Classic Findings
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| show | Often precedes squamous cell carcinoma
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| show | 1° adrenocortical deficiency
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| Albright’s syndrome | show 🗑
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| Albuminocytologic dissociation | show 🗑
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| show | Hereditary nephritis with nerve deafness
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| show | Goodpasture’s syndrome
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| Anticentromere antibodies | show 🗑
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| Anti-double-stranded DNA antibodies (ANA antibodies) | show 🗑
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| show | Pemphigus vulgaris
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| Antigliadin antibodies | show 🗑
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| show | Drug-induced SLE
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| show | Rheumatoid arthritis
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| Antimitochondrial antibodies | show 🗑
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| show | Vasculitis
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| Anti platelet antibodies. How to treat? | show 🗑
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| show | Marfan’s syndrome, Ehlers Danlos
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| show | Neurosyphilis
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| show | Cerebellar tonsillar herniation
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| Aschoff bodies | show 🗑
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| Atrophy of the mammillary bodies | show 🗑
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| Auer rods | show 🗑
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| Autosplenectomy | show 🗑
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| Babinski’s sign | show 🗑
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| show | Rheumatoid arthritis
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| show | Ankylosing spondylitis
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| show | Hyperreninemia
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| Basophilic stippling of RBCs | show 🗑
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| Becker’s muscular dystrophy | show 🗑
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| Bell’s palsy | show 🗑
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| Bence Jones proteins | show 🗑
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| show | IgA nephropathy
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| show | Defect in platelet adhesion
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| Bilateral hilar adenopathy, uveitis | show 🗑
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| Birbeck granules on EM | show 🗑
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| show | Subarachnoid hemorrhage
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| show | Chronic bronchitis
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| Blue-domed cysts | show 🗑
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| Blue sclera | show 🗑
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| show | Tetralogy of Fallot; RVH
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| show | Osteoarthritis (PIP swelling 2° to osteophytes)
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| Boutonnière deformity | show 🗑
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| Branching rods in oral infection | show 🗑
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| show | Hemorrhage causes brown color of osteolytic cysts: 1. Hyperparathyroidism 2. Osteitis fibrosa cystica (von Recklinghausen’s disease)
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| Brushfield’s spots | show 🗑
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| Bruton’s disease | show 🗑
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| show | Posthepatic venous thrombosis
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| show | Small/medium-artery vasculitis (thromboangiitis obliterans), vessels blocked with thrombi, particularly in the legs, leading to gangrene. Associated with smoking.
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| show | 8:14 translocation; associated with EBV
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| show | Lead poisoning
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| C-ANCA, P-ANCA | show 🗑
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| show | Neurofibromatosis– autosomal dominant disorder with developmental delay and neuro fibromas found on the skin.
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| Caisson disease | show 🗑
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| Calf pseudohypertrophy | show 🗑
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| Call-Exner bodies | show 🗑
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| Cardiomegaly with apical atrophy | show 🗑
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| show | Mycosis fungoides (cutaneous T-cell lymphoma)
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| show | Trypanosome infection
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| show | 1° syphilis (not painful)
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| show | Haemophilus ducreyi (painful)
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| Charcot’s triad | show 🗑
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| show | Hexagonal bipyramidal structures in basophils and eosinophils - Bronchial asthma (eosinophil membranes) or parasitic pneumonia
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| show | Phagocyte deficiency --> Recurrent infections(Staph aureus and gram neg organisms), albinism, peripheral neuropathy. Light skin with silver hair, often with solar sensitivity. Autosomal recessive.
