DVT + PE
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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Argatroban; What is it for? | Direct thrombin inhibitor;
Used to tx HIT
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HIT How is it formed? | Heparin-Induced Thrombocytopenia
Immune-mediated rxn--> IgG atbx directed at heparin-platelet factor 4 --> excessive thrombin generation in response to sig. reduction in platelets due to heparin
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Heparin-induced osteoporosis; Incidence occurence? (2 parts to answer) | Heparin binds to osteoblasts;
rare; only occurs w/ infusions >6
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Adverse effects of UFH; how to tx? | Bleeding & HIT & heparin-induced osteoporosis
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How to tx UFH-induced bleeding? | Tx with IV bolus of protamine sulfate (1 mg neutralizes 100 units of UFH)
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Bivalirudin; What is it for? | Direct thrombin inhibitor;
Used to tx HIT
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What is used to tx HIT? | Argatroban, Bivalirudin, & Fondaparinux
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___% of LMWH molecules inactivate thrombin? | 25-50%
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Compare UFH's and LMWH's molecular weight | LMWH is 1/3 the molecular weight of UFH
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UFH VTE tx dosing | 80 mg IV bolus + 18mg/kg IV continuous infusion
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UFH VTE prophylaxis dosing | 5000 Units SC q8h
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LMWH (enoxaparin) VTE tx dosing | 1 mg/kg SC q12h OR 1.5 mg/kg q24h;
renal adjustment: 1 mg/kg SC q24h (CrCl<30mL/min)
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Created by:
dangitjitsu
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