Cirrhosis Drugs
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non-selective ß-blocker causes splanchnic vasoconstriction | nadolol
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decreases intestinal NH3 by acting against urease producing bacteria | neomycin sulfate
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somatostatin analog; inhibits serotonin, gastrin, insulin, glucagon and alters mesenteric/sphlanchnic blood flow promoting hemostasis | octreotide
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inhibits binding of aldosterone to receptor | spironolactone
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inhibits sodium-potassium symport in ascending limb | furosemide
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used in cirrhosis induced hepatic encephalopathy | neomycin sulfate
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used for bleeding esophageal varicies | octreotide and nadolol
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used for cirrhosis induced edema | spironolactone and furosemide
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causes nephro and ototoxicity | neomycin sulfate
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causes gynecomastia | spironolactone
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monitor B12 levels, cholelithiasis, hypothyroidism, anemia | octreotide
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avoid NSAIDs | spironolactone and furosemide
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aides in hydrolysis of fats, proteins and starches | pancrelipase
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interacts with iron salts, iron, multivitamins | pancrelipase
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monitor growth and development | pancrelipase
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titrate "low and go slow" | pancrelipase
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how do you monitor the effectivity of neomycin sulfate? | clinical improvement
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used after removal of >5L paracentesis | albumin 25%
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how long for diuretics to reach "steady state"? and how often should you adjust dose? | 3-5 days
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don't use with DM or renal impairment | octreotide
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which 2 cirrhosis drugs are pricy? | octreotide and albumin 25%
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