as inhibits prostaglandin synthesis; Hydrocodone is an opioid analgesic & antitussive with unknown MOA but thought to be related to the presence of opiate receptors in the CNS
Opioid/ Acetaminophen Combo Percocet Oxycodone/APAP Pain (moderate to moderate-severe) Tablet: 2.5/325, 5/325, 7.5/325, 10mg/325mg Oral Varies N/A Oxycodone is a semisynthetic pure opioid agonist; APAP is an analgesic/antipyretic
NSAID; Analgesic; COX-2 Inhibitor Celebrex Celecoxib Ankylosing spondylitis, juveniles RA, osteoarthritis, pain (acute), primary dysmenorrhea, RA Capsule: 50, 100, 200, 400mg Oral Typically 100-200mg BID; loading dose of 400mg if needed in certain indications 2YO+ Juvenile RA: 10-25 kg = 50mg BID; >25 kg= 100mg BID NSAID that selectively inhibits COX-2 enzyme activity
Adrenal Glucocorticoid; Endocrine-Metabolic Agent Deltasone Prednisone Adrenal insufficiency; Allergic disorder (severe); asthma; cerebral edema; disorders of eye, GI tract, endocrine system, respiratory system, skin; exacerbation of MS, Hodgkin’s disease, inflamm disorder of musculoskeletal system Oral soln: 5mg/mL; Tablet: 1, 2.5, 5, 10, 20, 50mg Oral Varies Varies 0-11YO: 1-2mg/kg/day 12YO+: Adult dosing Adrenocorticol steroid with salt-retaining properties; causes anti-inflammatory effects in diff disorders of many organ systems
Butalbital/ Acetaminophen Combo Fioricet; Esgic Butalbital/APAP/ Caffeine HA, complex tension or muscle contraction Capsule:(fioricet) 50/300/40 or 50/325/40 mg; Tablet:(esgic) 50/325/40 Oral 1-2 tablets Q4 hrs (max of 6 doses/day) 12YO+: Adult dosing Non-opiate, non-salicylate analgesic & antipyretic. Butalbital is a short to intermediate-acting barbiturate, while caffeine is a CNS stimulant
Amino Amide; Anesthetic (local) Lidoderm Lidocaine Local Anesthesia, postherpetic neuralgia 5% ER Topical Patch Topical Apply up to 3 patches for up to 12 hours within a 24-hr period (12 HRS on, 12 HRS off) N/A Blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to Na+ ions, which results in inhibition of depolarization with resultant blockade of conduction
Analgesics; Gamma aminobutyric acid; neuropathic pain agent (Anticonvulsant) Lyrica Pregabalin Diabetic neuropathy, fibromyalgia, neuropathic pain, partial seizures, spinal cord injury Oral Soln: 20mg/mL Capsule: 25, 50, 75, 100, 150, 200, 225, 300 mg Oral Varies Max: 450mg/day N/A GABA (gamma-aminobutyric acid) analog that strongly binds to the α2-delta site in CNS tissues
Anticonvulsant; Gamma Aminobutyric Acid Neurontin; Horizant; Gralise Gabapentin Partial seizure (adjunct); postherpetic neuralgia Horizant ER Tabs: 300, 600mg Neurontin Tab: 600, 800mg Neurontin Cap: 100, 300, 400mg Neurontin Soln: 250mg/5ml Gralise Tabs: 300, 600mg Oral Varies 300-1800mg/day Varies Partial Seizure: 3-11YO: 10-15 mg/kg/day in 3 div doses 12YO+: Adult dosing Gralise: N/A Does not bind to GABA-a or GABA-b receptors, but MOA is unknown
Adrenal Glucocorticoid; Endocrine-Metabolic Agent Medrol Methylprednisolone Allergic disorder; asthma; collagen, crohn’s, neoplastic disease; disorder of endocrine system, eye, hematopoietic structure, respiratory system, skin; exacerbation of MS, hypercalcemia of malignancy, inflamm disorder of musculoskeletal system; Oral tablet: 2, 4, 8, 16, 32mg Oral Varies 4-48mg per day Varies 4-48mg per day Synthetic glucocorticoid, has potent anti-inflammatory activity in disorders of many organ systems and has Na+ retaining properties
Created by: scottamus123