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| show | Tay-Sachs (autosomal recessive, developmental delay because of ganglioside accumulation in brain), Riemann-Pick disease (lysosomal storage disease, autosomal recessive, unsteady gait/dysarthria/dysphasia), central retinal artery occlusion
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| Cheyne-Stokes respirations | show 🗑
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| “Chocolate cysts” | show 🗑
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| Chronic atrophic gastritis | show 🗑
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| Spasm upon tapping the face muscles | show 🗑
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| Clear cell adenocarcinoma of the vagina | show 🗑
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| Clue cells | show 🗑
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| Codman’s triangle on x-ray | show 🗑
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| Cold agglutinins | show 🗑
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| Cold intolerance | show 🗑
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| show | 2° syphilis
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| show | Patent ductus arteriosus
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| show | Debranching enzyme deficiency
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| show | Fluffy white patches on the retina - indicative of diabetic or hypertensive retinopathy
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| Cough, conjunctivitis, coryza + fever | show 🗑
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| Councilman bodies | show 🗑
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| show | Eosinophilic nuclear inclusions composed of nucleic acid and protein seen in cells infected with Herpesvirus
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| Crescents in Bowman’s capsule | show 🗑
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| show | Congenital unconjugated hyperbilirubinemia
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| Curling’s ulcer | show 🗑
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| show | Klebsiella
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| Curschmann’s spirals | show 🗑
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| Cushing’s ulcer | show 🗑
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| show | DIC
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| Depigmentation of neurons in substantia nigra | show 🗑
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| show | Pellagra (niacin, vitamin B3 deficiency)
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| show | histiocytosis X (Hand-Schiller-Christian disease)
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| Dog or cat bite | show 🗑
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| show | Granuloma inguinal Caused by Klebsiella granulomatous, Ulcerative painless genital lesions.
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| Dressler’s syndrome | show 🗑
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| show | Congenital conjugated hyperbilirubinemia (black liver)
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| show | Deleted dystrophin gene (X-linked recessive). Muscle degeneration. muscle replaces with fat and fibrosis. Progressive proximal muscle weakness w loss of muscle mass. Pseudo-hypertrophy of calves + deltoid muscles. Difficult to walk upstairs
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| Eburnation | show 🗑
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| Edwards’ syndrome | show 🗑
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| Eisenmenger’s complex | show 🗑
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| Elastic skin | show 🗑
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| Erb-Duchenne palsy | show 🗑
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| Erythema chronicum migrans | show 🗑
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| Fanconi’s syndrome | show 🗑
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| “Fat, female, forty, and fertile” | show 🗑
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| Fatty liver | show 🗑
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| Ferruginous bodies | show 🗑
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| Gardner’s syndrome | show 🗑
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| show | Glucocerebrosidase deficiency --> Causes glucocerebroside to accumulate in spleen, liver, kidneys, lungs, brain, bone marrow.
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| Ghon focus | show 🗑
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| Gilbert’s syndrome | show 🗑
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| Glanzmann’s thrombasthenia | show 🗑
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| Goodpasture’s syndrome | show 🗑
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| Gowers’ maneuver | show 🗑
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| Guillain-Barré syndrome | show 🗑
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| show | β-thalassemia, sickle cell anemia (extramedullary hematopoiesis)
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| show | Chronic progressive histiocytosis - Proliferation of epidermal dendritic cells, can affect almost any organ
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| HbF | show 🗑
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| show | Sickle cell anemia
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| show | Choriocarcinoma, hydatidiform mole (occurs with and without embryo)
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| Heberden’s nodes | show 🗑
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| Heinz bodies | show 🗑
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| show | Hypersensitivity vasculitis associated with hemorrhagic urticaria and URIs
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| Heterophil antibodies | show 🗑
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| High-output cardiac failure (dilated cardiomyopathy) | show 🗑
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| HLA-B27 | show 🗑
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| HLA-DR3 or -DR4 | show 🗑
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| show | Neuroblastoma
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| Honeycomb lung on x-ray | show 🗑
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| Horner’s syndrome | show 🗑
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| Howell-Jolly bodies | show 🗑
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| Huntington’s disease | show 🗑
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| show | Klüver-Bucy syndrome (amygdala)
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| Hyperpigmentation of skin | show 🗑
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| Hypersegmented neutrophils | show 🗑
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| show | Conn’s syndrome - hyperdaldosteronism
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| show | Iron deficiency anemia, lead poisoning
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| show | Anencephaly, spina bifida (neural tube defects)
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| Increased uric acid levels | show 🗑
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| Intussusception | show 🗑
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| Janeway lesions | show 🗑
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| Jarisch-Herxheimer reaction | show 🗑
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| show | Neutrophil chemotaxis abnormality
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| Kaposi’s sarcoma | show 🗑
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| Kartagener’s syndrome | show 🗑
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| Kayser-Fleischer rings | show 🗑
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| Keratin pearls | show 🗑
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| Kimmelstiel-Wilson nodules | show 🗑
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| Klüver-Bucy syndrome | show 🗑
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| show | Squamous epithelial cell from cervix that has nuclear enlargement – 2 to 3 times normal size - nuclear membrane irregularity, and hyperchromasia. Denotes HPV Infection.
