Cancer Drugs and their specific mechanisms of action
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Alkylating Agents | Damages DNA
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| Antimetabolites | Interferes with DNA synthesis by mimicking metabolites needed for cancer cell reproduction
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| Antitumor antibiotics | Modifies DNA function and RNA transcription
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| Plant alkaloids | Inhibits cellular replication during metaphase of mitosis
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| Nitrosoureas | Blocks specific enzymes needed for replication
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| Corticosteroids | Disrupts cell membrane, inhibits protein synthesis, depresses immune system
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| Hormones- Cell Cycle Nonspecific | Stimulates cellular differentiation, decreases proliferation
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| Hormones- Aromatase Inhibitors | Inhibits an enzyme needed for estrogen synthesis
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| Hormones- Selective Estrogen Receptor Modulator (SERM) | Estrogen antagonist
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| Dexamethasone | Decrease inflammation and immune response (especially with Taxol) and increases appetite
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| Emend | Blocks neurokinin, the substance in the brain causing nausea & vomiting. Lasts 1 week
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| Chlorpromazine | Decreases shivering response to chemo (shivering uses energy)
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| Ativan | Relaxation, decreases CINV
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| Benadryl | Blocks histamine response to decrease allergic reaction; always given with Taxol
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