Pharm3 test1
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| Penicillin G | works for gram positive rods.
Give with aminoglycosides for enterococcus
Treat syphilis, anthrax, and actinomycetes israelii
Staph is resistant
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| Penicillin V | Better oral absorption
stable in acidic conditions
Less active, only used for minor infections
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| Penicillin procaine, benzathine | suppository forms
Im forms
long acting
procaine and benzathine are anesthetics
prophylaxis for rheumatic fever during step
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| Methicillin | Penicillinase resistant,
used for staph
interstitial nephritis-not used in us anymore
MRSA
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| Nafcillin | Penicillinase resistant
used for staph
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| Oxavillin | Penicillinase resistant
used for staph
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| Ampicillin | Semisythetics, more gram negative action
combined with beta lactmase inhibitors (clavulanate)
Expanded action for HELPSS ME
effects oral contraceptives
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| Amoxicillin | Semisythetics, more gram negative action
combined with beta lactmase inhibitors (clavulanate)
which expands scope
Expanded action for HELPSS ME
less diarrhea
effects oral contraceptives
Used for otitis media and sinusitis, UTIS,animal bites
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| Ticarcillin | antipseudomonal penicillins
Given with beta lactamase inhibitors
treats gram negative aerobic and mixed
Given with aminoglycosides sometimes
Excess sodium can be bad for CHF
prolongs bleeding time
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| Piperacillin | Ureidopenicillin
Broadest penicillin
treats community acquired pneumonia,
for non-socimial pneumonia, combine with aminoglycoside in case Ps. aeruginosa is present. Use higher doses.
Used for UTIs and e coli stuff
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| Aztreonam | "Monobactam"
Highly resistant to enzymatic inactivation from gram negative
only active against gram negative rods
No allergies.
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| Imipenem | Given with Cilastatin to prevent metabolism by the kidneys.
Resistant to most beta lactamases, but not metallo- ones
Extremely broad spectrum, powerful, used for serious hospital acquired infections
use with aminoglycosides for Ps aeruginosa
seizures
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| Meningitis | the 3rd generation cephalosporins, Ceftriaxone, Ceftizoxime, and Ceftazidime, work. NOT IF LISTERIA
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| Cefazolin | 1st generation Drug of choice for surgical prophylaxis
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| First generation Cephalosporins | good for gram positive, modest gram negative.
works for Proteus, Ecoli, Klebsiella.
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| Second generation | Less positive, more negative
Haemophilus, moraxella. Not for pseudomonas, creates mutants.
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| Cefuroxime | Second generation, Treats strep
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| Third generation | Much more active against gram negative, good for resistant ones. Causes enterobacter mutants.
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| Ceftazidime | third generation, works against pseudomonas aeroginosa. meningitis.
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| Gonorrhea | third generation, cefixime and ceftriaxone are used
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| Ceftriaxone | Meningitis and neurological problems from lymes disease borrelia
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| Cefepime | Fourth generation. Resistant to deactivation by chromosomal beta lactimases.
used for: pseudomonas, enterobacter (UTI), and penicillin resistant Strep. And Meningitis
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| Ceftaroline | fifth generation. Community acquired pneumonia, acute staph skin infection
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| Chloramphenicol | Life threatening meningitis and ricketts. Used when allergies present.
Possible bone marrow toxicity, aplastic anemia. Gray baby syndrome in very young babies.
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| Tetracyclines | Cause esophagus problems and teeth problems. Take standing up with 100ml of water. BINDS CALCIUM DO NOT DO THIS OR YOUR BONES WILL DIE.
TetAE pumps them out. TetM only tetracycline
not for gram positive
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| Doxycycline | Doesnt cause renal toxicity.
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| More Tetracyclines | Gastric ulcers, chlamydia, mycoplasma pneumonia, tick diseases, periodonitis. Can cause superinfections. Demelocycycline-sun sensitivity and vasopresson inhibitions
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| Tigecycline | IV and doesnt interfere with kidneys. Not affected by Tet resistance shit. Used for skin infections, and intra-abdominal infections
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| Macrolides | Binds 50s. Antagonistic with chloremphanicol. Inhibit P450 enzymes except azithromycin
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| Erythromycin | Mycoplasma pneumonia, legionella pneumophila, First line for chlamydial infections in pregnant women. Used in penicillin allergies for gram positive coccus, preventing endocarditis in dental procedures and prophylaxis for rheumatic fever. Liver toxicity.
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| Clarithromycin | is more active against mycobacterium in AIDS and Haemophyllus
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| Azithromycin | better po absortption, 5 days of therapy, not for sepsis, 3 day half life. One dose for chlamydia, most active against haemophylous, less against staph and strep. DOES NOT INTERFERE WITH p450
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amarche1
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