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Section 2

Pharmacology

TermDefinition
Cyclophosphamide (Cytoxan) S/E: hemorrhagic cystitis; may be given with Mesna
Cisplatin (Platinol) S/E: Renal toxicity, ototoxicity and severe nause/vomiting. May be administered with Amifostine as a renal protector
Paraplatin (Carboplatin) Given after taxanes to decrease effects of myelosuppression
Eloxatin (Oxaliplatin) May require calcium and magnesium infusions to reduce neurotoxicity; Patients should avoid exposure to cold when receiving this med.
Fluorouracil (5 FU) S/E: GI toxicities, skin changes. Use ice chips PO 10-15 minutes pre- and post- IV bolus to reduce mucositis.
Methotrexate (Folex) S/E: hepatotoxicty. High doses of this are given with Leucovorin rescue.
Doxorubicin (Adriamycin) Lifetime dose of 500 - 550 mg/m2. Streaking or facial flushing indicates drug being administered too quickly. Patient's cardiac ejection fraction should be checked prior to initiation.
Blenoxane (Bleomycin) Lifetime dose = 400 units. Test dose is recommended. Patients should have pulmonary function test prior to initiation.
Paclitaxel (Taxol) Must use non-PVC bag and an inline .22 micron filter. Given first when administered with any 'Platin'.
Docetaxel (Taxotere) Administer drug using non-PVC bag; however NO filter is required.
Etoposide (VP16) S/E: hypotension, especially when given too fast.
Vincristine (Oncovin) S/E: peripheral neuropathies and alopecia. Vesicant. Should never administer more than 2mg.
Rituximab (Rituxan) S/E: high risk for infusion related reactions. Infusion should be increased in increments of 50mg/hr.
Trastuzumab (Herceptin) S/E: infusion reactions, pulmonary toxicity left ventricular cardiac dysfunction. Monoclonal antibody given for breast cancer patients
Bortezomib (Velcade) S/E: peripheral neuropathy. Administered SQ or IV- must rotate sites.
Erlotinib (Tarceva) S/E: rash, diarrhea, GI bleeding/bowel perforation. Oral medication taken on empty stomach.
Imatinib mesylate (Gleevec) S/E: fluid retention, GI bleeding/perforation. Oral medication taken with meal and full glass of water.
Hydroxyurea (Hydrea) S/E: myelosuppression, nausea, vomiting, stomatitis, mucositis. Oral medication (capsule).
Darbepoetin (Aransesp) Growth Colony-Stimulating Factor used for the diagnosis of anemia
Filgrastim (G-CSF, Neupogen) Growth Colony-Stimulating Factor used for the diagnosis of neutropenia
Created by: LauraCannon70