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Question
Answer
ARDS/ARF definition   Pathologic acute injury to the lung (direct or indirect). Inflammatory syndrome marked by disruption of alveolar-capillary membrane  
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Mortality rate of ARDS   Very deadly, 50%  
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What are the symptoms of ARDS?   Decreased lung compliance -Resulting in falling PO2 despite increase FiO2******* Decreased surfactant -Resulting in atelectasis Increase in # of neutrophils and macrophages (“Phil and Mac attack”) -Resulting in PROTEIN-RICH pulmonary edema  
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What are the causes of ARDS/ALI?   Direct Lung Injury: IN the lung --aspiration, trauma, pneumonia Indirect Lung injury: from the blood --Sepsis, cardiopulmonary bypass, pancreatitis, transfusions  
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What is capnometry?   Measuring the amount of CO2 within/given off by the patient  
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PETCO2   partial pressure of end tidal CO2. i) Measured by the ventilator and is 1-5mm < PaC02 in the STABLE patient. ii) An extremely abnormal value indicates CO2 retention and could be an ominous sign of a change in condition. However……  
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Permissive hypercapnia   Maintaining lower tidal volumes to cause a rise in PaCO2 keeping pH above 7.25. This helps to prevent Barotrauma/Volutrauma. Keep in mind this is risky business, CO2 very strong vasodilator.GOAL: Maintain PaCO2 less than or equal to 60 mmHg and peak airw  
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What position should patient be in for when caring ALI/ARDS?   a) PRONE POSITIONING i) Strongly supported by EBP ii) Shifts edema and recruits aveoli iii) Change in position= Improved oxygenation!  
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Supportive care for ARDS means   you treat UNDERLYING CONDITION i) Interrupt inflammatory cascade (1) Monitor Protein C as it is a marker for SYSTEMIC INFLAMMATION. ii) Decrease Oxygen demand and promote sleep and rest (1) Cluster your care to allow maximal rest for the patient  
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Make sure that ARDS patient has :   Maintain SaO2 >90% using LOWEST FiO2 (decreased chance of O2 toxicity),Head of bed > 30 degrees,GOOD ORAL CARE TO PREVENT PNEUMONIA,Mobility, ROM, Q2 Turns  
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Medications typically used with ARDS patients   i) Inhaled Nitric Oxide (Pulmonary vasodilation),Steroids (still controversial),Anti-inflammatory agents  
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Confusion/restlessness are early signs of   CO2 retention  
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Pa02/ Fi02 ratio   80 / 20% (room air) = 400  
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Hypoxemia is ---- oxygen therapy   refractory "A falling P02 in the face of a rising Fi02"  
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BOOP   Bronchiolitis Obliterans Organizing Pneumonia  
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CARS   Compensatory Anti-inflammatory Response Syndrome (more susceptible to infection)  
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COP   Cryptogenic Organizing Pneumonitis  
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DAD   Diffuse Alveolar Damage  
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Type I alveolar epithelial cells   90% total alveolar surface within lungs Highly susceptible to injury  inflammation  
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Type II alveolar epithelial cells   Produce, store, secrete pulmonary surfactant 10% total alveolar surface within lungs disruption of synthesis/storage of surfactant  collapse of alveoli, impairment of pulmonary gas exchange, development of fibrosis and loss of compliance “stiff lungs”  
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In 2002 Severe Acute Respiratory Syndrome, or SARS killed   15% of those infected  
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Of the H1N1 influenza A (swine flu) 2009/2010 18,000 deaths   14 – 46% mortality rate primarily from ARDS  
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