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| show | Clustered, white lesions on buccal mucosa, pathognomonic for Measles
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| Krukenberg tumor | show 🗑
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| show | Diabetic ketoacidosis
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| show | Marfan’s syndrome (fibrillin deficit)
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| Lesch-Nyhan syndrome | show 🗑
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| Lewy bodies | show 🗑
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| Libman-Sacks disease | show 🗑
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| show | Arterial thrombus
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| Lisch nodules | show 🗑
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| show | Wilson’s disease
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| Lucid interval | show 🗑
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| “Lumpy-bumpy” appearance of glomeruli on immunofluorescence | show 🗑
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| Lytic bone lesions on x-ray | show 🗑
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| Mallory bodies | show 🗑
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| Mallory-Weiss syndrome | show 🗑
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| McArdle’s disease | show 🗑
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| McBurney’s sign | show 🗑
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| medial longitudinal fasciculus (MLF) syndrome (internuclear ophthalmoplegia - eyes don't move together when ABducting) | show 🗑
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| Monoclonal antibody spike | show 🗑
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| show | Hypothyroidism
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| show | Wegener’s and Goodpasture’s (hemoptysis and glomerular disease)
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| show | Gout
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| show | Rabies
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| Nephritis + cataracts + hearing loss | show 🗑
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| show | Alzheimer’s disease
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| show | Sphingomyelinase deficiency - sphingomyelin accumulates in lysosomes in cells. The lysosomes normally transport material through and out of the cell. Leads to HSM and TCP.
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| No lactation postpartum | show 🗑
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| Nutmeg liver | show 🗑
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| show | Malignant mesothelioma
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| “Orphan Annie” nuclei | show 🗑
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| Osler’s nodes | show 🗑
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| show | CMV
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| show | Pancreatic cancer (head)
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| Palpable purpura on legs and buttocks | show 🗑
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| show | Bronchogenic apical tumor associated with Horner’s syndrome
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| Pannus | show 🗑
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| show | Nigrostriatal dopamine depletion
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| show | Pyogenic osteomyelitis
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| show | Benign polyposis. Hamartomas of small intestine. STK11. Pigmented lesions on skin, lips, mouth.
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| Peyronie’s disease | show 🗑
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| Philadelphia chromosome (bcr-abl ) | show 🗑
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| show | Pick’s disease - Frontotemporal dementia and aphasia. Spherical bodies made of Tau proteins in neurons (Pick bodies)
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| Pick’s disease | show 🗑
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| “Pink puffer” | show 🗑
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| Plummer-Vinson syndrome | show 🗑
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| Podagra | show 🗑
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| show | Minimal change disease
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| show | Dry beriberi (thiamine, vitamin B1 deficiency)
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| show | Guillain-Barré syndrome
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| Pompe’s disease | show 🗑
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| Port-wine stain | show 🗑
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| Positive anterior “drawer sign” | show 🗑
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| show | Vertebral tuberculosis
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| Pseudopalisade tumor cell arrangement | show 🗑
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| show | Ewing’s sarcoma - Small, round, malignant blue cell tumor found in the bone, most commonly in the pelvis, femur, humerus, ribs, clavicle. Translocation between chromosomes 11 and 22. Negative for CD45. Diagnosed on x-ray with lytic lesion and onion skin p
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| show | Horner’s syndrome (Pancoast’s tumor)
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| show | 2° syphilis, Rocky Mountain spotted fever
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| show | Recurrent vasospasm in extremities
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| show | Acute glomerulonephritis
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| show | Cystic fibrosis
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| Red urine in the morning | show 🗑
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| show | Hodgkin’s lymphoma
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| Reid index (increased) | show 🗑
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| Reinke crystals | show 🗑
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| show | Urethritis, conjunctivitis, arthritis
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| show | von Hippel–Lindau disease
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| show | Acute toxic/viral nephrosis
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| Rhomboid crystals, positively birefringent | show 🗑
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| show | Coarctation of aorta
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| show | Retinal hemorrhages with white or pale centers. Differential includes Endocarditis, diabetic retinopathy, hypertensive retinopathy. Usually due to immune complex deposition.
