Pharmacology
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| Cyclophosphamide (Cytoxan) | S/E: hemorrhagic cystitis; may be given with Mesna
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| Cisplatin (Platinol) | S/E: Renal toxicity, ototoxicity and severe nause/vomiting. May be administered with Amifostine as a renal protector
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| Paraplatin (Carboplatin) | Given after taxanes to decrease effects of myelosuppression
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| Eloxatin (Oxaliplatin) | May require calcium and magnesium infusions to reduce neurotoxicity; Patients should avoid exposure to cold when receiving this med.
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| Fluorouracil (5 FU) | S/E: GI toxicities, skin changes. Use ice chips PO 10-15 minutes pre- and post- IV bolus to reduce mucositis.
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| Methotrexate (Folex) | S/E: hepatotoxicty. High doses of this are given with Leucovorin rescue.
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| Doxorubicin (Adriamycin) | Lifetime dose of 500 - 550 mg/m2. Streaking or facial flushing indicates drug being administered too quickly. Patient's cardiac ejection fraction should be checked prior to initiation.
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| Blenoxane (Bleomycin) | Lifetime dose = 400 units. Test dose is recommended. Patients should have pulmonary function test prior to initiation.
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| Paclitaxel (Taxol) | Must use non-PVC bag and an inline .22 micron filter. Given first when administered with any 'Platin'.
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| Docetaxel (Taxotere) | Administer drug using non-PVC bag; however NO filter is required.
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| Etoposide (VP16) | S/E: hypotension, especially when given too fast.
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| Vincristine (Oncovin) | S/E: peripheral neuropathies and alopecia. Vesicant. Should never administer more than 2mg.
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| Rituximab (Rituxan) | S/E: high risk for infusion related reactions. Infusion should be increased in increments of 50mg/hr.
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| Trastuzumab (Herceptin) | S/E: infusion reactions, pulmonary toxicity left ventricular cardiac dysfunction. Monoclonal antibody given for breast cancer patients
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| Bortezomib (Velcade) | S/E: peripheral neuropathy. Administered SQ or IV- must rotate sites.
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| Erlotinib (Tarceva) | S/E: rash, diarrhea, GI bleeding/bowel perforation. Oral medication taken on empty stomach.
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| Imatinib mesylate (Gleevec) | S/E: fluid retention, GI bleeding/perforation. Oral medication taken with meal and full glass of water.
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| Hydroxyurea (Hydrea) | S/E: myelosuppression, nausea, vomiting, stomatitis, mucositis. Oral medication (capsule).
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| Darbepoetin (Aransesp) | Growth Colony-Stimulating Factor used for the diagnosis of anemia
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| Filgrastim (G-CSF, Neupogen) | Growth Colony-Stimulating Factor used for the diagnosis of neutropenia
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LauraCannon70
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