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important human viruses and their properties

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Virus
Clinical Importance
Group
Variola   smallpox virus, produces systemic infection with characteristic vesicular rash affeacting face, arms and legs, has a high mortality rate   DNA Viruses poxviruses  
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Vaccinia   derived from cowpox virus, immunize against smallpox   DNA Viruses poxviruses  
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Adenovirus   cause URT infections, produce latent infections in tonsil and adenoids, produce tumors on inj into hamsters, rats or mice   DNA Viruses adenoviruses  
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Herpes simplex virus (HSV1 and HSV2)   HSV1 infects oral membranes HSV2 is responsible for recurrent genital herpes   DNA Viruses herpesviruses  
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Varicella zoster virus (VZV)   causes chickenpox in children, shingles in elderly   DNA Viruses herpesviruses  
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Cytomegalovirus (CMV)   a subclinical infection, causes severe disease in immunocompromised patients, can induce serious congenital abnormalities in the fetus   DNA Viruses herpesviruses  
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Epstein-Barr virus (EBV)   infection by salivary exchange, asmyptomatic, persists in latent form in lymphocytes, results glandular fever, malignant facial tumors (Burkitt's lymphoma) in children   DNA Viruses herpesviruses  
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Hepatitis B virus (HBV)   infection in children by prenatal transmission, contaminated blood or sexual transmission, can progress liver cancer   DNA Viruses hepatitis viruses  
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Papilloma virus   multiply in epithelial cells of skin and mucous membranes causing warts, associated with cervical carcinoma   DNA Viruses papovaviruses  
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Mumps virus   swelling of parotid and submaxillary salivary glands, has neurological complications   RNA Viruses paramyxoviruses  
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Measles virus   common childhood fever   RNA Viruses paramyxoviruses  
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Rabies virus   has very wide host range, can cause fatal encephalitis   RNA Viruses rhabdoviruses  
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Rotavirus   causes gastroenteritis, spread through poor water supplies and low general hygiene   RNA Viruses reoviruses  
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Poliovirus   multiplies in lymphoid tissue of alimentary tract   RNA Viruses picornaviruses  
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Rhinoviruses   common cold virus, shed in watery nasal secretions   RNA Viruses picornaviruses  
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Hepatitis A virus (HAV)   responsible for infectious hepatitis, spread by oral-faecal route   RNA Viruses picornaviruses  
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Rubella   causes german measles in children, can induce severe multiple congenital abnormalities   RNA Viruses togaviruses  
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Yellow fever virus   spread by mosquito bites, with liver as main target, necrosis of hepatocytes leads to jaundice and fever   RNA Viruses flaviviruses  
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Hepatitis C virus (HCV)   spread through blood transfusions and blood products   RNA Viruses flaviviruses  
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Ebola virus   widespread in monkeys, spread through body fluids, results in hemorrhagic fever   RNA Viruses filoviruses  
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Human T-cell leukaemia virus (HTLV-1)   spread in infected lymphocytes in blood, semen or breast milk   RNA Viruses retroviruses  
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Human immunodeficiency virus (HIV)   transmitted via blood or genital secretions, induces immunodeficiency   RNA Viruses retroviruses  
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Hepatitis D virus (HDV)   exacerbates pathogenic effects of HBV producing severe hepatitis   RNA Viruses hepatitis viruses  
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Influenza virus   capable of extensive antigenic variation, causes pandemics of influenza, multiplies in cells lining URT, symptoms caused by absorption of toxic breakdown products   RNA Viruses myxoviruses  
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