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Top 200 #2

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Brand
Generic
Class
Indications
Route/Dose Form
Adult/Ped. Dosing
MOA
Aciphex   Rabeprazole   PPI (proton pump inhibitor)   GERD, Duodenal Ulcer Disease   Oral; Tablet: 20mg   ADULT: 20-60mg QD-BID PED: 1-11YO: 5-10mg QD 12YO+: 20mg QD   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Dexilant   Dexlansoprazole   PPI (proton pump inhibitor)   Esophagitis, GERD, Pyrosis (heartburn)   Oral; Delayed-release capsule: 30 or 60mg   ADULT: 30-60mg QD PED: N/A   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Nexium   Esomeprazole   PPI (proton pump inhibitor)   GERD, Duodenal Ulcer Disease, Gastric Ulcer   Oral, IV; Delayed-release Caps: 20 or 40mg Delayed-release powder for susp: 2.5, 5, 10, 20, 40mg Powder for inj: 20 or 40mg   ADULT: 20-40mg QD PED: 1mo-1YO: 0.5mg/kg QD 1-17YO: 10-20mg QD for 8 wks   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Prevacid   Lansoprazole   PPI (proton pump inhibitor)   Duodenal Ulcer Disease, Gastric Ulcer, Esophagitis, GERD   Oral; Tablets or Solutabs: 15 or 30mg   ADULT: 15-30mg QD PED: 1-17YO: 15-30mg QD   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Prilosec   Omeprazole   PPI (proton pump inhibitor)   GERD, Duodenal Ulcer Disease, Stress Ulcer, Gastric Ulcer, Esophagitis   Oral; Delayed-release granules for susp: 2.5 or 10mg Delayed-release Caps: 10, 20, 40mg Delayed-release OTC Tab: 20mg   ADULT: 20-40mg QD PED 1-16YO: 5-20mg QD   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Protonix   Pantoprazole   PPI (proton pump inhibitor)   GERD, Gastric Hypersecretion   Oral, IV; Delayed-release Tab: 20-40mg Delayed-release granules for susp: 40mg Powder for Inj: 40mg   ADULT: 40-80mg QD-BID PED: 5YO+: 20-40mg QD   Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells  
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Crestor   Rosuvastatin   HMG-CoA Inhibitor   Hyperlipidemia, Hypertriglyceridemia, Atherosclerosis, Hyperlipoproteinemia, Hypercholesterolemia, Prophylaxis   Oral; Tablets: 5, 10, 20, 40mg   ADULT: 5-40mg QD PED: 10-17YO: 5-20mg QD   Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis  
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Lipitor   Atorvastatin   HMG-CoA Inhibitor   Hyperlipidemia, Hypertriglyceridemia, Hypercholesterolemia, Prophylaxis   Oral; Tablets: 10, 20, 40, 80mg   ADULT: 10-80mg QD PED: 10-17YO: 10-20mg QD   Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis  
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Mevacor   Lovastatin   HMG-CoA Inhibitor   Hypercholesterolemia, Prophylaxis, Arteriosclerosis   Oral; Tablets: 10, 20, 40mg   ADULT: 10-80mg QD PED: 10-17YO: 10-40mg QD w/dinner   Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis  
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Pravachol   Pravastatin   HMG-CoA Inhibitor   Hyperlipidemia, Hypercholesterolemia, Prophylaxis   Oral; Tablets: 10, 20, 40, 80mg   ADULT: 40-80mg QD PED: 8-13YO: 20mg QD 13-18YO: 40mg QD   Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis  
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Zocor   Simvastatin   HMG-CoA Inhibitor   Hypercholesterolemia, Hypertriglyceridemia, Prophylaxis   Oral; Tablets: 5, 10, 20, 40mg   ADULT: 5-80mg QD PED: 10-17YO: 10-40mg QD   Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis  
