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Genetics Chapter 17 Human Heredity

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Answer
Pathogens   Disease- causing agents such as viruses, bacteria, fungi, and parasites  
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Skin   A barrier, organisms set up conditions unfavorable to pathogens  
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Innate   Broad , against bacteria in general  
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Adaptive   Specificity, memory, vertebrates  
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Three defenses against infection   Skin, inflammation, and the immune response  
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Complement System   A chemical defense system that kills microorganisms directly, supplements the inflammatory response, and works with (complements) the immune system  
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Membrane Attack Complex   Part of complement cascade, invade microorganism's plasma membrane, create pores through which fluids can flow, creating pores that eventually burst the microorganism  
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Inflammation   Redness Pain Heat Swelling, body's reaction to invading microorganisms, nonspecific active defense system  
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Histamine   A chemical signal produced by mast cells that triggers dilation of blood vessels  
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Genetic predisposition to Crohn disease   Chromosome 16, Chronic inflammation, inflammatory bowel disease (like ulcerative colitis)  
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Immunity   Terrific when targeted at bad guy, but bad when targeted at you. REGULATION IS KEY.  
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Specific responses (Adaptive)   Antibody mediated immunity, and Cell mediated immunity  
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Antibody- mediated immunity   Regulated by B cells and antibody production  
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Cell-mediated immunity   Controlled by T cells  
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Antibodies three main functions   1. Bind to things, Neutralize 2. Opsonize- flag something for a macrophage to eat 3. Kick off complement cascade  
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Lymphocytes   White blood cells that originate in bone marrow and mediate the immune response  
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Stem Cells   Cells in bone marrow that produce lymphocytes by mitotic division  
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B cell   A type of lymphocyte that matures in the bone marrow and mediated antibody- directed immunity, only makes one type of antibody  
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T cell   A type of lymphocyte that undergoes maturation in the thymus and mediates cellular immunity. Programmed in the thymus to produce unique T-cell receptors  
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Antibodies   Y shaped proteins produced by B cells that bind to specific foreign molecules antigens and inactivate them. Secreted by effector cells  
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Antigens   Molecules that initiate antibody production, carried or produced by microorganisms  
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T- cell receptors   Unique proteins on surface of the T cells that bind to specific proteins on the surface of cells infected with viruses, bacteria, or intracellular parasites  
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Binding to an antigen stimulates   B or T cell to divide, producing many clones with the same antibody or TCR - Most polymorphic locus  
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Major hisocompatability complex   Genes on chromosome 6 that encode recognition molecules that prevent the immune system from attacking a body's own organs and tissues.  
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Antibody- mediated immunity (Humoral)   Immune reaction mediated by B cells that protects against invading viruses and bacteria using antibodies produced by plasma cells  
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Cell- mediated immunity   Immune reaction mediated by T cells directed against body cells that have been infected by viruses or bacteria  
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Helper T cell   Stimulates production of antibodies by B cells when an antigen is present. Stimulates division of B cells and cytotoxic T cells  
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Antigen detection   B cells bind to antigens and become antigen presenting cells  
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Activation of helper T cells   Activated helper T cells identify and activate specific B cells  
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Antibody production by B cells   Activated B cells form two types of daughter cells: effector cells and memory B cells  
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Effector cells   Daughter cells of B cells, which synthesize and secrete 2,000 to 20,000 antibody molecules per second into the bloodstream  
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Memory B cell   A long- lived B cell produced after primary exposure to an antigen that plays an important role in secondary immunity  
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Immunoglobulins   Five classes of proteins to which antibodies belong ( IgG IgA IgE IgM IgD)  
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Cytokines   Made by T cells  
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Suppressor T cells   Stop immune responses of B cells, other T cells  
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Cytotoxic "killer" T cells   Secrete perforin to destroy infected body cells, and directly attack viruses, bacteria, cancer cells and transplanted organs  
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