Aerosol Medication Definitions
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| Aerosol | suspension of solid or liquid particles in gas
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| Goals of aerosol | *drugs delivered directly to site of action
* Therapeutic action with minimal side effects
* Greater efficacy and safety
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| MDI | Metered dose inhaler
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| DPI | Dry powder inhaler
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| SVN | Small volume nebulizer
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| USN | ultrasonic nebulizer
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| hand-bulb atomizer | nose spray
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| vibrating mesh nebulizer | like the USN ultrasonic nebulizer
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| Jet Nebulizer | gas powered directed through a restricted orifice (the jet) - incorporates baffles to decrease the number of large aerosol particles
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| Peak flow | a small, hand held device used to monitor a person's ability to breath OUT
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| Spacer | simple valueless extension
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| Chamber | incorporates a valve resulting in higher resirable drug dosage (will have musical note if you breath to fast)
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| LVN | Large volume nebulizer
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| SPAG | Small particle aerosol generator
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| instability | tendancy for particles to be removed from suspension
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| penetration | refers to the maximum depth that suspended particles can be carried into the pulmonary tree by inhaled tidal air
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| deposition | result of an aerosol's eventual instability; particles "fall out" on a nearby surface
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| Retention | proportion of particles deposited within the respiratory tract
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| clearance | removal, the fact that some particles are exhaled
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| coalescene | two particles form one larger particle
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| nebulizer | a device that generates aerosol of uniform size
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| gravity | large particles are deposited before smaller particles
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| physical nature of particle | some particles absorb water, become large and rain-out, while others evaporate, become smaller and are conducted further into respiratory tree.
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| Hygroscopic | particles tend to absorb water from the resp tract, and become larger and rain out
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| Hypertonic | particles add water, increase size, and decrease deposition to smaller airways
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| hypotonic | particles lose water and increase deposition to small airways
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| isotonic | solutions will remain fairly stable in size until they are deposited
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| For maximal deposition | slow deep breath, inhale through an open mouth, end inspiration, pause, follow with a slow, complete exhaustion
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