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| show | Congenital conjugated hyperbilirubinemia
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| show | Multiple myeloma
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| show | Multiple myeloma
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| show | Left-to-right shunt (VSD, PDA, ASD), mitral regurgitation, LV failure (CHF)
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| S4 | show 🗑
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| Schiller-Duval bodies | show 🗑
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| show | Extracellular deposits of amyloid in the gray matter of the brain. Alzheimer’s disease
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| Sézary syndrome | show 🗑
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| Sheehan’s syndrome | show 🗑
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| Shwartzman reaction- Tissue necrosis and thrombosis in response to endotoxin | show 🗑
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| Signet-ring cells | show 🗑
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| show | Down syndrome
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| Sipple’s syndrome | show 🗑
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| Sjögren’s syndrome | show 🗑
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| show | Crohn’s
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| Slapped cheeks | show 🗑
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| Smith antigen | show 🗑
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| “Smudge cell” | show 🗑
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| show | Giant cell tumor of bone
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| Spike and dome on EM | show 🗑
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| show | Benign juvenile melanoma
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| show | Endocarditis
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| Starry-sky pattern | show 🗑
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| “Strawberry tongue” | show 🗑
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| show | On ultrasound, you just see a streak of fibrous tissue in the expected location of the ovaries. This tissue may contain very few or no ovarian follicles. Turner’s syndrome
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| String sign on x-ray | show 🗑
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| Subepithelial humps on EM | show 🗑
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| show | Rubella
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| Sulfur granules | show 🗑
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| Swollen gums, bruising, poor wound healing, anemia | show 🗑
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| Systolic ejection murmur (crescendo-decrescendo) | show 🗑
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| t(8;14) | show 🗑
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| t(9;22) | show 🗑
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| t(14;18) | show 🗑
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| show | 3° syphilis
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| Tendon xanthomas (classically Achilles) | show 🗑
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| Thumb sign on lateral x-ray. What organism? | show 🗑
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| Thyroidization of kidney | show 🗑
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| show | Gout
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| show | Separation of basement membrane due to Miss Angela growth. Membranoproliferazive glomerulonephritis - Low C3, very low C4, nephritis associated with hepatitis C > hepatitis B, subacute bacterial endocarditis, lupus, cryo- globulinemia.
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| Trousseau’s sign - With occlusion of the brachial artery, absence of blood flow will cause spasm of the hand muscles So that the wrist flexes and the finger joints extend, with all the fingers adducted to a point. | show 🗑
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| show | Left supraclavicular node enlargement from metastatic carcinoma of the stomach
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| Virchow’s triad | show 🗑
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| von Recklinghausen’s disease | show 🗑
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| show | Osteitis fibrosa cystica (“brown tumor”). Caused by hyperparathyroidism, which leads to inc osteoclasts activity, inc bone resorption, dec bone mass, and bone calcification replaced by cyst-like brown tumors that have a moth-eaten appearance on X-ray. Ca
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| Wallenberg’s syndrome | show 🗑
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| show | Adrenal hemorrhage associated with meningococcemia
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| show | Chronic end-stage renal disease
🗑
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| show | Acute pyelonephritis
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| WBCs in urine | show 🗑
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| Wermer’s syndrome | show 🗑
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| Whipple’s disease | show 🗑
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| show | Hepatolenticular degeneration
🗑
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| “Wire loop” appearance on LM | show 🗑
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| “Worst headache of my life” | show 🗑
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| show | Subarachnoid hemorrhage
🗑
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| show | Sjögren’s syndrome
🗑
|
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| Zenker’s diverticulum | show 🗑
|
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| Zollinger-Ellison syndrome | show 🗑
|
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