GI Drugs
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| GI motility is controlled by what? | Enteric system: serotonin, dopamine, ANS (sympathetic/parasympathetic)
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| Prokinetic agents are used for what? (increase peristalsis) | gastroparesis, GERD, postop ileus, constipation
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| Cholinomimetics mimic Ach | Bethanchol, rarely used r/t multiple cholinergic SE, activates M3 which promotes GI motility, but secretes acid
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| Metoclopramide | dopamine (D2) receptor antagonist
SE: CNS-restlessness, drowsiness, EPS, coma
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| Macrolides erythromycin IV 3mg/kg | rapid tolerance, increase GI motility, used for short term
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| Bulk & Stimulant laxatives that stimulate GI motility? | Bulk forming - psyllium, methycellulose Osmotic - Magnesium hydroxide, magnesium citrate, sorbitol, lactulose, Stimulant - senna, bisacodyl
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| Drugs that incrase GI motility? | Cholinomimetics, Metoclopramide, Macrolides, Bulk & Stimulant laxatives
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| Bethancol | Cholinomimetics that stimulate GI motility and activate M3 secreting acid, used rarely b/c SE
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| This med is a dopamine (D2) receptor antagonist with SE of CNS-restlessness, drowsiness, EPS, coma and increase GI motility? | Metoclopramide
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| What is erythromycin? | macrolide ABX, rapid tolerance, increase GI motility, used for short term
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| Tegaserod | increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia
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| increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia | Tegaserod
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| What are the Stimulant laxatives that promote GI motility? | Senna and Bisacodyl
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| Stimulate laxatives do what? | increase peristalsis, stimulate enteric system, fluid secretion
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| increase peristalsis, stimulate enteric system, fluid secretion | Stimulate laxatives: senna, bisacodyl
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| What do osmotic laxatives do? | stimulate GI motility
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| Magnesium citrate/hydroxide are what? | osmotic laxatives, can cause hypermagensamia so be careful with renal disease pts.
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| Sorbital | class 3 potassium sparing anti-arrhythmic, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas)
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| Lactulose | reduce ammonia levels, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas)
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| Psyllium, methycellulose | bulk forming laxative, stimulate GI motility, indigestible colloids that absorb water to distend colon and promote peristalsis
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Created by:
cburrows
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