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Vytorin   Ezetimibe/ Simvastatin   COMBO: HMG-CoA Inhibitor & Intestinal Cholesterol Inhibitor   Hyperlipidemia, Hypercholesterolemia   Oral; Tablets: 10/10, 10/20, 10/40, 10/80   ADULT: Ezetimibe (1st strength): 10mg QD Simvastatin (2nd strength): 10-80mg QD PED: N/A   Simvastatin: HMG-CoA Inhibitor Ezetimibe: Intestinal cholesterol inhibitor  
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Zetia   Ezetimibe   Cholesterol Absorption Inhibitor   Hypercholesterolemia, Hyperlipoproteinemia   Oral; Tablet: 10mg   ADULT: 10mg QD PED: 10YO+: 10mg QD   Inhibits absorption of cholesterol at the brush border of the small intestine via the sterol transporter NPC1L1  
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Lovaza   Omega-3 Ethyl Esters   Omega-3 Fatty Acid   Hypertriglyceridemia   Oral; Softgel Capsule: 1g   ADULT: 4g QD (or divided) PED: N/A   Not completely defined  
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Niaspan   Niacin   Nicotinic Acid   Hyperlipidemia   Oral; ER Tablets: 500, 750, 1000mg   ADULT: 100-1000mg TID (max of 4500mg/day) PED: 100-250mg QD (divided into 3 doses)   Precise MOA unknown  
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Pepcid   Famotidine   Histamine H2 Antagonist   Duodenal Ulcer, Dyspepsia, Esophagitis, Gastric Ulcer, GERD, H. Pylori Eradication, Multiple Endocrine Adenoma Syndrome, Pyrosis, Systemic Mastocytosis, Zollinger-Ellison Syndrome   Oral, IV; Tablets: 20 or 40mg; AC 10mg tablet or gelcap Premixed Inj. Soln.: 10mg/ml, 20mg/50ml Powder For Susp: 40mg/5ml Complete Chew Tab   ADULT: 20-160mg QD or BID PED: 0-16YO: 0.5mg/kg QD or BID   Inhibits the binding of histamine to H2 receptors on the gastric basolateral membrane of parietal cells, reducing basal and nocturnal gastric acid secretions  
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Zantac   Ranitidine   Histamine H2 Antagonist   GERD, Duodenal Ulcer Disease, Gastric Ulcer, Indigestion   Oral, IV; Syrup: 75mg/5ml or 150mg/10ml Tablets: 75, 150, 300mg Inj. Soln.: 1mg/ml or 25mg/ml Granules for Soln.: 150mg Effervescent Tab: 25 or 150mg   ADULT: 150-300mg QD or BID IV: 50mg Q6-8hrs PED: 1mo-16YO: 2-4mg/kg/day Oral or IV   Competitive reversible inhibitor of histamine at H2 receptors  
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Tricor; Trilipix; Antara   Fenofibrate   Fibric Acid   Hypercholesterolemia, Hypertriglyceridemia   Oral; Tricor: 48 or 145mg tab; 54 or 160mg micronized tab; 67, 134, 200mg micronized cap Trilipix: 45 or 135 DR cap Antara: 43, 87, or 130mg cap   ADULT: 40-160mg QD PED: N/A   Precise MOA unknown; lipid regulating agent  
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Welchol   Colesevelam   Bile Acid Sequestrant   Hypercholesterolemia, Hyperlipoproteinemia, Type 2 Diabetes Mellitus   Oral; Tablet: 625mg Powder for Susp: 3.75g 1875mg BID or 3750mg QD   ADULT: 3 tabs BID or 6 tabs QD; 1.875 gram packet BID or 3.75 gram packet QD PED: 10-17YO: 3.75 gram packet QD   Binds with bile acids in the intestine to form an insoluble complex that is eliminated in the feces  
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Zofran   Ondansetron   Serotonin Receptor Antagonist, 5-HT3 (Antiemetic)   Chemotherapy, Radiation, Postop induced N/V   Oral, IV, IM; Tablets: 4, 6, 24 mg ODT: 4 or 8mg Inj. Soln.: 2mg/ml or 32mg/50ml in dextrose 5% Oral Soln.: 4mg/5ml   ADULT: 4-8mg up to TID (max 24mg/day) PED: 4-11YO: 4-8mg Q8hrs   Selective 5-HT3 receptor antagonist  
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