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farmaco H5

Rang and dale H5

acetylcholine (muscarine) ° quaternaire ammoniumverbinding ° neurotransmitter: effect: - muscarine: ~effecten thv PS zenuwuiteinden - stimuleert zweetsecretie (OS) - VD (indirect-> NO)
carbachol carbamylgroep ° zelfde potentie als Ach voor nicotine- en muscarine R, mr bestendig tegen hydrolyse door AChE of andere esterasen
pilocarpine ° natuurlijk voorkomende partiële mAChR agonist ° Tertiair amine ° Enige muscarine agonist die nog gebruikt wordt ° Geringe activiteit in hart en GIS ° Voor behandeling glaucoom
Atropine ° Centraal en perifeer actief ° Tertiaire N ° Muscarine R antagonist ° Competitieve antagonist alle mACh R ° Tertiair ammoniumverb: dringt snel in CZS
hyoscine ° Competitieve antagonist alle mACh R ° Tertiair ammoniumverb: dringt snel in CZS ° Tegen wagenziekte
ipratropium-bromide ° Perifeer actief ° Muscarine R antagonist ° Quaternair ammoniumverb: slechte resorptie ° Lokale toediening dmv inhalatie bij astma om bronchospasmen tegen te gaan
Suxamethonium nAchR agonist, depolarisatieblok
Pancuronium ° Perifeer actief ° Nicotine R antagonist ° Quaternair ammoniumverb: slechte resorptie, snelle excretie en niet door BHB en placenta ° Competitieve antagonist van nACh R thv motorische eindplaat ° spierverlamming, transmissieblok ° neostigmine ertege
Neostigmine AchE, BuChE
acetylcholine (nicotine) ° quaternaire ammoniumverbinding ° neurotransmitter: -nicotine-achtige effecten: thv * ganglionaire synapsen OS+PS * MEP (dwarsgestreepte spier) * synapsen splan
Created by: 100000194061121



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