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notes to study for quiz

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Term
Definition
cancer   malignant tumor  
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oncology   study of cancer  
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neoplasm   tumor-new growth that serves no purpose-uncontrollable & progressive  
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benign   growth is slow & incapsulated  
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malignant   fast growing & spreads-competes for space & blood supply  
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carcinoma   solid tumor, made up in or of epithelial cells, it is most common type of cancer (breast, colon, liver, lung, stomach, prostate)  
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sarcoma   made from supportive & connective tissue-can be in bone, fat, mm or cartilage  
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leukemia   blood-forming tissues w/in bone marrow. can be acute or chronic- large # of abnormal WBC that infiltrate bone marrow- can spread out to other areas-crowds out normal cells  
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lymphoma   hodgkins or non-hodgkins- cancer of lymphatic system. (non-hodgkins more common)  
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risk factors/carcinogens for cancer dev   age, genetics, diet, virus, chemicals, UV, radiation, alcohol abuse, smoking, some hormones, certain medications, previous cancer, lower income, occupational hazards, stress, precancerous lesions  
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heredity + carcinogen =   DNA mutation  
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DNA mutation leads to   tissue change + immune dysfunction  
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hyperplasia   excessive growth  
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dysplasia   abnormal growth  
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anaplasia   loss of differenciation between tumor cells and normal cells  
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cancer progression   local -> invasive -> metastatic  
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local   have not yet spread from site of original tumor  
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invasive   spreads to other sites in same region of the body  
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metastatic   2nd tumor in another area not close to 1st one  
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most common sites of metastasis   pulmonary, hepatic, CNS, skeletal  
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common sites of skeletal metastasis   skull, pelvis, ribs, spine, proximal femur, proximal humerus  
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skeletal metastasis complications   bone pain, pathological fx, spinal cord injury (SCI)  
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clinical manifestations systemic   no appetite, rapid wt loss, fatigue, weakness, hemorrhage, vomiting  
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clinical manifestations pain   usually have pn but not always  
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clinical manifestations organ specific   example: if lungs- having breathing problems  
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methods to dx cancer   Hx & PE, biopsy, tumor markers  
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grading   degress of anaplasia, grade 1 is better than grade 4  
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TNM   staging-how they classify tumors-T= size & extent of primary tumor- N=# of notdes- M=metastasis  
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prognosis   depends on type of cancer, when it's diagnosed, if you have 5 years of remission  
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prevention of CA   identify risk factors and avoid them, pt edu, regular screenings  
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CA sx   almost always done (remove tumor & bone marrow transplants)  
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radiation therapy   done by x-ray machine or they will insert radio-isotope like IV  
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chemotherapy   immuno-suppressant- decreased WBC count-most effective on metastatic cancer-can be done orally or by injection  
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biotherapy   strengthen immune response-uses interferon (protein) to kill cancer cells  
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hormones   different types-a lot of rx therapies will affect hormones  
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side effects   nausea & vomiting, fatigue, immunosuppression, anemia, may decrease level of H&H in RBC, hair loss, burns  
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curative vs palliative   sometimes we try to cure, sometimes just try to make pt more comfortable  
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PT contra/precautions   -modalites (some can't be done w/CA)- WBC count below 5000 or RBC below 25% places limits on activity  
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rx options   strength & endurance, keep normal function as long as possible, energy conservation, work simplification, use RPE scale, function, fall prevention, adapting environment, maybe recommend AD & fit, caregiver training, positioning, bed mob & trnsf, pn manage  
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insulin   produced by beta cells in Islets of Langerhans, which is in pancreas. moves glucose from blood to cells or to liver  
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type I DM   insulin dependent, no insulin production, onset under 30 yrs, less than 10% of cases, abrupt onset, normal thin body type, ketoacidosis may occur  
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type II DM   non-insulin dependent, caused by increased resistance to insulin, onset over 40 yrs, more than 90% of cases, gradual onset, obese body type, ketoacidosis rare  
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risk factors DM   heredity, family hx, ethnicity, old age, gestational DM, obesity & inactivy, hypertension, HDL's less than 35 or triglyceride over 250, hx of vascular disease  
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cardinal signs of DM   glucouria (glycosuria-glucose in urine), polyuria (frequent urination), polydipsia (extreme thirst), polyphagia (extreme hunger), ketouria (ketones in urine), weakness, fatigue  
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clinical manifestations of DM-vascular-small vessel dx   retinopathy, kidney dx  
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clinical manifestations of DM-vascular-large vessel dx   CAD, MI, CVA, PVD (heart attack main cause of death)  
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clinical manifestations of DM-impaired healing   increased risk for infections: skin, UTI, vaginal  
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clinical manifestations of DM- musculoskeletal   multiple problems, osteoporosis, we rx with light resistance and wt bearing, not too heavy a load and careful stretching  
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clinical manifestations of DM- neuropathy   symptoms move distal to proximal, SENSORY- cutaneous, proprioception, increase injury, rocker bottom foot. MOTOR-weakness, claw toes, flat foot. AUTONOMIC-no sweating  
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DM diagnosed...   by blood sugar levels- HYPO-less than 70- HYPER- more than 250  
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clinical signs of hyperglycemia   dehydration, ketoacidosis, thirst, abdominal pn, N&V, lethargy, LOC, coma, fruity breath, dry mouth, skin  
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clinical signs of hypoglycemia   faint, shaky, sweating, speech disturbance, double vision, cloudy, LOC, coma, HA  
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