step one
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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|---|---|---|---|---|---|
| show | secondary lymph organ
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| function of lymph node | show 🗑
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| show | primary: dense and dormant
secondary: pale central germinal
centers-active
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| show | follicle of cortex
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| show | paracortex
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| describe paracortex region in cell mediated immunity | show 🗑
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| described paracotex in DiGeoges's syndrome? | show 🗑
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| lymph vessel that drain rt. arm and rt. side of head? | show 🗑
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| show | thoracic duct
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| where are T-cells in the spleen? | show 🗑
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| show | within the white pulp
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| what is the Thymus known as? | show 🗑
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| what is tve selection of T-cells? | show 🗑
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| What is -ve selection of T-cells? | show 🗑
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| show | corticmedullary
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| what is clonal anergy? | show 🗑
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| which antigen presenting cell (APC) first react to a foreign antigen? | show 🗑
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| show | macrophages stimulate THo via IL-12 and yet-unidentified stimulate THo via IL-4
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| show | To make a selection; CMI or humoral immunity.
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| To chose CMI, what is the cytokine produced? | show 🗑
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| To chose humoral, what is the cytokine produced? | show 🗑
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| show | Secrete Y-INF and IL-2 to activate macrophage for independent killing.
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| show | Secrete IL-4 and IL-5, IL-2, to stimulate B-cells to plasma cells and lymphocytes
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| show | produce large amounts of antibodies.(ab)
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| how does ab mediated immunity work? | show 🗑
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| what does opsonins do? | show 🗑
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| What is the function does neutralization serve? | show 🗑
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| what is the function of the complement system? | show 🗑
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| show | Via the TH1 arm of the immune pathway, resulting in cellular infiltrates like macrophages and abscess formation.
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| how does ab's mediate an immune attack? | show 🗑
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| show | graft and organ transplantation rejection
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| show | allergies
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| What is major histocompatibility complex (MHC)? | show 🗑
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| show | 2 classes. Class one and class 2
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| What do you know about MHC class I? | show 🗑
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| show | a peptide binding groove between the 2 a heavy chain, serve to present antigen to the TCR of CD8 cells
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| show | RBC
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| what do you know about MHC classII? | show 🗑
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| show | Same as Class one except it presents to the TCR of the CD4 cells.
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| name the types of cells that have both class I andII surface proteins on their cell membrane? | show 🗑
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| Where in MHC classI does antigen loading occur? | show 🗑
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| show | acidified endosome
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| show | associated with TCR of T-lymphocyte and is involved in signal transduction.
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| show | The loaded TCR flags the antigen on the cell membrane awaiting a TCR
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| once CD4's TCR commits and binds with MHC class II of APC, what happens? | show 🗑
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| show | cell mediated killing
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| how does the co-stimulatory molecules of CMI work? | show 🗑
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| show | innate
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| show | CD16 $ CD 56
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| show | CD21 of B-cells
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| show | T-lymphocytes and NK cells
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| How many parts to Ig structure? | show 🗑
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| which portion is embedded in the cell? | show 🗑
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| show | the amino terminal
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| show | region where the Fab and FC region are held together by disulfide bonds
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| show | recognizes antigen
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| show | In the Fab fragment held by dissulfe bonds
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| What is the FC fragment made of? | show 🗑
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| show | Fixes complement
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| what is the function of the hypervariable region of heavy & light chanis? | show 🗑
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| show | IgM because it is a pentamer
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| What is the complement system? | show 🗑
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| show | they serve as zymogens, participating in a cascade of reactions that culminate mediation of inflammation and lysis by MAC complex
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| describe initiation of complement system | show 🗑
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| Describe initiation of the complement pathway | show 🗑
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| show | IgG binds to the Fc region by the hinge region
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| show | for diversity
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| function of random combination of heavy and light chains? | show 🗑
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| show | aka affinity mutation. mutation that occurs after antigenic contact.
