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Biotech-Get a Clue

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Term
Definition
Codis(Combined DNA Index System)   Is the generic term used to describe the FBI’s program of support for criminal justice DNA databases as well as the software used to run these databases.  
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Relp(Residual-excited linear prediction)   Is an obsolete speech coding algorithm. It was originally proposed in the 1970s and can be seen as an ancestor of code-excited linear prediction (CELP). Unlike CELP however, RELP directly transmits the residual signal.  
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Sticky Ends   Refers to the properties of the end of a molecule of DNA or a recombinant DNA molecule. The concept is important in molecular biology, especially in cloning or when subcloning inserts DNA into vector DNA.  
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DNA Fingerprints   Biometric identification obtained by examining a person's unique sequence of DNA base pairs; often used for evidence in criminal law cases.  
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Cleave   In an optical fiber, a deliberate, controlled break, intended to create a perfectly flat endface, perpendicular to the longitudinal axis of the fiber. To break a fiber in such a controlled fashion.  
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DNA(deoxyribonucleic acid)   Compare with nucleic acid and nucleotide .A nucleic acid with 2-deoxy-D-ribose as the sugar in its nucleotides . DNA contains encoded genetic information, specifically templates for the synthesis of all of an organism's proteins and enzymes .  
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Comb   Is a toothed device used in hair care for straightening and cleaning hair or other fibres. Combs are among the oldest tools found by archaeologists, having been discovered in very refined forms from settlements dating back to 5,000 years ago in Persia.  
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Restriction Enzyme   Is an enzyme that cuts DNA at specific recognition nucleotide sequences known as restriction sites. Such enzymes, found in bacteria and archaea, are thought to have evolved to provide a defense mechanism against invading viruses.  
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Exclusion   In the asbestos program, one of several situations that permit a Local Education Agency (LEA) to delete one or more of the items required by the Asbestos Hazard Emergency Response Act (AHERA)  
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Hybridization   The specific reassociation of complementary strands of nucleic acids.  
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VNTR(Variable number tandem repeat)   Is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length between individuals.  
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Nucleotides   A nucleoside in which the sugar carries at least one phosphate group; nucleotides are the subunits that make up nucleic acid.  
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Gel Lanes   A method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge.  
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DNA Fragments   When exposed to photo-graphic film, reveal an image of the DNA.  
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Palindrome   Is a word, phrase, number, or other sequence of units that may be read the same way in either direction, with general allowances for adjustments to punctuation and word dividers.  
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Wells   Producing services related to the production of crude or natural gas.  
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STR(Short tandem repeat)   Occurs in non-coding region when a pattern of two or more nucleotides are repeated and the repeated sequences are directly to each other..  
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Electric Field   Is the region of space surrounding electrically charged particles and time-varying magnetic fields. The electric field depicts the force exerted on other electrically charged objects by the electrically charged particle the field is surrounding.  
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Inclusion   A foreign object present within, for example, an optical fiber or a crystal.  
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Microliter   Unit of liquid volume equal to one millionth of a liter  
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Human Genome   Complete map of all genes in human DNA, all of the DNA of a person.  
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Blunt Cut   When the endonuclease makes a clean cut, the two ends of the new molecules.  
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Buffer   A solution that can maintain its pH value with little change when acids or bases are added to it. Buffer solutions are usually prepared as mixtures of a weak acid with its own salt or mixtures of salts of weak acids.  
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Recombinant DNA   The new DNA that is formed by combining pieces of DNA from different organisms or cells.  
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DNA Polymerase   A group of enzymes mainly involved in copying a single-stranded DNA molecule to make its complementary strand. Eukaryotic DNA polymerases participate in chromosomal replication, repair, crossing-over and mitochondrial replication.  
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Gene   Physical and functional unit of heredity that carries information from one generation to the next. The entire DNA sequence necessary for the synthesis of a functional polypeptide or RNA molecule.  
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Digital Micropipet   A pipette designed for the measurement of very small volumes.  
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Staggered Cut   The cleavage of two opposite strands of duplex DNA at points near one another.  
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Agarose Gel   A method of gel electrophoresis used in biochemistry, molecular biology, and clinical chemistry to separate a mixed population of DNA or proteins in a matrix of agarose.  
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Inconclusive   Not decisive, unconvincing; not decided; not resulting in a final conclusion.  
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Fingerprint   Mark made by a fingertip on any surface (especially prints made with ink for identification purposes. Record the fingerprints of a person.  
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Luminol   A versatile chemical that exhibits chemiluminescence, with a striking blue glow, when mixed with an appropriate oxidizing agent.  
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PCR(Polymerase chain reaction)   A technique which allows amplification of specific DNA segments in a very short time.  
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Restriction Site   are locations on a DNA molecule containing specific(4-8 base pairs in length)sequences of nucleotides, which are recognized by restriction enzymes.  
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Gel Electrophoresis   A method used in clinical chemistry to separate proteins by charge and size in biochemistry and molecular biology to separate a mixed population of DNA and RNA fragments by length.  
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Evidence   Proof, something which proves or disproves. Offer proof, prove, show to be true.  
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