Antiemetics
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each of the black spaces below before clicking
on it to display the answer.
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| Antihistamines: have strong anticholinergic effects | Dramamine,benadryl,vistaril,antivert
especially helpful in n/v associated with motion sicknessb/c of their depression of conduction in the vestibulocerebellar pathway
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| phenothiazines: block dopamine receptors in the chemoreceptor trigger zone[CTZ], also bind to and block cholinergic, alpha1-adrenergic, and histamine 1 | Phenergan, Compazine cross the blood brain barrier
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| cannabinoid | dronabinol[Marinol]
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| 5HT3 receptor antagonists: block serotonin both peripherally on vagal nerve terminals and centrally in the CTZ | Aloxi, Anzemet, Kytril, Zofran
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| miscellaneous drug: inhibits emetic stimulation of the CTZ | Tigan
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| Antihistamines: precautions and contraindications | [b/c of anticholinergic effects], glaucoma, seizure, pyloric obstruction, hyperthyroidism, cardiovascular, prostatic hypertrophy
contraindicated in severe liver disease
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| phenothiazines: precautions and contraindications | contraindicated in Parkinson's, narrow angle glaucoma, bone marrow depression, severe cardiovascular or hepatic disease
use cautiously in respiratory disease[silent pneumonia may develop], or where aspiration is a risk
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| cannabinoid: precautions and contraindications | allergy to sesame oil, may lower the seizure threshold
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| 5HT 3 receptors: precautions | may mask progressive ileus, Zofran ODT contains aspartame and should be used with caution in pts with phenylketonuria
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| long term use of phenothiazines has been associated with blood dyscrasia that occur when | between 4-10 weeks of therapy
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