Rang and dale H5
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| acetylcholine (muscarine) | ° quaternaire ammoniumverbinding
° neurotransmitter:
effect: - muscarine: ~effecten thv PS
zenuwuiteinden
- stimuleert zweetsecretie (OS)
- VD (indirect-> NO)
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| carbachol | carbamylgroep
° zelfde potentie als Ach voor nicotine- en muscarine R, mr bestendig tegen hydrolyse door AChE of andere esterasen
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| pilocarpine | ° natuurlijk voorkomende partiële mAChR agonist
° Tertiair amine
° Enige muscarine agonist die nog gebruikt wordt
° Geringe activiteit in hart en GIS
° Voor behandeling glaucoom
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| Atropine | ° Centraal en perifeer actief
° Tertiaire N
° Muscarine R antagonist
° Competitieve antagonist alle mACh R
° Tertiair ammoniumverb: dringt snel in CZS
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| hyoscine | ° Competitieve antagonist alle mACh R
° Tertiair ammoniumverb: dringt snel in CZS
° Tegen wagenziekte
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| ipratropium-bromide | ° Perifeer actief
° Muscarine R antagonist
° Quaternair ammoniumverb: slechte resorptie
° Lokale toediening dmv inhalatie bij astma om bronchospasmen tegen te gaan
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| Suxamethonium | nAchR agonist, depolarisatieblok
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| Pancuronium | ° Perifeer actief
° Nicotine R antagonist
° Quaternair ammoniumverb: slechte resorptie, snelle excretie en niet door BHB en placenta
° Competitieve antagonist van nACh R thv motorische eindplaat
° spierverlamming, transmissieblok
° neostigmine ertege
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| Neostigmine | AchE, BuChE
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| acetylcholine (nicotine) | ° quaternaire ammoniumverbinding
° neurotransmitter:
-nicotine-achtige effecten: thv
* ganglionaire synapsen OS+PS
* MEP (dwarsgestreepte spier)
* synapsen splan
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