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Cardio - VTE

DVT + PE

Argatroban; What is it for? Direct thrombin inhibitor; Used to tx HIT
HIT How is it formed? Heparin-Induced Thrombocytopenia Immune-mediated rxn--> IgG atbx directed at heparin-platelet factor 4 --> excessive thrombin generation in response to sig. reduction in platelets due to heparin
Heparin-induced osteoporosis; Incidence occurence? (2 parts to answer) Heparin binds to osteoblasts; rare; only occurs w/ infusions >6
Adverse effects of UFH; how to tx? Bleeding & HIT & heparin-induced osteoporosis
How to tx UFH-induced bleeding? Tx with IV bolus of protamine sulfate (1 mg neutralizes 100 units of UFH)
Bivalirudin; What is it for? Direct thrombin inhibitor; Used to tx HIT
What is used to tx HIT? Argatroban, Bivalirudin, & Fondaparinux
___% of LMWH molecules inactivate thrombin? 25-50%
Compare UFH's and LMWH's molecular weight LMWH is 1/3 the molecular weight of UFH
UFH VTE tx dosing 80 mg IV bolus + 18mg/kg IV continuous infusion
UFH VTE prophylaxis dosing 5000 Units SC q8h
LMWH (enoxaparin) VTE tx dosing 1 mg/kg SC q12h OR 1.5 mg/kg q24h; renal adjustment: 1 mg/kg SC q24h (CrCl<30mL/min)
Created by: dangitjitsu