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Increase GI motility

GI Drugs

QuestionAnswer
GI motility is controlled by what? Enteric system: serotonin, dopamine, ANS (sympathetic/parasympathetic)
Prokinetic agents are used for what? (increase peristalsis) gastroparesis, GERD, postop ileus, constipation
Cholinomimetics mimic Ach Bethanchol, rarely used r/t multiple cholinergic SE, activates M3 which promotes GI motility, but secretes acid
Metoclopramide dopamine (D2) receptor antagonist SE: CNS-restlessness, drowsiness, EPS, coma
Macrolides erythromycin IV 3mg/kg rapid tolerance, increase GI motility, used for short term
Bulk & Stimulant laxatives that stimulate GI motility? Bulk forming - psyllium, methycellulose Osmotic - Magnesium hydroxide, magnesium citrate, sorbitol, lactulose, Stimulant - senna, bisacodyl
Drugs that incrase GI motility? Cholinomimetics, Metoclopramide, Macrolides, Bulk & Stimulant laxatives
Bethancol Cholinomimetics that stimulate GI motility and activate M3 secreting acid, used rarely b/c SE
This med is a dopamine (D2) receptor antagonist with SE of CNS-restlessness, drowsiness, EPS, coma and increase GI motility? Metoclopramide
What is erythromycin? macrolide ABX, rapid tolerance, increase GI motility, used for short term
Tegaserod increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia
increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia Tegaserod
What are the Stimulant laxatives that promote GI motility? Senna and Bisacodyl
Stimulate laxatives do what? increase peristalsis, stimulate enteric system, fluid secretion
increase peristalsis, stimulate enteric system, fluid secretion Stimulate laxatives: senna, bisacodyl
What do osmotic laxatives do? stimulate GI motility
Magnesium citrate/hydroxide are what? osmotic laxatives, can cause hypermagensamia so be careful with renal disease pts.
Sorbital class 3 potassium sparing anti-arrhythmic, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas)
Lactulose reduce ammonia levels, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas)
Psyllium, methycellulose bulk forming laxative, stimulate GI motility, indigestible colloids that absorb water to distend colon and promote peristalsis
Created by: cburrows
 

 



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