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| function of somatic diversity? | show 🗑
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| show | inserts bases withour template at the junction of VDJ segments randomly. All to create more diversity
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| show | Tdt
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| show | IgM and IgD
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| show | switching from IgG to IgA to IgE
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| show | cytokines and CD40L
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| show | plasma cells but does not switch only makes the isotype for which it is cloned.
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| show | IgM
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| Describe IgM | show 🗑
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| show | IgG
🗑
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| Describe IgG | show 🗑
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| how does IgA work to fight infection? | show 🗑
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| function of IgD? | show 🗑
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| functions of IgE | show 🗑
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| show | induces the release of mediators from mast cells, basopils and eosinophils when Ig is stimulated by the exposure to allergens
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| show | immunologic epitope that is different among members of the same species. may be heavy or light chain. Allotype determines compatibility for transplant.
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| define isotype | show 🗑
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| show | Ig epitope, determined by antigen binding site.
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| show | small, single antigenic determinants, unable to mount an immune response independently but can if coupled with another protein.
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| show | meds like asa, streptomycin, sulfa, some opiates, like morphine.
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| show | HOT T-bone sTEAK IL-1 -pyrogen, IL-2 - increased T-cells, IL-3 -increased bone marrow , IL-4 - IgE, IL-5 -IgA.
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| function of IL-1 | show 🗑
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| show | secreted Th cells and stimulates growth of Th and Tc cells.
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| function of IL-3 | show 🗑
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| show | secreted by B-cells, enhances class switching from IgG to IgA, and production and activation of eosinophils.
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| show | major chemotactic stimuli for PMN's
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| function of IL-6 | show 🗑
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| function of IL-10 | show 🗑
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| function of IL-12 | show 🗑
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| function of Y-interferon | show 🗑
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| function of TNF alpha | show 🗑
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| show | CD4, TCR, CD3, CD28, CD40
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| list surface markers of T-cytotoxic cell | show 🗑
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| show | IgD, IgM, B7, CD19, CD20, CD21,CD40L, MHCII
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| show | MHCII, MHCI, CD14, FC, C3b
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| cell surface protein of NK cells | show 🗑
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| cell surface markers for all cells x RBC | show 🗑
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| show | antigenic recognition
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| show | class switching
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| show | signal transduction by TCR
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| function of CD28 | show 🗑
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| show | co-receptor with B21 for signal activation transduction
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| function of CD20 | show 🗑
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| function of CD21 | show 🗑
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| function of C3b | show 🗑
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| Another opsonin | show 🗑
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| show | APC receptor for co-stimulatory molecule B7
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| function of CD14 | show 🗑
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| show | opsonization, ADCC
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| function of CD56 | show 🗑
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| show | creates harsh environment for growth, causes rt. shift of oxy/Hg curve making Hg for O2 making it available for the oxygen burs kill.
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| What is the complement system | show 🗑
|
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| show | 2 pathways: classic and alternate
🗑
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| show | IgG and IgM
🗑
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| how is the alternate pathway initiated? | show 🗑
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| function of the complement system | show 🗑
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| mneumonic for classic pathway | show 🗑
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| show | C1
🗑
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| Where does C1 bind to the Ig to initiate the System? | show 🗑
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| show | opsonization
🗑
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| function of c1, c2, c3, c4 | show 🗑
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| function of c3a, c5a | show 🗑
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| function of c5a | show 🗑
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| function of c5b - 9 | show 🗑
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| show | IgM is a pentamer and can bind x5 more than IgM which is a monomer.
🗑
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| result of C1 esterase deficiency | show 🗑
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| clinical presentation of c1 esterase defeciency | show 🗑
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| clinical presentation of c3 deficiency | show 🗑
|
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| show | Neisseria bacteremia
🗑
|
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| show | regulatory protein of complement.
🗑
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| show | Places all cells in an antiviral state.
🗑
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| what antiviral process does INF induce? | show 🗑
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| show | Increases MHCI and MHCII expression on all cells.
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| how does INF affect NK cells? | show 🗑
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| show | mediates ADCC: ab dependent cell mediated cytotoxicity.
