HIV ARV therapy
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| Zidovudine | NRTI
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| Abacavir | NRTI
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| Lamivudine | NRTI
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| Emtricitabine | NRTI
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| Didanosine | NRTI
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| Stavudine | NRTI
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| Tenofovir | NRTI (nucleoTide)
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| Class toxicities: lactic acidosis, hepatomegaly | NRTI
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| AE: mostly myelosuppression; anemia, neutropenia, HA, malaise | ZIdovudine (AZT)
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| BBW: non-cirrhotic portal HTN; AE: pancreatitis, CD4 toxicity with Tenofovir (TDF) | Didanosine (ddI)
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| AE: peripheral neuropathy, mitochondrial toxicities, lipoatrophy | Stavudine (d4T)
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| benign drugs with little toxicities; HA, N/V/D | Lamivudine (3TC)
Emtricitabine (FTC)
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| hypersensitivity--check allele; doesn't work viral load >100,00, penetrates CNS well | Abacavir (ABC)
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| renal dysfunction--Fanconi's syndrome | Tenofovir (TDF)
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| drugs with activity against HBV | Tenofovir
Lamivudine
Emtricitabine
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| Efavirenz | NNRTI
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| Nevirapine | NNRTI
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| Delavirdine | NNRTI
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| Etravirine | NNRTI
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| Rilpivirine | NNRTI
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| class toxicites: hepatotoxicity, rash | NNRTIs
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| K103 mutations is responsible for resistance in these ARVs | Efavirenz
Nevirapine
Delavirdine
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| Contraindicated with PPIs | Rilpivirine
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| Atazanavir | PI
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| Darunavir | PI
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| Nelfinavir | PI
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| Saquinavir | PI
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| Ritonavir | PI
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| Indinavir | PI
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| Lopinavir | PI
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| Tipranavir | PI
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| Fosamprenavir | PI
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| AE: Jaundice, scleral icterus, cholelithiasis, nephrolithiasis, requires acidic pH | Atazanavir
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| AE: N/V/D; take with food to increase bioavail | Darunavir
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| rarely used; really bad diarrhea | Nelfinavir
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| rarely used; prolong QT interval | Saquinavir
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| not an active PI anymore; pharmaco-enhancer | Ritonavir
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| not used often; nephrolithiasis | Indinavir
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| has Ritonavir in formulation; good pregnancy data | Lopinavir
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| salvage drug--higher dose; AE: intracranial bleed | Tipranavir
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| Raltegravir | Intergrase inhibitor
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| AE: severe rash, CPK | Raltegravir
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| Maraviroc | Entry inhibitor
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| must be CCR5 dominant | Maraviroc
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| BBW: hepatotoxicity | Maraviroc
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| Fusion inhibitor; last line therapy; no DDI because it's a very large peptide | Fuzeon
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| Sulfa allergy caution use of: | Darunavir
Fosamprenavir
Tipranavir
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| AE: depression (Psychiatric disorders), insomnia, HA, rash | Rilpivirine
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Created by:
simpsonan
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