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ARDS/ARF definition | Pathologic acute injury to the lung (direct or indirect). Inflammatory syndrome marked by disruption of alveolar-capillary membrane
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Mortality rate of ARDS | Very deadly, 50%
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What are the symptoms of ARDS? | Decreased lung compliance
-Resulting in falling PO2 despite increase FiO2*******
Decreased surfactant
-Resulting in atelectasis
Increase in # of neutrophils and macrophages (“Phil and Mac attack”)
-Resulting in PROTEIN-RICH pulmonary edema
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What are the causes of ARDS/ALI? | Direct Lung Injury: IN the lung
--aspiration, trauma, pneumonia
Indirect Lung injury: from the blood
--Sepsis, cardiopulmonary bypass, pancreatitis, transfusions
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What is capnometry? | Measuring the amount of CO2 within/given off by the patient
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PETCO2 | partial pressure of end tidal CO2. i) Measured by the ventilator and is 1-5mm < PaC02 in the STABLE patient.
ii) An extremely abnormal value indicates CO2 retention and could be an ominous sign of a change in condition. However……
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Permissive hypercapnia | Maintaining lower tidal volumes to cause a rise in PaCO2 keeping pH above 7.25. This helps to prevent Barotrauma/Volutrauma. Keep in mind this is risky business, CO2 very strong vasodilator.GOAL: Maintain PaCO2 less than or equal to 60 mmHg and peak airw
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What position should patient be in for when caring ALI/ARDS? | a) PRONE POSITIONING
i) Strongly supported by EBP
ii) Shifts edema and recruits aveoli
iii) Change in position= Improved oxygenation!
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Supportive care for ARDS means | you treat UNDERLYING CONDITION
i) Interrupt inflammatory cascade
(1) Monitor Protein C as it is a marker for SYSTEMIC INFLAMMATION.
ii) Decrease Oxygen demand and promote sleep and rest
(1) Cluster your care to allow maximal rest for the patient
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Make sure that ARDS patient has : | Maintain SaO2 >90% using LOWEST FiO2 (decreased chance of O2 toxicity),Head of bed > 30 degrees,GOOD ORAL CARE TO PREVENT PNEUMONIA,Mobility, ROM, Q2 Turns
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Medications typically used with ARDS patients | i) Inhaled Nitric Oxide (Pulmonary vasodilation),Steroids (still controversial),Anti-inflammatory agents
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Confusion/restlessness are early signs of | CO2 retention
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Pa02/ Fi02 ratio | 80 / 20% (room air) = 400
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Hypoxemia is ---- oxygen therapy | refractory
"A falling P02 in the face of a rising Fi02"
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BOOP | Bronchiolitis Obliterans Organizing Pneumonia
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CARS | Compensatory Anti-inflammatory Response Syndrome (more susceptible to infection)
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COP | Cryptogenic Organizing Pneumonitis
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DAD | Diffuse Alveolar Damage
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Type I alveolar epithelial cells | 90% total alveolar surface within lungs
Highly susceptible to injury inflammation
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Type II alveolar epithelial cells | Produce, store, secrete pulmonary surfactant
10% total alveolar surface within lungs
disruption of synthesis/storage of surfactant collapse of alveoli, impairment of pulmonary gas exchange, development of fibrosis and loss of compliance “stiff lungs”
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In 2002 Severe Acute Respiratory Syndrome, or SARS killed | 15% of those infected
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Of the H1N1 influenza A (swine flu) 2009/2010 18,000 deaths | 14 – 46% mortality rate primarily from ARDS
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