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Drug Receptor/Effect

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Target Organ
Drug receptor
Agonist effect
Antagonist effect
Heart rate (sympathetic)   Beta-1 & Beta-2   Increase   Decrease  
Heart rate (cholinergic)   Cholinergic   Decrease   Increase  
Heart (contractibility)   Beta-1 and Beta-2   Increase   Decreaese  
Blood vessels (Arterial-alpha)   Alpha-1   Vasoconstriction   ------  
Blood vessels (Arterial -beta)   Beta-2   Vasodilation   ------  
Lungs (bronchioles-sympathetic)   Beta-2   Bronchodilation   Bronchoconstriction  
Lungs (bronchioles-cholinergic)   Cholinergic   Bronchoconstriction   Bronchodilation  
Lungs (Airway secretions)   Cholinergic   Increase   Decrease  
Eye (Pupils-sympathetic)   Alpha-1   Mydriasis   Miosis  
Eye (Pupils-cholinergic)   Cholinergic   Miosis   Mydriasis  
Lens of Eye (Accommodation)   Cholinergic   ------   Decrease (blurred vision)  
Eye (Lacrimation)   Cholinergic   ------   Decrease (dry eyes)  
Mouth (Salivation)   Cholinergic   ------   Decrease (dry mouth)  
Stomach (Acid secretion)   Cholinergic   Increase   Decrease  
GI Tract (Motility)   Cholinergic   Increase   Decrease  
Bladder Wall (Detrusor Muscle)   Cholinergic   Contraction (enhance urination)   Relaxation (inhibit urination)  
Bladder Sphincter (Sympathetic)   Alpha-1   Constriction (inhibit urination)   Relaxation (enhance urination)  
Bladder Sphincter (Cholinergic)   Cholinergic   Relaxation (enhance urination)   Contraction (inhibit urination)  
Uterus (labor contractions)   Beta-2   Decrease (Inhibit labor)   ------  
Skin (Sweat)   Cholinergic   Increase   Decrease  


   


 
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Created by: tlaugherty