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Resp 15
Aerosol Medication Definitions
| Question | Answer |
|---|---|
| Aerosol | suspension of solid or liquid particles in gas |
| Goals of aerosol | *drugs delivered directly to site of action * Therapeutic action with minimal side effects * Greater efficacy and safety |
| MDI | Metered dose inhaler |
| DPI | Dry powder inhaler |
| SVN | Small volume nebulizer |
| USN | ultrasonic nebulizer |
| hand-bulb atomizer | nose spray |
| vibrating mesh nebulizer | like the USN ultrasonic nebulizer |
| Jet Nebulizer | gas powered directed through a restricted orifice (the jet) - incorporates baffles to decrease the number of large aerosol particles |
| Peak flow | a small, hand held device used to monitor a person's ability to breath OUT |
| Spacer | simple valueless extension |
| Chamber | incorporates a valve resulting in higher resirable drug dosage (will have musical note if you breath to fast) |
| LVN | Large volume nebulizer |
| SPAG | Small particle aerosol generator |
| instability | tendancy for particles to be removed from suspension |
| penetration | refers to the maximum depth that suspended particles can be carried into the pulmonary tree by inhaled tidal air |
| deposition | result of an aerosol's eventual instability; particles "fall out" on a nearby surface |
| Retention | proportion of particles deposited within the respiratory tract |
| clearance | removal, the fact that some particles are exhaled |
| coalescene | two particles form one larger particle |
| nebulizer | a device that generates aerosol of uniform size |
| gravity | large particles are deposited before smaller particles |
| physical nature of particle | some particles absorb water, become large and rain-out, while others evaporate, become smaller and are conducted further into respiratory tree. |
| Hygroscopic | particles tend to absorb water from the resp tract, and become larger and rain out |
| Hypertonic | particles add water, increase size, and decrease deposition to smaller airways |
| hypotonic | particles lose water and increase deposition to small airways |
| isotonic | solutions will remain fairly stable in size until they are deposited |
| For maximal deposition | slow deep breath, inhale through an open mouth, end inspiration, pause, follow with a slow, complete exhaustion |