🗑
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| show | artificial, passive
🗑
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| what kind of immunity is achieved by DTaP? | show 🗑
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| is passive immunity slow onset with memory? | show 🗑
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| Hiv+ mom gives birth to baby who is sero- at 6 months. What kind of immunity is this an example of? | show 🗑
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| show | process of varying antigenic proteins to hide from the onslaught of the immune system.
🗑
|
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| describe 2 mechanism for antigenic variation | show 🗑
|
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| show | H. influenza
🗑
|
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| show | 2 flagella variants
🗑
|
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| describe the result of Borellia's mechanism of antigenic varaition. | show 🗑
|
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| show | pilus protein
🗑
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| mneumonic for shift and drift | show 🗑
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| define anergy | show 🗑
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| does B-cells undergo anergy? | show 🗑
|
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| show | No, it is immature and naieve with CD4 and CD8 cell srface makrers.
🗑
|
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| when is the T-cell matured? | show 🗑
|
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| How does a T-cell show committment | show 🗑
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| What if it has high affinity for its own class? | show 🗑
|
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| show | Activates Th1 to mediate a CMI response to the mycobacteria tuberculosis antigen.
🗑
|
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| Does encapsulated organisms demonstrate antigenic variation? | show 🗑
|
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| show | CD14
🗑
|
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| What is type II hypersensitivity? | show 🗑
|
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| name examples of type II hypersensitivity | show 🗑
|
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| show | antigen/ab/complement complex which induces PMN's to the area, that releases its lysosomal enzymes causing tissue distruction.
🗑
|
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| show | PAN, immune complex glomerulonephritis, RA, SLE.
🗑
|
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| show | ag/ab complexes, five days post exposure release complement that mediate tissue destruction.
🗑
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| show | fever, uticaria, arthralgias, proteinemia, lymphadenopathy, 5-10 days post exposure.
🗑
|
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| show | via local injection of antigen, where an ag/ab/complement complex forms.
🗑
|
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| example of dz causig arthrus formation | show 🗑
|
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| show | T-cell mediated. Once sensitized T-cells release lymphokines once antigen is encountered
🗑
|
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| Is the reaction immediate? | show 🗑
|
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| In latex allergy, which hypersensitivity is in effect? | show 🗑
|
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| show | T-lymphocytes, Transplant rejection, TB skin test, Touching-contact dermatitis like poison ivy.
🗑
|
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| show | Anaphalactic and atrophic -I, cytotoxic, ab mediated - II, immune complex complement -III, Delayed -IV. ACID
🗑
|
||||
| what is Burton's agammglobinemia? | show 🗑
|
||||
| describe B&T cells combined immune deficiency.SCID | show 🗑
|
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| Cause of SCID? | show 🗑
|
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| show | IL-2 receptor impairement and failure to synthesize MHC II antigens
🗑
|
||||
| show | T-cell IL-2 deficiency.
🗑
|
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| show | hyper IgM syndrome with decreased class switching and loss of humoral limb.
🗑
|
||||
| clinical presentation of hyperIgM. | show 🗑
|
||||
| what is Wiskott-Aldrich syndrome? | show 🗑
|
||||
| show | IgE - normal and low IgM
🗑
|
||||
| show | WIPE: with pyogenic infections, purpura(thrombocytopenic), and Eczema
🗑
|
||||
| What is Job's syndrome? | show 🗑
|
||||
| show | retained primary teeth, recurrent colds, and staph abscess, eczema and coarse features.
🗑
|
||||
| show | Increased levels of IgE
🗑
|
||||
| Diagnosis of B and T-cell defficiences is by what? | show 🗑
|
||||
| How would LAD present? | show 🗑
|
||||
| show | negative CD18 expression
🗑
|
||||
| What is cheiak Higashi? | show 🗑
|
||||
| presentation of Chediak Higashi? | show 🗑
|
||||
| show | defect in phagocytosis of PMN's secondaryto lack of NADPH oxidase activity.
