Antiaritmice
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Clase antiaritmice | Clasa I - blocante ale Na
Clasa II - blocante B adrenergice
Clasa III - cresc potential de act
Clasa IV - blocante ale Ca
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Clasa I | Ia - scad moderat depol sistolica si cresc PA
Ib - scad slab depol sistolica si scad PA
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Clasa Ia (medicamente-efecte) | Chinidina(oral) - parasimpatolitic (doze mici) , cronotrop- , scade conductibilitatea AV, VD (blocare alfa adrenergice)
Procainamida(i.v) - idem Chinidina, mai putin parasimpatolitic -> urgente aritmice
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Indicatii Clasa Ia | Aritmii atriale si ventriculare: flutter, fibrilatie atriala, TPSV, WPW, extrasistole
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Reactii adverse Clasa Ia | Hipotensiune, bradicardie, agravare BAV , ochi, tinnitus, cefalee, greata, varsaturi.
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Clasa Ib (medicamente) | Lidocaina (i.v) , fenitoina (oral) - se poate folosi cu digitalice, deoarece nu scade viteza de conducere AV , mexiletina
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Clasa Ic (medicamente) | encainida, flecainida
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Clasa III (medicamente) | amiodarona, sotalolul, bretiliul
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Reactii adverse amiodarona | Acumulare in tesuturi: miocard (proaritmogen), pulmonar ( fibroza) , tegument (fotodermita), microdepozite corneene, hipotiroidism
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Clasa IV (medicamente) | verapamil, diltiazem
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Clasa IV (efecte) | cronotrop, batmotrop, dromotrop, inotrop -, VD
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Indicatii clasa IV | Aritmii SV
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