🗑
|
||||
| presentation of CGD | show 🗑
|
||||
| Name infection commonly seen in GCD | show 🗑
|
||||
| show | negative nitroblue tetrozolium dye reduction test is indicative of a t dx.
🗑
|
||||
| show | skin and mucosal membrane candida infections
🗑
|
||||
| All dysfunction of B-cells would presents as | show 🗑
|
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| show | defective isotype switching
🗑
|
||||
| show | IgA
🗑
|
||||
| show | sinus and lung infections. associated with milk allergies and diarrhea.
🗑
|
||||
| show | Defecet is in DNA repair enzymes with associated IgA deficiency
🗑
|
||||
| how else will telangectasia present? | show 🗑
|
||||
| many autoimmune dz pesent with elevated levels of | show 🗑
|
||||
| what kind of lupus presents with high levels of antihistone? | show 🗑
|
||||
| Rhumatoid arthritis | show 🗑
|
||||
| vasculitis | show 🗑
|
||||
| show | anticentromere
🗑
|
||||
| show | anti-scl-70
🗑
|
||||
| show | antimitochrondrial (AST/ALT)
🗑
|
||||
| show | antigliadin
🗑
|
||||
| Good Pasture syndrome | show 🗑
|
||||
| show | antimicrosomal
🗑
|
||||
| show | mmmmmmn
🗑
|
||||
| show | negative nitroblue tetrozolium dye reduction test is indicative of a t dx.
🗑
|
||||
| All dysfunction of T-cells presents as | show 🗑
|
||||
| show | deficiency in a specific clas of imunoglobulin.
🗑
|
||||
| common causes of B-cell deficiency | show 🗑
|
||||
| show | IgA
🗑
|
||||
| how does IgA deficiency present? | show 🗑
|
||||
| What is B-cell ataxia telangectasia? | show 🗑
|
||||
| how else will telangectasia present? | show 🗑
|
||||
| many autoimmune dz pesent with elevated levels of | show 🗑
|
||||
| SLE | show 🗑
|
||||
| show | anti-ds DNA, antismith
🗑
|
||||
| what kind of lupus presents with high levels of antihistone? | show 🗑
|
||||
| Rhumatoid arthritis | show 🗑
|
||||
| show | antineutrophils, C-ANCA, P-ANCA
🗑
|
||||
| scleroderma (CREST) | show 🗑
|
||||
| scleroderma (diffuse) | show 🗑
|
||||
| Good Pasture syndrome | show 🗑
|
||||
| pemphigus vulgaris | show 🗑
|
||||
| polymyositis dermatomyositis | show 🗑
|
||||
| What cell surface protein show a prediliction for certain diseases. | show 🗑
|
||||
| psoriasis, ankylosing spondylitis, IBS, Reiters syndrome | show 🗑
|
||||
| Graves dz. celiac sprue | show 🗑
|
||||
| show | DR2
🗑
|
||||
| DM1 | show 🗑
|
||||
| DM2, Rhumatoid arthritis | show 🗑
|
||||
| pernicious anemia, B12 deficiency, Hashimotor thyroiditis. | show 🗑
|
||||
| show | DR7
🗑
|
||||
| Occurs in minutes ue to preformed ab in transplant recipient against donor antigen | show 🗑
|
||||
| show | acute rejection
🗑
|
||||
| show | Hyperacute NO! acute Yes!
🗑
|
||||
| show | chronic rejection
🗑
|
||||
| is chronic rejection reversible? | show 🗑
|
||||
| show | Grafted Immunocompetent T-cells proliferate in the irradiated immunocompromised host and mount an immune response
🗑
|
||||
| presentation of Graft vs host dz | show 🗑
|
||||
| show | severe organ dysfunction
🗑
|
||||
| what is an autograph? | show 🗑
|
||||
| show | donor is an identical twin
🗑
|
||||
| allogenic? | show 🗑
|
||||
| show | donor is from another species
🗑
|
||||
| show | class switching - humoral division
🗑
|
||||
| genetic difference of aa in heavy/light chains and have no biologic significance. | show 🗑
|
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